The Relation of Perianal Acrochordons are with Insulin Resistance

Abstract

Objectives: Acrochordons are common benign tumors of the skin. Perianal acrochordons are frequently observed in the examination of the anal region. Abnormal lipid and glucose metabolism are suggested to play a role in the development of acrochordons. The association of perianal acrochordons with insulin resistance is unknown. The aim of this study was to investigate the relationship between perianal skin tags and insulin resistance. Materials and Methods: A total of 21 patients with perianal acrochordons and 21 age, gender and body mass index (BMI) matched controls were prospectively enrolled in the study. Serum glucose, total cholesterol, low‐density lipoprotein (LDL) cholesterol, high‐density lipoprotein (HDL) cholesterol and triglyceride (TG) were measured. Insulin resistance was evaluated by homoeostasis model assessment of insulin resistance (HOMA‐IR) method. HOMA‐IR levels above 2.5 were considered as insulin resistance. Results: There were no statistically significant differences between patients with perianal acrochordons and controls in terms of the glucose, total cholesterol, HDL cholesterol, LDL cholesterol and TG. Mean HOMA‐IR was significantly higher in the patient group of perianal acrochordon (P=0.007). The proportion of patients with insulin resistance was significantly higher in patients with perianal acrochordons than controls (p=0.022). Conclusion: Although acrochordons are closely related to insulin resistance, there are no studies evaluating perianal acrochordons in the literature. The results of this study showed that perianal acrochordons tags are associated with insulin resistance.

Keywords

• Anal examination,acrochordon,insulin resistance

Perianal Akrokordonların İnsülin Direnci ile İlişkisi

Öz

Amaç: Akrokordonlar derinin sık rastlanılan benign tümörleridir. Anal bölgenin muayenesinde perianal akrokordonlar sıklıkla görülmektedir. Anormal lipid ve glukoz metabolizmasının akrokordon gelişiminde rol oynayabileceğini öne sürülmektedir. Perianal akrokordonların insülin direnci ile ilişkisi bilinmemektedir. Bu çalışmanın amacı perianal akrokordon ve insülin direnci arasındaki ilişkiyi araştırmaktır. Materyal ve Metot: Çalışmaya perianal akrokordon saptanan 21 olgu ve yaş, cinsiyet ve vücut kitle indeksi (VKİ) benzer 21 kontrolü dahil edildi. Olguların serum açlık glukoz, total kolesterol, düşük‐ dansiteli lipoprotein (LDL) kolesterol, yüksek‐dansiteli lipoprotein (HDL) kolesterol ve trigliserid (TG) düzeyleri ölçüldü.  İnsülin direnci, homeostasis model insülin rezistans ölçüm modeli (HOMA‐IR) metodu ile hesaplandı. HOMA‐IR düzeyi 2,5 üzerinde olması insülin direnci olarak kabul edildi.    Bulgular: Perianal akrokordon saptananlar ve kontrolleri arasında total kolesterol, HDL kolesterol, LDL kolesterol ve TG düzeyleri açısından istatiksel olarak anlamlı farklılık saptanmadı. Perianal akrokordon hasta grubunda ortalama HOMA‐IR anlamlı yüksek bulundu (p=0,007). İnsülin direnci olan hastaların oranı, perianal akrokordonlu hastalarda kontrollere göre anlamlı olarak daha yüksekti (p=0,022). Sonuç: Akrokordonların insülin direnci ile yakın ilişkili olduğu belirtilmesine karşın literatürde anal akrokordonların değerlendirildiği çalışma bulunmamaktadır. Çalışma perianal akrokordonların insülin direnci ile ilişkisini göstermektedir.  

Anahtar Kelimeler

• Anal muayene,akrokordon,insulin direnci

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