Evaluation of Vitamin D Levels According to Age, Sex and Seasonal Characteristics in Samsun

Year 2019, Volume: 19 Issue: 4, 769 - 775, 28.11.2019

Mahcube Çubukçu Recai Acı Seçil Müderrisoğlu

https://doi.org/10.17098/amj.652002

Cited By: 4

Abstract

Objectives: The aim of this study was to determine whether vitamin D deficiency was present in adults who admitted to our hospital; To determine whether there is a difference between 25- hydroxy vitamin D (25-OH D) levels according to age, sex and seasons.
Materials and Methods: Between years 2018-2019; 23,773 patients who admitted to our hospital between winter and summer months were evaluated and age, sex and vitamin D levels were divided into groups according to months. Serum 25-OH D level <20 ng / ml was accepted as severe insufficiency, 20-30 ng / ml insufficiency, 30-100 ng / ml proficiency,> 100 toxicity. The data were evaluated by the SPSS 22.00 program. One-way Anova test was used in the evaluation of the data. p<0.05 was considered significant.
Results: In our study, 17,673 (74.34%) women and 6,100 (25.66%) men were included. The mean vitamin D levels of the patients (16.60 ± 10.83 ng / mL) were in women (16.51 ± 11.04 ng / mL) and in men (16.88 ± 10.19 ng / mL). When the mean vitamin D levels were compared to investigate the seasonal changes in vitamin D deficiency, it was statistically significant in both male and female patients among age groups.
Conclusion: In our study, severe vitamin D deficiency was found in patients admitted to our hospital. Vitamin D levels were lower in female and in winter.Considering that vitaminD deficiency is associated with many important diseases,foods enriched with vitamin D or vitamin D supplementation gain more importance.

Keywords

Vitamin D, Age, Sex, Season

Samsun İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimsel Özelliklere Göre Değerlendirilmesi

Abstract

Amaç: Çalışmanın amacı hastanemize başvuran erişkinlerde D vitamini eksikliği olup olmadığını belirlemek; yaşa, cinsiyete ve mevsimlere göre 25- Hidroksi vitamin D (25-OH D) düzeyleri arasında fark olup olmadığını tespit etmektir.
Materyal ve Metot: 2018-2019 yılları arasında kış ve yaz mevsimi aylarında hastanemize başvuran 23.773 hasta çalışmaya alındı. Kişiler yaş, cinsiyet ve D vitamini düzeyleri aylara göre gruplara ayrıldı. Serum 25-OH D düzeyinin < 20 ng/ml olması ciddi yetersizlik, 20-30 ng/ml arası yetersizlik, 30–100 ng/ml arası yeterlilik, >100 toksisite olarak kabul edildi.Verilerin değerlendirilmesinde tek yönlü varyans analizi testi kullanıldı.İstatistiksel analiz için SPSS 22.0 programı kullanıldı. p<0,005 anlamlı kabul edildi.
Bulgular: Çalışmamızda kişilerin 17.673 (% 74,34) kadın ve 6.100 (% 25,66) erkek idi. Hastaların D vitamini düzeyleri ortalaması (16,60±10,83 ng/mL), kadınlarda (16,51±11,04 ng/mL), erkeklerde (16,88±10,19 ng/mL) idi. D vitamini yetersizliğinde mevsimsel değişiklikleri incelemek için ortalama D vitamini düzeyleri karşılaştırıldığında yaş grupları arasında hem erkek hem de kadın hastalarda istatistiksel olarak anlamlılık mevcuttu (p<0,001).
Sonuç: Hastanemize başvuran hastalarda ciddi D vitamini yetersizliği tespit edilmiştir. Kadın hastalarda ve kış aylarında ölçülen D vitamini düzeyleri daha düşüktü. D vitamin eksikliğinin birçok önemli hastalığa eşlik ettiği düşünülürse D vitamininden zenginleştirilmiş yiyecekler veya D vitamini destek tedavisi daha fazla önem kazanmaktadır.

Keywords

D vitamini, Yaş, Cinsiyet, Mevsim

References

• IOM (Institute of Medicine). Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press; 2011. Mesci E, Mesci N, İçağasıoğlu A. Association of vitamin D deficiency with fatigue, daytime sleepiness, and physical activity level Turk J. Phys. Med. Rehab. 2016;62(3):222-8.
• Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, et al. Epidemic influenza and vitamin D.Epidemiol. Infect. 2006;134:1129-40.
• Schottker B, Haug U, Schomburg L, Kohrle J, Perna L, Muller H, et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J. Clin Nutr. 2013;97:782-93.
• Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur. J. Clin. Nutr. 2011;65:1005-15.
• Yap KS, Northcott M, Hoi AB, Morand EF, Nikpour M. Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort. Lupus. Sci. Med. 2015;2:e000064.
• Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 2012;380:219-9.
• Annweiler C, Beauchet O. Vitamin D-mentia: randomized clinical trials should be the next step. Neuroepidemiology 2011;37(3-4):249-58.
• Llewellyn DJ, Langa KM, Lang IA. Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol 2009;(3):188-95.
• Gezen-Ak D, Yılmazer S, Dursun E. Why vitamin D in Alzheimer's disease. The hypothesis. J Alzheimers Dis. 2014;40(2):257-69.
• Banerjee A, Khemka VK, Ganguly A, Roy D, Ganguly U, Chakrabarti S. Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics. Int J Alzheimers Dis. 2015;2015:192747.
• Diesel B, Radermacher J, Bureik M, Bernhardt R, Seifert M, Reichrath J, Fischer U, Meese E. Vitamin D (3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res. 2005;11(15):5370-80.
• Holick MF. Vitamin D and brain health: the need for vitamin D supplementation and sensible sun exposure. J Intern Med. 2015;277(1):90-3.
• Gerdhem P, Ringsberg KA, Obrant KJ, Akesson K. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int 2005;16:1425-31.
• McCarty DE, Reddy A, Keigley Q, Kim PY, Marino AA. Vitamin D, race, and excessive daytime sleepiness. J Clin. Sleep Med 2012;8:693-7.
• Gominak SC, Stumpf WE. The world epidemic of sleep disorders is linked to vitamin D deficiency. Med Hypotheses. 2012;79:132-5.
• Roy S, Sherman A, Monari-Sparks MJ, Schweiker O, Hunter K. Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study). N. Am. J. Med. Sci. 2014;6:396-402.
• Christodoulou S, Goula T, Ververidis A, Drosos G. Vitamin D and bone disease. Biomed Res Int 2013;1-6.
• Atalay SG, Atalay R, Alkan BM, Fidan F, Bozkurt S, Aksekili H, Ardıçoğlu Ö. Vitamin D deficiency in adults with musculoskeletal pain. Turk J. Osteoporos. 2015;21:101-4.
• Kumar GT, Chugh R, Eggersdorfer M. Poor vitamin D status in healthy population in India: a review of current evidence. Int J Vitam Nutr Res. 2015;85:1-7.
• Chowdhury R, Kunutsor S, Vitezova A et al. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014;(348):1-13.
• Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin. Proc. 2011;86:50-60.
• Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080-6.
• Vitezova A, Cartolano NS, Heeringa J, Zillikens MC, Hofman A, Franco OH, Kiefte-de Jong JC. Vitamin D and the risk of atrial fibrillation-The Rotterdam Study. PLoS-One 2015;10:e0125161.
• Kanan RM, Al Saleh YM, Fakhoury HM, Adham M, Aljaser S, Tamimi W. Year-round vitamin D deficiency among Saudi female out-patients. Public Health Nutrition. 2013;16:544-548.
• Açıkgöz A, Günay T, Uçku R. Vitamin D requirements and supplementation during pregnancy. TAF Preventive Medicine Bulletin. 2013;12:597-608.
• Hekimsoy Z, Dinç G, Kafesciler S, Onur E, Güvenç Y, Pala T, Güçlü F, Özmen B. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health. 2010;10(1):782.
• Uçar F, Yavuz Taşlıpınar M, Özden Soydaş A, Özcan N. Ankara Etlik İhtisas Eğitim ve Araştırma Hastanesine başvuran hastalarda 25-OH Vitamin D düzeyleri. Eur J. Basic Med Sci. 2012;2:12-5.
• Çolak AA, Doğan N, Bozkurt Ü, Avcı R, Karademİrcİ İ. Vitamin D status in women in İzmir Tepecik Eğit. ve Araşt. Hast. Dergisi 2015;25(1):38-42.
• Öğüş E, Sürer H, Kılınç AŞ, Fidancı V, Yılmaz G, Dindar N, Karakaş A. D Vitamini düzeylerinin aylara, cinsiyete ve yaşa göre değerlendirilmesi. Ankara Med J. 2015;15:1-5.
• Taşkıran B, Cansu GB. Güneydoğu Bölgesinde Erişkinlerde D Vitamini Eksikliği. Osmangazi Tıp Dergisi. 2017;39(1):13-20.
• Telo S, Kaman D, Akgöl G. Elazığ İlinde D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimlere Göre Değişimi. Fırat Med J. 2017;22(1):29-33.