Effects of Endocrine Disruptors on Reproductive and Developmental Toxicity

Year 2022, , 166 - 174, 31.01.2022

Muazzez Tıkırdık , Dilek Ulusoy Karatopuk

https://doi.org/10.46237/amusbfd.978800

Abstract

Studies on endocrine disrupting substances that disrupt the function of the endocrine system, which is the center of the physiological and biological functions of the body, and cause adverse effects on the organism or on the next generations of this organism, have become a subject of interest in recent years. Studies on animal models and humans reveal that the mechanisms by which endocrine disruptors act involve different pathways. Endocrine disruptors; Pesticides, metals, plastic bottles, food packaging, detergents, cosmetic products and many materials used in daily life are natural or synthetic. There is a lot of evidence in the literature that these substances, which mimic the function of endogenous hormones, increase, decrease or block hormone production by manipulating cellular activity, affect many basic biological functions such as the nervous system, neurobehavior, immune and metabolic activity. In addition, endocrine disruptors have been reported to have negative effects on infertility, pregnancy, fetal development and female reproductive health. In this study, the effects and effects of endocrine disruptors such as bisphenol-A (BPA), polychlorinated biphenyls (PCB), diethylstilbestrol (DES), dichlorodiphenyltrichloroethane (DDT), phthalates, metals, ethanol and thalidomide, which are commonly associated with reproductive and developmental toxicity, It was aimed to review the mechanisms of these substances and it was determined that exposure to these substances has the potential to cause toxic damage even between generations in the long term

Keywords

Reproductive toxicity, Developmental toxicity, Endocrine disruptors

Endokrin Bozucuların Üreme ve Gelişim Toksisitesi Üzerine Etkileri

Abstract

Vücudun fizyolojik ve biyolojik işlevlerinin merkezi olan endokrin sistemin, işlevini bozan ve organizmada ya da bu organizmanın gelecek kuşaklarında olumsuz etkilere neden olan endokrin bozucu maddeler ile ilgili çalışmalar son yıllarda oldukça merak konusu haline gelmiştir. Hayvan modelleri ve insanlar üzerine yapılan araştırmalar, endokrin bozucuların etki ettiği mekanizmaların farklı yollar içerdiğini ortaya koymaktadır. Endokrin bozucular; pestisitler, metaller, plastik şişeler, gıda ambalajları, deterjanlar, kozmetik ürünleri ve günlük hayatta kullanılan birçok materyalin içeriğinde doğal veya sentetik olarak yer almaktadır. Endojen hormonların fonksiyonunu taklit eden, hücresel aktiviteyi manipüle ederek hormon üretimini attıran, azaltan veya bloke edebilen bu maddelerin sinir sistemi, nörodavranış, bağışıklık ve metabolik aktivite gibi birçok temel biyolojik fonksiyona etki ettiğine dair literatürde birçok kanıt bulunmaktadır. Bunun yanı sıra endokrin bozucuların infertilite, hamilelik, fetal gelişim ve kadın üreme sağlığı üzerinde de olumsuz etkilere sahip olduğu bildirilmiştir. Bu çalışmada yaygın olarak üreme ve gelişim toksisitesi ile ilişkilendirilen bisfenol-A (BPA), poliklorlu bifeniller (PCB), dietilstilbestrol (DES), pestisitlerin bir türevi olan diklorodifeniltrikloroetan (DDT), fitalatlar, metaller, etanol ve talidomid gibi endokrin bozucuların etkilerinin ve etki mekanizmalarının gözden geçirilmesi amaçlanmış ve bu maddelere maruziyetin uzun vadede kuşaklar arasında bile bir toksik hasar oluşturma potansiyeline sahip olduğu saptanmıştır.

Keywords

Üreme toksisitesi, Gelişim toksisitesi, Endokrin bozucular

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