Acil Serviste Renal Koliği Olan Hastalarda Tiyol/Disülfid Homeostazı Nötrofil Lenfosit ve Platelet Lenfosit Oranı

Öz

Amaç: Bu çalışmanın amacı acil servise renal kolik nedeniyle başvuran hastalarda oksidatif stres

markerlarından olan tiyol/disülfid homeostazı parametreleri ile Nötrofil‐Lenfosit ve Platelet‐Lenfosit

oranlarının (NLO, PLO) beraber kullanımının tanı açısından yararlı olup olmadığını araştırmaktır.

Materyal ve Metot: Çalışma 15.05.2018 ile 01.10.2018 tarihleri arasında acil servise başvuran ve çalışmaya

alınan 75 hasta ve kontrol grubu olarak belirlenen 47 sağlıklı kişi ile prospektif olarak yapıldı. Erel ve

Neşelioğlu tarafından yeni geliştirilen bir metot ile oksidatif stres belirteci olan tiyol/disülfid homeostaz

parametreleri ( Tiyol, disülfid, disülfid / native tiyol, disüfid / total tiyol, native tiyol / total tiyol) ile NLO

ve PLO hasta ve kontrol grubunda çalışıldı. Üriner taş hastalığı olan ve olmayanlar arasında bu

parametreler karşılaştırıldı.

Bulgular: Renal koliği olanlarda kontrol grubuna göre, NLO, PLO, disülfid, disülfid /native tiyol ve

disülfid /total tiyol ortalama değerleri anlamlı derecede yüksek bulunurken (sırasıyla p= 0.010, <0.001,

<0.001, <0.001, 0.023, 0.012), native tiyol ve total tiyol ortalama değerleri anlamlı derecede düşük

bulundu (sırasıyla p=0.018 ve 0.001). Üriner taş hastalığı olan grupta olmayan gruba göre disülfid,

disülfid /native tiyol, NLO ve PLO ortalama değerleri anlamlı derecede yüksek bulundu (sırasıyla p

<0.001, <0.001, <0.001, <0.001).

Sonuç: NLO ve PLO ile tiyol/disülfid homeostaz parametrelerinin renal kolik tanısında beraber

kullanılması bu hastalarda tanının konulması açısından faydalıdır.

Anahtar Kelimeler

• Renal Kolik,oksidatif stres,tiyol/disülfid homeostazı

Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic

Abstract

Objectives: This study's aim is to investigate if using thiol/disulphide homeostasis parameters which are oxidative stress markers together with Neutrophile-Lymphocyte and Platelet-Lymphocyte ratio (NLR, PLR) is diagnostically useful in the patients who present to the emergency department with renal colic.
Materials and Methods: The study was made prospectively with 75 patients who were admitted to the emergency department between 15.05.2018 and 01.10.2018 and 47 healthy subjects who were determined as control group. Thiol/disulphide homeostasis parameters (thiol, disulphide, disulphide / native thiol, disulphide / total thiol, native thiol / total thiol) which are oxidative stress markers are measured by a new method which was developed by Erel and Neşelioğlu in the patient and control groups, also NLR and PLR were studied. These parameters were compared also between the patient groups with urinary stone disease and that without.
Results: NLR, PLR, disulphide, disulphide /native thiol and disulphide /total thiol average values were found significantly high (respectively p= 0.010, <0.001, <0.001, <0.001, 0.023, 0.012), but native thiol and total thiol average values were found significantly low (respectively p=0.018 and 0.001) in the patient group. Disulphide, disulphide /native thiol, NLR and PLR average values were found significantly high (respectively p <0.001, <0.001, <0.001, <0.001) in the patient group.
Conclusion: Using NLR and PLR in renal colic diagnosis together with thiol/disulphide homeostasis parameters is useful for these patients to make a diagnosis.

Keywords

• Renal colic,oxidative stres,thiol/disulphide homeostasis

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