Polikistik Over Sendromu Olan Kadınlarda Artan Lökosit Sayısının Hyperandrojenizm ve Vücut Kitle İndeksi ile İlişkisi

Öz

Amaç: Bu çalışmanın amacı, polikistik over sendromlu (PKOS) hastalarla kontrol grubunun lökosit (WBC) sayılarını karşılaştırmak ve lökosit sayısı ile metabolik belirteçler ve hormonal değerler arasındaki ilişkiyi değerlendirmektir.

Materyal ve Metot: Çalışma retrospektif olarak yapıldı. Yüz otuz polikistik over sendromlu ve düzenli adet gören 71 sağlıklı kadın çalışmaya alındı. Genel özellikleri ve antropometrik ölçümleri analiz edildi. Tüm katılımcıların hormonal, metabolik ve inflamatuar parametreleri adet döngüsünün foliküler fazında çalışıldı.

Bulgular: PCOS ve kontrol grubunun yaş ortalaması ve vücut kitle indeksi (VKİ) benzerdi (sırasıyla, P = 0.071 ve P = 0.063). Inflamatuar belirteçler, WBC [6.00 (4.51-7.17) karşı 7.20 (5.91-8.41); (P <0.001)] ve c-reaktif protein (CRP) [3.45 (3.30-3.61) karşı 3.48 (3.45-4.98); (P = 0.031)] PKOS grubunda anlamlı olarak yüksek bulundu. WBC’nin bağımlı değişken; total testosteron (TT), seks hormon bağlayıcı globulin (SHBG) ve insülin direncinin homeostatik model değerlendirmesinin (HOMA-IR) belirleyici olarak konduğu bir çoklu regresyon analizinde, WBC’yi, karıştırıcı faktörlerin de göz önüne alınmasından sonra TT ve BMI’nin anlamlı olarak belirlediği bulundu (P = 0.006; P = 0.039, sırasıyla).

Sonuç: Kardiyovasküler hastalıklar için bağımsız bir belirleyici olan WBC, PCOS’u olan kadınlarda yüksektir ve bu durum obezite ve hiperandrojenemi ile açıklanabilir.

 

The Association of Leukocyte Increase with Hyperandrogenism and Body Mass Index in Women with Polycystic Ovary Syndrome

Abstract

Objectives: The aim of this study was to compare the white blood cells (WBC) count in patients with polycystic ovary syndrome (PCOS) with the controls and to assess its relationship between metabolic markers and hormonal measures.

Materials and Methods: The study was conducted retrospectively. One hundred-thirty women with PCOS and 71 healthy women with regular menses were included in the study. General characteristics and anthropometric measures were analyzed. Hormonal, metabolic and inflammatory parameters were studied in all subjects at the follicular phase of the menstrual cycle.

Results:  The average age and body mass index (BMI) of PCOS and the control groups were similar (P=0.071 and P=0.063, respectively). Inflammatory markers, WBC [6.00 (4.51-7.17) vs. 7.20 (5.91-8.41);(P<0.001)] and c-reactive protein (CRP) [3.45 (3.30-3.61) vs. 3.48 (3.45-4.98); (P=0.031)] were significantly higher in the PCOS group. In multiple regression analysis in a model when WBC is the dependent variable and total testosterone (TT), sex hormone binding globuline (SHBG), and homeostatic model assessment of insulin resistance (HOMA-IR) were the predictors, WBC was positively associated with TT levels and BMI even after adjustment for confounders (P=0.006; P=0.039, respectively).

Conclusion: WBC is an independent predictor of cardiovascular disease, is elevated in women with PCOS and is explained by both obesity and hyperandrogenemia. 

Keywords

• PCOS,WBC,CRP,Free androgen index

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