Research Article
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Evaluation of Vitamin D Levels According to Age, Sex and Seasonal Characteristics in Samsun

Year 2019, Volume: 19 Issue: 4, 769 - 775, 28.11.2019
https://doi.org/10.17098/amj.652002

Abstract

Objectives: The aim of this study was to determine whether vitamin D deficiency was present in adults who admitted to our hospital; To determine whether there is a difference between 25- hydroxy vitamin D (25-OH D) levels according to age, sex and seasons.
Materials and Methods: Between years 2018-2019; 23,773 patients who admitted to our hospital between winter and summer months were evaluated and age, sex and vitamin D levels were divided into groups according to months. Serum 25-OH D level <20 ng / ml was accepted as severe insufficiency, 20-30 ng / ml insufficiency, 30-100 ng / ml proficiency,> 100 toxicity. The data were evaluated by the SPSS 22.00 program. One-way Anova test was used in the evaluation of the data. p<0.05 was considered significant.
Results: In our study, 17,673 (74.34%) women and 6,100 (25.66%) men were included. The mean vitamin D levels of the patients (16.60 ± 10.83 ng / mL) were in women (16.51 ± 11.04 ng / mL) and in men (16.88 ± 10.19 ng / mL). When the mean vitamin D levels were compared to investigate the seasonal changes in vitamin D deficiency, it was statistically significant in both male and female patients among age groups.
Conclusion: In our study, severe vitamin D deficiency was found in patients admitted to our hospital. Vitamin D levels were lower in female and in winter.Considering that vitaminD deficiency is associated with many important diseases,foods enriched with vitamin D or vitamin D supplementation gain more importance.

References

  • IOM (Institute of Medicine). Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press; 2011. Mesci E, Mesci N, İçağasıoğlu A. Association of vitamin D deficiency with fatigue, daytime sleepiness, and physical activity level Turk J. Phys. Med. Rehab. 2016;62(3):222-8.
  • Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, et al. Epidemic influenza and vitamin D.Epidemiol. Infect. 2006;134:1129-40.
  • Schottker B, Haug U, Schomburg L, Kohrle J, Perna L, Muller H, et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J. Clin Nutr. 2013;97:782-93.
  • Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur. J. Clin. Nutr. 2011;65:1005-15.
  • Yap KS, Northcott M, Hoi AB, Morand EF, Nikpour M. Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort. Lupus. Sci. Med. 2015;2:e000064.
  • Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 2012;380:219-9.
  • Annweiler C, Beauchet O. Vitamin D-mentia: randomized clinical trials should be the next step. Neuroepidemiology 2011;37(3-4):249-58.
  • Llewellyn DJ, Langa KM, Lang IA. Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol 2009;(3):188-95.
  • Gezen-Ak D, Yılmazer S, Dursun E. Why vitamin D in Alzheimer's disease. The hypothesis. J Alzheimers Dis. 2014;40(2):257-69.
  • Banerjee A, Khemka VK, Ganguly A, Roy D, Ganguly U, Chakrabarti S. Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics. Int J Alzheimers Dis. 2015;2015:192747.
  • Diesel B, Radermacher J, Bureik M, Bernhardt R, Seifert M, Reichrath J, Fischer U, Meese E. Vitamin D (3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res. 2005;11(15):5370-80.
  • Holick MF. Vitamin D and brain health: the need for vitamin D supplementation and sensible sun exposure. J Intern Med. 2015;277(1):90-3.
  • Gerdhem P, Ringsberg KA, Obrant KJ, Akesson K. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int 2005;16:1425-31.
  • McCarty DE, Reddy A, Keigley Q, Kim PY, Marino AA. Vitamin D, race, and excessive daytime sleepiness. J Clin. Sleep Med 2012;8:693-7.
  • Gominak SC, Stumpf WE. The world epidemic of sleep disorders is linked to vitamin D deficiency. Med Hypotheses. 2012;79:132-5.
  • Roy S, Sherman A, Monari-Sparks MJ, Schweiker O, Hunter K. Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study). N. Am. J. Med. Sci. 2014;6:396-402.
  • Christodoulou S, Goula T, Ververidis A, Drosos G. Vitamin D and bone disease. Biomed Res Int 2013;1-6.
  • Atalay SG, Atalay R, Alkan BM, Fidan F, Bozkurt S, Aksekili H, Ardıçoğlu Ö. Vitamin D deficiency in adults with musculoskeletal pain. Turk J. Osteoporos. 2015;21:101-4.
  • Kumar GT, Chugh R, Eggersdorfer M. Poor vitamin D status in healthy population in India: a review of current evidence. Int J Vitam Nutr Res. 2015;85:1-7.
  • Chowdhury R, Kunutsor S, Vitezova A et al. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014;(348):1-13.
  • Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin. Proc. 2011;86:50-60.
  • Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080-6.
  • Vitezova A, Cartolano NS, Heeringa J, Zillikens MC, Hofman A, Franco OH, Kiefte-de Jong JC. Vitamin D and the risk of atrial fibrillation-The Rotterdam Study. PLoS-One 2015;10:e0125161.
  • Kanan RM, Al Saleh YM, Fakhoury HM, Adham M, Aljaser S, Tamimi W. Year-round vitamin D deficiency among Saudi female out-patients. Public Health Nutrition. 2013;16:544-548.
  • Açıkgöz A, Günay T, Uçku R. Vitamin D requirements and supplementation during pregnancy. TAF Preventive Medicine Bulletin. 2013;12:597-608.
  • Hekimsoy Z, Dinç G, Kafesciler S, Onur E, Güvenç Y, Pala T, Güçlü F, Özmen B. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health. 2010;10(1):782.
  • Uçar F, Yavuz Taşlıpınar M, Özden Soydaş A, Özcan N. Ankara Etlik İhtisas Eğitim ve Araştırma Hastanesine başvuran hastalarda 25-OH Vitamin D düzeyleri. Eur J. Basic Med Sci. 2012;2:12-5.
  • Çolak AA, Doğan N, Bozkurt Ü, Avcı R, Karademİrcİ İ. Vitamin D status in women in İzmir Tepecik Eğit. ve Araşt. Hast. Dergisi 2015;25(1):38-42.
  • Öğüş E, Sürer H, Kılınç AŞ, Fidancı V, Yılmaz G, Dindar N, Karakaş A. D Vitamini düzeylerinin aylara, cinsiyete ve yaşa göre değerlendirilmesi. Ankara Med J. 2015;15:1-5.
  • Taşkıran B, Cansu GB. Güneydoğu Bölgesinde Erişkinlerde D Vitamini Eksikliği. Osmangazi Tıp Dergisi. 2017;39(1):13-20.
  • Telo S, Kaman D, Akgöl G. Elazığ İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimlere Göre Değişimi. Fırat Med J. 2017;22(1):29-33.

Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimsel Özelliklere Göre Değerlendirilmesi

Year 2019, Volume: 19 Issue: 4, 769 - 775, 28.11.2019
https://doi.org/10.17098/amj.652002

Abstract

Amaç: Çalışmanın amacı hastanemize başvuran erişkinlerde D vitamini eksikliği olup olmadığını belirlemek; yaşa, cinsiyete ve mevsimlere göre 25- Hidroksi vitamin D (25-OH D) düzeyleri arasında fark olup olmadığını tespit etmektir.
Materyal ve Metot: 2018-2019 yılları arasında kış ve yaz mevsimi aylarında hastanemize başvuran 23.773 hasta çalışmaya alındı. Kişiler yaş, cinsiyet ve D vitamini düzeyleri aylara göre gruplara ayrıldı. Serum 25-OH D düzeyinin < 20 ng/ml olması ciddi yetersizlik, 20-30 ng/ml arası yetersizlik, 30–100 ng/ml arası yeterlilik, >100 toksisite olarak kabul edildi.Verilerin değerlendirilmesinde tek yönlü varyans analizi testi kullanıldı.İstatistiksel analiz için SPSS 22.0 programı kullanıldı. p<0,005 anlamlı kabul edildi.
Bulgular: Çalışmamızda kişilerin 17.673 (% 74,34) kadın ve 6.100 (% 25,66) erkek idi. Hastaların D vitamini düzeyleri ortalaması (16,60±10,83 ng/mL), kadınlarda (16,51±11,04 ng/mL), erkeklerde (16,88±10,19 ng/mL) idi. D vitamini yetersizliğinde mevsimsel değişiklikleri incelemek için ortalama D vitamini düzeyleri karşılaştırıldığında yaş grupları arasında hem erkek hem de kadın hastalarda istatistiksel olarak anlamlılık mevcuttu (p<0,001).
Sonuç: Hastanemize başvuran hastalarda ciddi D vitamini yetersizliği tespit edilmiştir. Kadın hastalarda ve kış aylarında ölçülen D vitamini düzeyleri daha düşüktü. D vitamin eksikliğinin birçok önemli hastalığa eşlik ettiği düşünülürse D vitamininden zenginleştirilmiş yiyecekler veya D vitamini destek tedavisi daha fazla önem kazanmaktadır.

References

  • IOM (Institute of Medicine). Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press; 2011. Mesci E, Mesci N, İçağasıoğlu A. Association of vitamin D deficiency with fatigue, daytime sleepiness, and physical activity level Turk J. Phys. Med. Rehab. 2016;62(3):222-8.
  • Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, et al. Epidemic influenza and vitamin D.Epidemiol. Infect. 2006;134:1129-40.
  • Schottker B, Haug U, Schomburg L, Kohrle J, Perna L, Muller H, et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J. Clin Nutr. 2013;97:782-93.
  • Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur. J. Clin. Nutr. 2011;65:1005-15.
  • Yap KS, Northcott M, Hoi AB, Morand EF, Nikpour M. Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort. Lupus. Sci. Med. 2015;2:e000064.
  • Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 2012;380:219-9.
  • Annweiler C, Beauchet O. Vitamin D-mentia: randomized clinical trials should be the next step. Neuroepidemiology 2011;37(3-4):249-58.
  • Llewellyn DJ, Langa KM, Lang IA. Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol 2009;(3):188-95.
  • Gezen-Ak D, Yılmazer S, Dursun E. Why vitamin D in Alzheimer's disease. The hypothesis. J Alzheimers Dis. 2014;40(2):257-69.
  • Banerjee A, Khemka VK, Ganguly A, Roy D, Ganguly U, Chakrabarti S. Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics. Int J Alzheimers Dis. 2015;2015:192747.
  • Diesel B, Radermacher J, Bureik M, Bernhardt R, Seifert M, Reichrath J, Fischer U, Meese E. Vitamin D (3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res. 2005;11(15):5370-80.
  • Holick MF. Vitamin D and brain health: the need for vitamin D supplementation and sensible sun exposure. J Intern Med. 2015;277(1):90-3.
  • Gerdhem P, Ringsberg KA, Obrant KJ, Akesson K. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int 2005;16:1425-31.
  • McCarty DE, Reddy A, Keigley Q, Kim PY, Marino AA. Vitamin D, race, and excessive daytime sleepiness. J Clin. Sleep Med 2012;8:693-7.
  • Gominak SC, Stumpf WE. The world epidemic of sleep disorders is linked to vitamin D deficiency. Med Hypotheses. 2012;79:132-5.
  • Roy S, Sherman A, Monari-Sparks MJ, Schweiker O, Hunter K. Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study). N. Am. J. Med. Sci. 2014;6:396-402.
  • Christodoulou S, Goula T, Ververidis A, Drosos G. Vitamin D and bone disease. Biomed Res Int 2013;1-6.
  • Atalay SG, Atalay R, Alkan BM, Fidan F, Bozkurt S, Aksekili H, Ardıçoğlu Ö. Vitamin D deficiency in adults with musculoskeletal pain. Turk J. Osteoporos. 2015;21:101-4.
  • Kumar GT, Chugh R, Eggersdorfer M. Poor vitamin D status in healthy population in India: a review of current evidence. Int J Vitam Nutr Res. 2015;85:1-7.
  • Chowdhury R, Kunutsor S, Vitezova A et al. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014;(348):1-13.
  • Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin. Proc. 2011;86:50-60.
  • Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080-6.
  • Vitezova A, Cartolano NS, Heeringa J, Zillikens MC, Hofman A, Franco OH, Kiefte-de Jong JC. Vitamin D and the risk of atrial fibrillation-The Rotterdam Study. PLoS-One 2015;10:e0125161.
  • Kanan RM, Al Saleh YM, Fakhoury HM, Adham M, Aljaser S, Tamimi W. Year-round vitamin D deficiency among Saudi female out-patients. Public Health Nutrition. 2013;16:544-548.
  • Açıkgöz A, Günay T, Uçku R. Vitamin D requirements and supplementation during pregnancy. TAF Preventive Medicine Bulletin. 2013;12:597-608.
  • Hekimsoy Z, Dinç G, Kafesciler S, Onur E, Güvenç Y, Pala T, Güçlü F, Özmen B. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health. 2010;10(1):782.
  • Uçar F, Yavuz Taşlıpınar M, Özden Soydaş A, Özcan N. Ankara Etlik İhtisas Eğitim ve Araştırma Hastanesine başvuran hastalarda 25-OH Vitamin D düzeyleri. Eur J. Basic Med Sci. 2012;2:12-5.
  • Çolak AA, Doğan N, Bozkurt Ü, Avcı R, Karademİrcİ İ. Vitamin D status in women in İzmir Tepecik Eğit. ve Araşt. Hast. Dergisi 2015;25(1):38-42.
  • Öğüş E, Sürer H, Kılınç AŞ, Fidancı V, Yılmaz G, Dindar N, Karakaş A. D Vitamini düzeylerinin aylara, cinsiyete ve yaşa göre değerlendirilmesi. Ankara Med J. 2015;15:1-5.
  • Taşkıran B, Cansu GB. Güneydoğu Bölgesinde Erişkinlerde D Vitamini Eksikliği. Osmangazi Tıp Dergisi. 2017;39(1):13-20.
  • Telo S, Kaman D, Akgöl G. Elazığ İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimlere Göre Değişimi. Fırat Med J. 2017;22(1):29-33.
There are 31 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Articles
Authors

Mahcube Çubukçu 0000-0003-4799-6848

Recai Acı This is me 0000-0002-3332-6619

Seçil Müderrisoğlu This is me 0000-0001-8802-5752

Publication Date November 28, 2019
Published in Issue Year 2019 Volume: 19 Issue: 4

Cite

APA Çubukçu, M., Acı, R., & Müderrisoğlu, S. (2019). Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimsel Özelliklere Göre Değerlendirilmesi. Ankara Medical Journal, 19(4), 769-775. https://doi.org/10.17098/amj.652002
AMA Çubukçu M, Acı R, Müderrisoğlu S. Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimsel Özelliklere Göre Değerlendirilmesi. Ankara Med J. November 2019;19(4):769-775. doi:10.17098/amj.652002
Chicago Çubukçu, Mahcube, Recai Acı, and Seçil Müderrisoğlu. “Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet Ve Mevsimsel Özelliklere Göre Değerlendirilmesi”. Ankara Medical Journal 19, no. 4 (November 2019): 769-75. https://doi.org/10.17098/amj.652002.
EndNote Çubukçu M, Acı R, Müderrisoğlu S (November 1, 2019) Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimsel Özelliklere Göre Değerlendirilmesi. Ankara Medical Journal 19 4 769–775.
IEEE M. Çubukçu, R. Acı, and S. Müderrisoğlu, “Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimsel Özelliklere Göre Değerlendirilmesi”, Ankara Med J, vol. 19, no. 4, pp. 769–775, 2019, doi: 10.17098/amj.652002.
ISNAD Çubukçu, Mahcube et al. “Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet Ve Mevsimsel Özelliklere Göre Değerlendirilmesi”. Ankara Medical Journal 19/4 (November 2019), 769-775. https://doi.org/10.17098/amj.652002.
JAMA Çubukçu M, Acı R, Müderrisoğlu S. Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimsel Özelliklere Göre Değerlendirilmesi. Ankara Med J. 2019;19:769–775.
MLA Çubukçu, Mahcube et al. “Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet Ve Mevsimsel Özelliklere Göre Değerlendirilmesi”. Ankara Medical Journal, vol. 19, no. 4, 2019, pp. 769-75, doi:10.17098/amj.652002.
Vancouver Çubukçu M, Acı R, Müderrisoğlu S. Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimsel Özelliklere Göre Değerlendirilmesi. Ankara Med J. 2019;19(4):769-75.