Demir Eksikliği Anemisi Üreme Çağındaki Kadınlarda Bilişsel Fonksiyonlarla İlişkili midir?

Öz

Amaç: Bu çalışmanın amacı, üreme çağındaki kadınlarda demir eksikliği anemisinin bilişsel

fonksiyonlar, fiziksel fonksiyonellik, psikiyatrik morbidite, yorgunluk ve yaşam kalitesi üzerindeki

etkilerini incelemekti.

Materyal ve Metot: Yaşları 18‐50 arasında değişen ve demir eksikliği anemisi olan 33 kadın ve anemisi

olmayan 32 sağlıklı kadın çalışmaya dahil edildi. Laboratuvar analizi, nöropsikolojik testler, Beck

Depresyon Ölçeği, Beck Anksiyete Ölçeği, VAS yorgunluk, Sağlık Değerlendirme Anketi ve Kısa Form‐36

değerlendirildi.

Bulgular: Gruplar arasında demografik özellikler açısından anlamlı fark saptanmadı. Demir eksikliği

Anemisi olan grupta Digit Forward/Backward, Digit Span Total, Sağlık Değerlendirme Anketi, Beck

Depresyon Ölçeği, Beck Anksiyete Ölçeği, Kısa Form‐36 ve yorgunluk skorları kontrol grubuna gore

anlamlı olarak daha düşüktü. Korelasyon analizinde eğitim, serum demir, ferritin ve hemoglobin

düzeyleri ile bilişsel test skorları ve yorgunluk arasında anlamlı ilişkili bulundu. Serum demir, ferritin ve

hemoglobin düzeyleri ile Sağlık Değerlendirme Anketi, Beck Depresyon Ölçeği, Beck Anksiyete Ölçeği

ve Kısa Form‐36 skorları arasında anlamlı ilişki bulundu.

Sonuç: Demir eksikliği anemisi üreme çağındaki kadınlarda bilişsel fonksiyonları, fiziksel

fonksiyonelliği, yaşam kalitesini, yorgunluğu, anksiyete ve depresyon semptomlarını negative yönde

etkilemektedir.

Anahtar Kelimeler

• Demir eksikliği anemisi,üreme çağındaki kadınlar,bilişsel fonksiyonlar

Is Iron Deficiency Anemia Associated with Cognitive Functions in Reproductive-Age Women?

Abstract

Abstract

Objectives: The aim of the study was to determine whether iron deficiency anemia (IDA) in reproductive-age women affects cognitive functioning, physical functioning, psychiatric morbidity, fatigue and quality of life.

Materials and Methods: Thirty-three women aged between 18-50 years with IDA and 32 non-anemic healthy women were included in the study. Laboratory analyses, neuropsychological tests, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), VAS fatigue, Health Assessment Questionnaire (HAQ-DI) and Short Form-36 (SF-36) were assessed.

Results: There was no significant difference in demographic characteristics of the patients between groups. Digit Forward/Backward, Digit Span Total, HAQ-DI, BAI, BDI, SF-36, fatigue scores in IDA group were significantly lower than the controls. Correlation analysis revealed that education, serum iron, ferritin, and hemoglobin levels were associated with cognitive test scores and fatigue. Serum iron, ferritin, and hemoglobin levels were found to be associated with HAQ-DI, BAI, BDI, and SF-36 scores.

Coclusion: IDA negatively affects cognition, physical functioning, quality of life, fatigue, symptoms of anxiety and depression in reproductive-age women. 

Keywords

• Iron deficiency anemia,reproductive-age women,cognition

References

1. 1. Murray-Kolb L.E, Beard JL. Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr 2007;85:778-87.
2. 2. Khedr E, Hamed SA, Elbeih E, El-Shereef H, Ahmad Y, Ahmed S. Iron states and cognitive abilities in young adults: neuropsychological and neurophysiological assessment. Eur Arch Psychiatry Clin Neurosci 2008;258:489-96.
3. 3. Pollitt E. Iron deficiency and cognitive function. Annu Rev Nut 1993;13:521-37.
4. 4. Parmar BJ. Iron deficiency: beyond anemia. Acad J Ped Neonatol 2016;2:1-4.
5. 5. Jauregui-Lobera I. Iron deficiency and cognitive functions. Neuropsychiatr Dis Treat 2014;10:2087-95.
6. 6. Elwood PC, Hughes D. Clinical trial of iron therapy on psychomotor function in anemic women. British Med J 1970;3:254-5.
7. 7. Patterson AJ. Iron deficiency in Australian women: development, implications and treatment. PhD Thesis, 1999, University of Newcastle, NSW.
8. 8. Chellappa AR, Karunanidhi S. Effect of iron and zinc supplementation on cognitive functions of female adolescents in Chennai, India. International Conference on Nutrition and Food Sciences IPCBEE 2012;39:17-24.

9. 9. Noorazar SG, Ranjbar F, Nemati N, Yasamineh N, Kalejahi P. Relationship between severity of depression symptoms and iron deficiency anemia in women with major depressive disorder. Anal Res Clin Med 2015;3:219-24.
10. 10. Patterson A, Brown WJ, Roberts DCK. Dietary and supplement treatment of iron deficiency results in improvements in general health and fatigue in Australian women of childbearing age. J Am Coll Nutr 2001;20:337-42.
11. 11. Greig AJ, Patterson AJ, Collins CE, Chalmers KA. Iron deficiency, cognition, mental health and fatigue in women of childbearing age: a systematic review. J Nutr Sci 2013;2:1-14.
12. 12. Joy S, Kaplan E, Fein D. Speed and memory in the WAIS-III Digit Symbol-coding subtest across the adult lifespan. Arch Clin Neuropsychol 2004;19:759-67. 13. Savaşir I, Şahin N. WISC uyarlamaçalışmalarıönrapor -I. Turk J Psychol 1978;1:33-7.
13. 14. Kucukdeveci AA, Sahin H, Ataman S, Griffiths B, Tennant A. Issues in cross-cultural validity: example from the adaptation, reliability, and validity testing of a Turkish version of the Stanford Health Assessment Questionnaire. Arth Rheum 2004;51:14-9.
14. 15. Pinar R. Reliability and construct validity of the SF-36 in Turkish cancer patients. Qual Life Res 2005;14:259-64.
15. 16. Hisli N. Beck Depression Inventory for university students on the validity and reliability. Psikoloji Dergisi 1989;7:3-13.
16. 17. Ulusoy M, Sahin NH, Erkmen H. Turkish version of the Beck Anxiety Inventory: psychometric properties. J Cogn Psychother 1998;12:163-72.
17. 18. Feise RJ, Menke JM. Functional Rating Index: a new valid and reliable instrument to measure the magnitude of clinical change in spinal conditions. Spine 2001;26:78-87.
18. 19. Moos T, Rosengren Nielsen T, Skjorringe T, Morgan EH. Iron trafficking inside the brain. J Neurochem 2007;103:1730–40.
19. 20. Ukkirapandian K, Natarajan N, Prassanaraghavan K, Mohan P, Selvam L. A clinical study on effects of iron deficiency anemia on cognitive function among undergraduate paramedical students. Int J Med Sci Public Health 2014;3:948-50.
20. 21. Fordy J, Benton D. Does low iron status influence psychological functioning? J Hum Nutr Diet 1994;7:127-33.
21. 22. Petranovic D, Batinac T, Petranovic D, Ruzic A, Ruzic T. Iron deficiency anemia influences cognitive functions. Med Hypotheses 2008;70:70-2.
22. 23. Sareen M, Sareen S, Khajuria S, Roy S. Impact of iron levels on cognitive functioning among dental students of Udaipur, Rajasthan (India). F1000 Research 2012;1:54.
23. 24. Semiz M, Uslu A, Korkmaz S et al. Assessment of subjective sleep quality in iron deficiency anemia. Afr Health Sci 2015;15:621-7.
24. 25. Patterson AJ, Brown WJ, Powers JR, Roberts DCK. Iron deficiency, general health and fatigue: results from the Australian Longitudinal Study on Women’s Health. Qual Life Res 2000;9:491-7.
25. 26. Stugiewicz M, Tkaczyszyn M, Kasztura M, Banasiak W, Ponikowski P, Jankowska EA. The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications. Eur J Heart Fail 2016;18:762-73.
26. 27. Rangan AM, Blight GD, Binns CW. Iron Status and Non-Specific Symptoms of Female Students. J Am Coll Nutr 1998;17:351-5.