Astımlı Çocukların Serum D Vitamini ve Çinko Düzeyleri ile Klinik Bulguları Arasında Bir İlişki Var mı?

Year 2018, Volume: 18 Issue: 4, 528 - 536, 27.12.2018

Zehra Şule Haskoloğlu , Demet Altun

https://doi.org/10.17098/amj.499653

Abstract

Amaç: Vitamin D ve çinko eksikliğinin astım ile ilişkili olduğu bildirilmektedir. Bu çalışmada astımlı

çocukların klinik bulguları ile vitamin D ve çinko düzeyleri arasındaki ilişkiyi araştırmayı istedik.

Materyal ve Metot: Bu prospektif çalışmaya yaşları 5‐17 arasında değişen 149 astımlı ve 97 sağlıklı çocuk

dahil edildi. Tüm katılımcıların serum 25 hidroksivitamin D (25(OH)D) ve çinko düzeyleri ölçüldü, diyet

alışkanlıkları, bir yıldaki solunum yolu enfeksiyonu sıklıkları, hastane başvuruları ve güneş ışığına

maruziyet süreleri sorgulandı.

Bulgular: Astımlı çocukların serum D vitamini ve çinko düzeyleri sırasıyla (7,7±5,29 ng/ml), (64±16,3

mcg/dl) sağlıklı çocuklardan (12,3±12,87 ng/ml), (69±26,2 mcg/dl) belirgin şekilde düşük bulundu (p

<0,001) (p <0,015). Serum D vitamini düzeyinin 10ng/ml'nin altında olması ile enfeksiyon sıklığı arasında

ilişki bulunurken çinko düzeyi ile ilişki saptanmadı. Pulmoner fonksiyonlar, beslenme ile D vitamini

düzeyi arasında ilişki saptanmadı. Ancak güneşe maruziyet ile D vitamini düzeyi arasında bir ilişki

saptandı.

Sonuç: Sonuç: Bizim sonuçlarımız astımlı çocukların sağlıklı çocuklardan daha düşük D vitamini ve

çinko düzeyine sahip olduğunu göstermektedir. D vitamininin çok düşük düzeylerde olması artmış

enfeksiyon riski, daha çok tedavi ihtiyacı ve hastane yatışı ile ilişkili ulundu.

Keywords

Astımlı çocuk, vitamin D düzeyi, çinko düzeyi, klinik bulgular

Is There a Relationship between Clinical Symptoms of Asthmatic Children and Serum Levels of Vitamin D and Zinc?

Abstract

Objectives:
It is reported that deficiencies in vitamin D and zinc are associated with
asthma. In this study we aimed to investigate the relationship between clinic
findings of asthmatic children and vitamin D and zinc levels.
Materials and Methods: This
prospective study included a total of 149 asthmatics and 97 healthy children
with an age range of 5 to 17 years. All of the participants were evaluated for
serum levels of 25 -hydroxyvitamin D (25(OH)D) and zinc, dietary habits, the
rate of respiratory tract infections, hospital visits and levels of sunlight
exposure.
Results: Serum vitamin D and zinc
levels in asthmatic children (7.7±5.29 ng/ml), (64±16.3 mcg/dl) were
significantly lower than that in healthy children (12.3±12.87 ng/ml), (69±26.2
mcg/dl) (p< 0.015), respectively. A relationship was detected between the
frequency of infection and vitamin D level’s being <10ng/ml (p < 0.001),
while no relationship was detected between the frequency of infection and zinc
level. No relationship was detected between pulmonary function, nutrition and
the levels of vitamin D and zinc. However, a relationship was detected between
vitamin D levels and exposure to sunlight.
Conclusion: Our results showed that
asthmatic children had lower vitamin D and zinc levels than healthy children.
Very low levels of vitamin D were found to be associated with an increased rate
of infection and required more medication and hospitalization

Keywords

Asthmatic children, level of vitamin D, level of zinc, clinical symptoms

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