Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis

Fadime Kılınç; Ayşe Akbaş

doi:10.17098/amj.409044

Research Article

Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis

Year 2018, Volume: 18 Issue: 1, 52 - 60, 30.03.2018

Fadime Kılınç Ayşe Akbaş

https://doi.org/10.17098/amj.409044

Abstract

Objectives: Hand, foot and mouth disease
is a viral infection which is characterized by fever, vesicular lesions in
palm, sole, and mouth, and is frequent observed in children. We aimed to
investigate the clinical characteristics of 33 patients admitted to the Clinic
of Dermatology in Ankara Atatürk Training and Research Hospital between 2015
and 2017.
Materials and Methods: Thirty-three patients were evaluated for the
presence of symptoms such as fever, pain, burning, pruritus, age, sex,
localization of lesions, family and atopy history.
Results: The median age of the 33 patients studied was 12.21±9.45 years
(min-max: 1-36), there were 23 children and 10 adults. The mean duration of
illness was calculated as 3,9±1,9 days (min-max: 1-7). 36.36% of the patients
(n = 12) were male. 26 (78.78%) patients had fever history. There were atopy
histories in 5 patients (15.15%), and medical history in the family and close
encountered persons of 9 patients (27.27%). Eight patients (24.24%) complained
of sore throat, 7 patients (21.21%) of itching. Vesicular lesions were
monitored in the palms and soles of 31 patients (93.93%) and in the mouths of
24 patients (72.72%). The most frequent involvement site was hand plam
(96.96%). Only 2 patients (6.06%) developed onychomadesis after the disease.
Conclusion: We have observed a female gender dominance unlike other
studies. It should not be forgotten that; although more common in children the
disease can be observed also in young adults, it can involve body parts other
than hand-foot-mouth, and long follow ups are important in the severe form of
the disease.

Keywords

Hand foot and mouth disease, infection, viral

References

1. Uğraş M, Küçük Ö, Biçer S ve ark. İki yıllık periyot içinde el-ayak-ağız hastalığı olan çocukların değerlendirilmesi. J Kartal TR 2014;25:34-8.
2. Liu B, Luo L, Yan Set al. Clinical Features for Mild Hand, Foot and Mouth Disease in China. PLoS ONE 2015;10(8):e0135503.
3.Mehta KIS, Mahajan VK. Hand, Foot and Mouth Disease. Indian pediatrics 2010;47:345-6. 4. Chen SM, LiQiu, Du ZH et al. Spatial Clustering of Severe Hand-Foot-Mouth Disease Cases in Hainan Island, China. Japanese Journal of Infectious Diseases 2017;70(6):604-8.
5.Öncel EK, Nar I, Özsürekçi Y et al. Demographic and Clinical Findings in Children with Enteroviral Infection Outbreak. J Pediatr Inf 2013;7:97-101.
6.Zhuang ZC, Kou ZQ, Bai YJ et al. Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China. Viruses 2015;7(12):6400-11.
7.Bucak IH, Tepe B, Almış H, Köse A, Turgut M. Pediatri ve dermatoloji kliniklerinin ortak tanısı: El-ayak-ağız hastalığı olan otuz dokuz hastanın prospektif izlemi. Arch Turk Dermatol Venerology 2017;51:41-5.
8. Repass GL, Palmer WC, Stancampiano FF. Hand, foot, and mouth disease: Identifying and managing an acute viral syndrome. Cleve Clin J Med 2014;81:537-43.
9. Ho M, Chen ER, Hsu KH et al. An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med 1999;341:929-35.
10. Huang X, Wei H, Wu S et al. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013. SciRep 2015;5:8904.
11. Owatanapanich S, Wutthanarungsan R, Jaksupa W, Thisyakorn U. Risk factors for severe hand, foot and mouth disease. Southeast Asian J Trop Med Public Health 2015;46(3):449-59.
12. Gui J, Liu Z, Zhang T et al. Epidemiological Characteristics and Spatial-Temporal Clusters of Hand, Foot, and Mouth Disease in Zhejiang Province, China, 2008-2012. PLoSOne. 2015;10(9):e0139109.
13. Topkarcı Z, Erdoğan B, Yazıcı Z. El-Ayak-Ağız Hastalığının Klinik ve Demografik Özellikleri. Bakırköy Tıp Dergisi 2013;9(1):12-5.
14. Ooi MH, Wong SC, Mohan A et al. Identification and validation of clinical predictors for the risk of neurological involvement in children with hand, foot, and mouth disease in Sarawak. BMC Infect Dis 2009;9:3.
15. Upala P, Apidechkul T, Suttana W, Aimkosa R. Epidemiology of hand foot mouth disease in Northern Thailand in 2016: A prospective cohort study. Asian Pac J Trop Dis 2017;7(6):321-6. 16. Chan KP, Goh K, Chong C et al. Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore. Emerg Infect Dis 2003;9(1):78-85.
17. Ghosh SK, Bandyopadhyay D, Ghosh A et al. Mucocutaneous features of hand, foot, and mouth disease: A reappraisal from an outbreak in the city of Kolkata. Indian J Dermatol Venereol Leprol 2010;76:564-6.
18. Ekinci AP, Erbudak E, Baykal C. 2012 yılı Haziran ayında İstanbul’da el, ayak ve ağız hastalığı sıklığında önemli artış. Turkderm 2013;47(4):192-3.
19. Nag SS, Dutta A, Kumar Mandal R. Delayed cutaneous findings of hand, foot and mouth disease. Indian Pediatr 2016;53:42.

El, Ayak, Ağız Hastalığı Tanısı Alan Hastaların Klinik ve Demografik Olarak Analizi

Year 2018, Volume: 18 Issue: 1, 52 - 60, 30.03.2018

Fadime Kılınç Ayşe Akbaş

https://doi.org/10.17098/amj.409044

Abstract

Giriş: El ayak ağız hastalığı; ateş, el içi, ayak tabanı ve ağızda veziküler
lezyonlar ile karakterize, sıklıkla çocuklarda görülen viral bir enfeksiyondur.
Biz de; 2015-2017 tarihleri arasında Atatürk Eğitim ve Araştırma Hastanesi
Dermatoloji Polikliniği’ne başvuran ve el ayak ağız hastalığı tanısı alan 33
hastanın klinik özelliklerini retrospektif olarak araştırmayı amaçladık.
Materyal ve Metot: Dermatoloji polikliniğine başvuran ve klinik olarak
el ayak ağız hastalığı tanısı konulan 33 hasta yaş, cins, ateş, ağrı, yanma,
kaşıntı gibi semptomların varlığı, lezyonların lokalizasyonu, aile ve atopi
öyküsü açısından değerlendirildi.
Bulgular: Çalışmaya alınan 33 hastanın yaş ortalaması 12,21±9,45 yıl
(min-maks: 1-36) idi, 16 yaşından küçük 23 çocuk hasta ve 16 yaşından büyük 10
erişkin hasta vardı. Hastalık süresi ortalama 3,9±1,9 (min-maks: 1-7) olarak
hesaplandı. Hastaların %36,36’sı (n=12) erkek idi. 26 (%78,78) hastada ateş
öyküsü olup, 24’ünde ( %72,72) subfebril bir ateş (37,5 ) varken, 2’ sinde (%6,06)
39 derece idi. 5 hastada (%15,15) atopi öyküsü, 9 hastada (%27,27)ailede ve
yakın temasta olduğu kişilerde hastalık öyküsü vardı. Sekiz hasta boğaz ağrısı
(%24,24), 7 hasta(%21,21) kaşıntıdan şikayetçi idi. 31 hastada (%93,93 ) el içi
ve ayak tabanı, 24 hastada (%72,72) ağız içinde veziküler lezyonlar izlendi. En
sık tutulan bölge el içi idi (%96,96). Hastalık sonrası sadece 2 hastada (%6,06)
onikomadezis geliştiği görüldü.
Sonuç: Yapılan diğer araştırmalardan farklı olarak çalışmamızda; el ayak
ağız hastalığında kadın cinsiyet hakimiyeti gözlemledik. Çocuklarda daha sık
olmasına rağmen özellikle genç erişkinlerde de hastalığın görülebileceği,
el-ayak-ağız haricindeki vücut bölgelerini de tutabileceği, şiddetli formunda
uzun takiplerin önemli olduğu unutulmamalıdır.

Keywords

El ayak ağız hastalığı, enfeksiyon, viral

References

1. Uğraş M, Küçük Ö, Biçer S ve ark. İki yıllık periyot içinde el-ayak-ağız hastalığı olan çocukların değerlendirilmesi. J Kartal TR 2014;25:34-8.
2. Liu B, Luo L, Yan Set al. Clinical Features for Mild Hand, Foot and Mouth Disease in China. PLoS ONE 2015;10(8):e0135503.
3.Mehta KIS, Mahajan VK. Hand, Foot and Mouth Disease. Indian pediatrics 2010;47:345-6. 4. Chen SM, LiQiu, Du ZH et al. Spatial Clustering of Severe Hand-Foot-Mouth Disease Cases in Hainan Island, China. Japanese Journal of Infectious Diseases 2017;70(6):604-8.
5.Öncel EK, Nar I, Özsürekçi Y et al. Demographic and Clinical Findings in Children with Enteroviral Infection Outbreak. J Pediatr Inf 2013;7:97-101.
6.Zhuang ZC, Kou ZQ, Bai YJ et al. Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China. Viruses 2015;7(12):6400-11.
7.Bucak IH, Tepe B, Almış H, Köse A, Turgut M. Pediatri ve dermatoloji kliniklerinin ortak tanısı: El-ayak-ağız hastalığı olan otuz dokuz hastanın prospektif izlemi. Arch Turk Dermatol Venerology 2017;51:41-5.
8. Repass GL, Palmer WC, Stancampiano FF. Hand, foot, and mouth disease: Identifying and managing an acute viral syndrome. Cleve Clin J Med 2014;81:537-43.
9. Ho M, Chen ER, Hsu KH et al. An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med 1999;341:929-35.
10. Huang X, Wei H, Wu S et al. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013. SciRep 2015;5:8904.
11. Owatanapanich S, Wutthanarungsan R, Jaksupa W, Thisyakorn U. Risk factors for severe hand, foot and mouth disease. Southeast Asian J Trop Med Public Health 2015;46(3):449-59.
12. Gui J, Liu Z, Zhang T et al. Epidemiological Characteristics and Spatial-Temporal Clusters of Hand, Foot, and Mouth Disease in Zhejiang Province, China, 2008-2012. PLoSOne. 2015;10(9):e0139109.
13. Topkarcı Z, Erdoğan B, Yazıcı Z. El-Ayak-Ağız Hastalığının Klinik ve Demografik Özellikleri. Bakırköy Tıp Dergisi 2013;9(1):12-5.
14. Ooi MH, Wong SC, Mohan A et al. Identification and validation of clinical predictors for the risk of neurological involvement in children with hand, foot, and mouth disease in Sarawak. BMC Infect Dis 2009;9:3.
15. Upala P, Apidechkul T, Suttana W, Aimkosa R. Epidemiology of hand foot mouth disease in Northern Thailand in 2016: A prospective cohort study. Asian Pac J Trop Dis 2017;7(6):321-6. 16. Chan KP, Goh K, Chong C et al. Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore. Emerg Infect Dis 2003;9(1):78-85.
17. Ghosh SK, Bandyopadhyay D, Ghosh A et al. Mucocutaneous features of hand, foot, and mouth disease: A reappraisal from an outbreak in the city of Kolkata. Indian J Dermatol Venereol Leprol 2010;76:564-6.
18. Ekinci AP, Erbudak E, Baykal C. 2012 yılı Haziran ayında İstanbul’da el, ayak ve ağız hastalığı sıklığında önemli artış. Turkderm 2013;47(4):192-3.
19. Nag SS, Dutta A, Kumar Mandal R. Delayed cutaneous findings of hand, foot and mouth disease. Indian Pediatr 2016;53:42.

There are 17 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Research Articles
Authors	Fadime Kılınç This is me Ayşe Akbaş This is me
Publication Date	March 30, 2018
Published in Issue	Year 2018 Volume: 18 Issue: 1

Cite

APA	Kılınç, F., & Akbaş, A. (2018). Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis. Ankara Medical Journal, 18(1), 52-60. https://doi.org/10.17098/amj.409044
AMA	Kılınç F, Akbaş A. Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis. Ankara Med J. March 2018;18(1):52-60. doi:10.17098/amj.409044
Chicago	Kılınç, Fadime, and Ayşe Akbaş. “Clinical and Demographic Analysis of Patients With Hand, Foot and Mouth Disease Diagnosis”. Ankara Medical Journal 18, no. 1 (March 2018): 52-60. https://doi.org/10.17098/amj.409044.
EndNote	Kılınç F, Akbaş A (March 1, 2018) Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis. Ankara Medical Journal 18 1 52–60.
IEEE	F. Kılınç and A. Akbaş, “Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis”, Ankara Med J, vol. 18, no. 1, pp. 52–60, 2018, doi: 10.17098/amj.409044.
ISNAD	Kılınç, Fadime - Akbaş, Ayşe. “Clinical and Demographic Analysis of Patients With Hand, Foot and Mouth Disease Diagnosis”. Ankara Medical Journal 18/1 (March 2018), 52-60. https://doi.org/10.17098/amj.409044.
JAMA	Kılınç F, Akbaş A. Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis. Ankara Med J. 2018;18:52–60.
MLA	Kılınç, Fadime and Ayşe Akbaş. “Clinical and Demographic Analysis of Patients With Hand, Foot and Mouth Disease Diagnosis”. Ankara Medical Journal, vol. 18, no. 1, 2018, pp. 52-60, doi:10.17098/amj.409044.
Vancouver	Kılınç F, Akbaş A. Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis. Ankara Med J. 2018;18(1):52-60.