Romatoid Artrit Hastalarında Hastalık Aktivitesi ile Alerjik Hastalık Sıklığı İlişkisinin Değerlendirilmesi

Öz

Amaç: Bu çalışmada Romatoloji Polikliniğine başvuran RA’lı hastalarda alerjik hastalıkların sıklığı ve hastalık aktivitesi ile olan ilişkisinin değerlendirilmesi etween

Materyal ve Metot: Hastalara, sosyodemografik veri formu ve “Avrupa Topluluğu Solunum Sağlığı Çalışması” (European Community Respiratory Health Study, ATSSÇ) anketi uygulanarak alerjik hastalıkların yaygınlığı ile RA hastalık aktivitesi (DAS-28) arasındaki ilişki saptanmaya çalışılmıştır

Bulgular: Toplam 135 hasta çalışmaya alındı (108 kadın 27 erkek; yaş ortalaması 53,0±11,1 yıldı). Kadınların %33,3’ünde astım benzeri bulgular görülmüştür. Erkeklerin %33,3’ünde astım benzeri bulgular ve %33,3’ünde non enfeksiyöz rinit görülmektedir. DAS-28 skoru ile anket tanılarının sıklığı arasında istatistiksel olarak anlamlı bir fark bulunamamıştır( p=0,75).

Sonuç: Çalışmamızda RA aktivite skoru ile ATSSÇ tanıları arasında anlamlı bir ilişki bulunmadı. Literatür taramamızda; RA hastalarında DAS-28 ile alerjik hastalık ilişkisini araştıran bir çalışma bulamadık. Bu nedenle bu sonucun önemli olduğu kanaatindeyiz.

Anahtar Kelimeler

• Alerjik hastalıklar,romatoid artrit,anket

Evaluation of the Relationship Between Disease Activity and Allergic Disease Prevalence in Patients with Rheumatoid Arthritis

Abstract

Objectives: We aimed to assess the relationship between disease activity and frequency of allergic diseases in patients with rheumatoid arthritis who were admitted to a rheumatology outpatient clinic.

Materials and methods: Socio-demographic data form and the European Community Respiratory Health Study (ECRHS) questionnaire were applied to the patients and the prevalence of allergic patients by applying ECHRS and the relationship between RA disease activity was assessed.

Results: A total of 135 patients were included in the study (108 female and 27 male); average age 53,0 ± 11,1 years. Asthma-like symptoms were observed in 33,33% of women. Asthma-like symptoms in 33,33% of men and 33,33% are non-infectious rhinitis. A statistically significant difference was not found between DAS-28 scores and frequencies of the survey diagnoses (p = 0,75).

Conclusion: We could not find a significant correlation between the diagnosis of RA activity score and ECHRS diagnoses in our study. We could not find a study which focused on  the relationship between allergic diseases and DAS-28 in RA in the literature. Thus, we believe that these results are noteworthy

Keywords

• Allergic diseases,rhematoid arthritis,survey

References

1. Symmons D.P. Looking back: Rheumatoid Arthritis -Etiology, Occurrence and Mortality. Rheumatology 2005;44:14-7.
2. Gabbay E, Tarala R, Will R, Carroll G et al. Interstitial lung disease in recent onset rheumatoid arthritis. Am J Respir Crit Care Med 1997;156:528–35.
3. Hamblin MJ, Horton MR. Rheumatoid arthritis-associated interstitial lung disease: diagnostic dilemma. Pulm Med 2011;2011:872120.
4. Costa DJ, Bousquet PJ, Ryan D et al. Guidelines for allergic rhinitis need to be used in primary care. Prim Care Respir J 2009;18(4):250-7.
5. Konno S, Hizawa N, Fukutomi Y, Taniguchi M, Kawagishi Y, Okada C et al.The prevalence of rhinitis and its association with smoking and obesity in a nationwide survey of Japanese adults. Allergy 2012;67(5):653-60.
6. Pawankar R, Bunnag C, Khaltaev N, Bousquet J. Allergic Rhinitis and Its Impact on Asthma in Asia Pacific and the ARIA Update 2008. World Allergy Organ J. 2012;5(Suppl 3):S212-7.
7. Hajdarbegovic E, Thio B, Nijsten T. Lower lifetime prevalence of atopy in rheumatoid arthritis. Rheumatol Int 2014;34:847-8.
8. Kero J, Gissler M, Hemminki E, Isolauri E. Could Th1 and Th2 diseases coexist? Evaluation of asthma incidence in children with celiac disease, type 1 diabetes, or rheumatoid arthritis: A register study. J Allergy Clin Immunol 2001;108:781–3.

9. de Marco R, Zanolin ME, Accordini S, et al. A new questionnaire for the repeat of the first stage of the European Community Respiratory Health Survey: a pilot study. Eur Respir J 1999;14(5):1044-8.
10. Fransen J, van Riel PL. The Disease Activity Score and the EULAR response criteria. Clin Exp Rheumatol 2005;23(5 Suppl 39):S93-9.
11. Bilge U, Keskin A.Upper respiratory system infection frequency is affected by allergic symptoms and cigarette smoking. Health MED 2013:7;1126-30.
12. Rudwaleit M, Andermann B, Alten R et al. Atopic disorders in ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis 2002;61(11):968-74.
13. Bom AT, Pinto AM. Allergic respiratory diseases in the elderly. Respir Med 2009;103(11):1614-22.
14. Young A, Koduri G, Batley M et al. Mortality in rheumatoid arthritis. increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis. Rheumatology (Oxford) 2007;46(2):350-7.