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Yüksek Fruktozlu Mısır Şurubunun Karaciğer Yağlanması ve Obezite Gelişimi ile İlişkisi

Year 2021, Volume: 5 Issue: 2, 422 - 430, 29.05.2021
https://doi.org/10.46237/amusbfd.723499

Abstract

Yüksek fruktozlu mısır şurubu (YFMŞ) besin endüstrisinde tatlandırıcı olarak kullanılan, şeker ile karşılaştırıldığında daha az maliyetle kaliteli ürünlerin üretiminde fayda sağlayan FDA (Food and Drug Administration; Amerikan Gıda ve İlaç Dairesi) tarafından doğal olarak sınıflandırılan gıda katkı maddesidir. Yüksek fruktozlu mısır şurubu mısır nişastasının, kimyasal ve enzimatik hidroliz tekniklerinin kullanımı sonucunda sıvılaştırma, parçalama ve izomerizasyon süreçlerinden geçmesiyle üretilmektedir. Genellikle meşrubatlarda, hazır atıştırmalıklarda kullanımı yaygındır. Ürüne istenilen tat, doku ve uzun süreli raf ömrünü kazandırmada rol oynar. Teknolojinin gelişmesiyle 1970- 80’li yıllarda üretimi artmış ve obezite, şeker hastalığı, kardiyovasküler rahatsızlıklar gibi metabolik hastalıkların gelişimiyle ilişkilendirilmiştir. Yapılan araştırmalar sonucunda fazla miktarda YFMŞ içeren ürünlerin tüketimiyle hastalıkların gelişimi arasında pozitif yönde bir ilişki olduğu görülmüştür. Bu derlemede YFMŞ tüketimi ile non alkolik karaciğer hastalıkları ve obezite ilişkisi değerlendirilmiştir. Yüksek fruktozlu ürünlerin diyette kullanımıyla yağ metabolizmasını olumsuz yönde etkilemesi ve inflamatuvar sitokin, kolesterol seviyelerinde meydana getirdiği anlamlı artışla karaciğer yağlanmasını; vücut kütle indeksinde, bel çevresi ölçümünde oluşturduğu artışla da abdominal obezite oluşumunu tetiklediği araştırmalarla kanıtlanmıştır.

References

  • 1. Parker, K., Salas, M., & Nwosu, V. C. (2010). High fructose corn syrup: production, uses and public health concerns. Biotechnology and Molecular Biology Reviews, 5(5), 71-78.
  • 2. White, J. ( 2008). Straight talk about high-fructose corn syrup: what it is and what it ain't, The American Journal of Clinical Nutrition, 88(6) p. 1716–1721. doi:10.3945/ajcn.2008.25825B.
  • 3. Stanhope, K. L., Medici, V., Bremer, A. A., Lee, V., Lam, H. D., Nunez, M. V., Chen, G. X., Keim, N. L., & Havel, P. J. (2015). A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. The American journal of clinical nutrition, 101(6), 1144–1154. doi: 10.3945/ajcn.114.100461
  • 4. FDA: U.S.Food and Drugs Administration. (2019).High-fructose corn-syrup. Retrevied from: https://www.fda.gov/.
  • 5. Parker, K., Salas, M., Nwosu, V. C. (2010). High fructose corn syrup: Production, uses and public health concerns. Biotechnology and Molecular Biology Review. 5(5): 71 – 78.
  • 6. Duffey, K. J., & Popkin, B. M. (2008). High-fructose corn syrup: is this what's for dinner?. The American journal of clinical nutrition, 88(6), 1722S–1732S. doi.org/10.3945/ajcn.2008.25825C.
  • 7. Atış, F. (2012) . Yüksek fruktozlu mısır şurubu ve sukroz tüketiminin Wistar Albino cinsi sıçanlarda obezite üzerine etkisi. (Yayımlanmamış Yüksek Lisans Tezi) Süleyman Demirel Üniversitesi, Sağlık Bilimleri Enstitüsü Tıbbi Biokimya Anabilim Dalı, Isparta.
  • 8. Halk Sağlığı Genel Müd. Fruktoz ve nişasta bazlı şeker tüketiminin sağlık açısından etkileri: son verilerin derlemesi, https://www.foodelphi.com/fruktoz-ve-nisasta-bazli- seker-tuketiminin-saglik-acisindan-etkileri-son-verilerin-derlemesi-halk-sagligi-genel-mud/. adresinden edinilmiştir.
  • 9. Acay, A. (2015). Non Alkolik Yağlı Karaciğer Hastalığında Güncel Medikal Tedavi, Kocatepe Tıp Dergisi (Kocatepe Medical Journal )16: 67-76.
  • 10. Francini, F., Massa, M. L. &. Gagliardino, J. J. (2017). Fructose and Nonalcoholic Fatty Liver Disease. (Ed.), Victor R Preedy. Dietary Sugars: Chemistry, Analysis, Function and Effects (Chapter 43, p. 751 - 769). London. doi:1039/9781849734929-00751.
  • 11. Ackerman, Z., Oron-Herman, M., Grozovski, M., Rosenthal, T., Pappo, O., Link, G., (2005). Hepatic effects of blood pressure and plasma triglyceride reduction. Hypertension. 45:1012–1018. doi: 10.1161/01.HYP.0000164570.20420.67
  • 12. del Rocio Ibarra-Reynoso, L., López-Lemus, H. L., Garay-Sevilla, M. E., & Malacara, J. M. (2017). Effect of restriction of foods with high fructose corn syrup content on metabolic indices and fatty liver in obese children. Obesity facts, 10(4), 332-340.
  • 13. Nier, A., Brandt, A., Conzelmann, I., Özel, Y., Bergheim, I. (2018). Non-Alcoholic fatty liver disease in overweight children: role of fructose intake and dietary pattern, Nutrients. 10(9):1329. doi: 10.3390/nu10091329.
  • 14. Schattenberg, J. M., & Bergheim, I. (2019). Nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD), Nutrients. 11(3): 588. doi: 10.3390/nu11030588.
  • 15. Mock, K., Lateef, S., Benedito, V.A., Toua, J. C. High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. J Nutr Biochem.2017;39:32–39.
  • 16. Olsen, N. J, Heitmann, B. L. (2009) Intake of calorically sweetened beverages and obesity. Obes Rev.;10(1):68-75. doi:10.1111/j.1467-789X.2008.00523.x
  • 17. Cantoral, A., Contreras-Manzano, A., Luna-Villa, L., Batis, C., Roldán-Valadez, E. A., Ettinger, A. S., et al. (2019). Dietary sources of fructose and its association with fatty liver in Mexican young adults. Nutrients, 11(3), 522.
  • 18. Sadowska, J., & Rygielska, M. (2019). The effect of high fructose corn syrup on the plasma insulin and leptin concentration, body weight gain and fat accumulation in rat. Advances in Clinical and Experimental Medicine, 28(7), 879-884.
  • 19. Toop, C. R., Muhlhausler, B. S., O'Dea, K., & Gentili, S. (2017). Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS‐55) on adiposity and hepatic lipid composition in rat offspring. The Journal of physiology, 595(13), 4379-4398.
  • 20. Kuzma, J. N., Cromer, G., Hagman, D. K., Breymeyer, K. L., Roth, C. L., Foster-Schubert, K. E., et al. (2015). No difference in ad libitum energy intake in healthy men and women consuming beverages sweetened with fructose, glucose, or high-fructose corn syrup: a randomized trial. The American journal of clinical nutrition, 102(6), 1373-1380.
  • 21. Akram, M., & Hamid, A. (2013). Mini review on fructose metabolism. Obesity research & clinical practice, 7(2), e89-e94.
  • 22. George, A., Samara, J. (2004). Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 79(4): 537-43. doi: 10.1093/ajcn/79.4.537
  • 23. Heidari-Beni, M., Rafie, N., Akbarian, S. A., & Kelishadi, R. (2019). Sugar-Sweetened Beverages Consumption and Long-Term Side Effects on Nutrition and Health Outcomes in Pediatric Age Group. In Value-Added Ingredients and Enrichments of Beverages (pp. 265-283). Academic Press.
  • 24. Frantsve‐Hawley, J., Bader, J. D., Welsh, J. A., & Wright, J. T. (2017). A systematic review of the association between consumption of sugar‐containing beverages and excess weight gain among children under age 12. Journal of public health dentistry, 77, S43-S66.
  • 25. Cantoral, A., Téllez‐Rojo, M. M., Ettinger, A. S., Hu, H., Hernández‐Ávila, M., & Peterson, K. (2016). Early introduction and cumulative consumption of sugar‐sweetened beverages during the pre‐school period and risk of obesity at 8–14 years of age. Pediatric obesity, 11(1), 68-74.
  • 26. Pérez-Morales, E., Bacardí-Gascón, M., & Jiménez-Cruz, A. (2013). Sugar-sweetened beverage intake before 6 years of age and weight or BMI status among older children; systematic review of prospective studies. Nutricion hospitalaria, 28(1), 47-51.
  • 27. Leˆ, K. A., Faeh, D., Stettler, R., Ith, M., Kreis, R., Vermathen, P., ... & Tappy, L. (2006). A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. The American journal of clinical nutrition, 84(6), 1374-1379.
  • 28. Melanson, K. J., Zukley, L., Lowndes, J., Nguyen, V., Angelopoulos, T. J., & Rippe, J. M. (2007). Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition, 23(2), 103-112.
  • 29. Lin, W. T., Chan, T. F., Huang, H. L., Lee, C. Y., Tsai, S., Wu, P. W., ... & Lee, C. H. (2016). Fructose-rich beverage intake and central adiposity, uric acid, and pediatric insulin resistance. The Journal of pediatrics, 171, 90-96.
  • 30. T.C. Sağlık Bakanlığı. Türkiye Beslenme Rehberi (TÜBER). Sağlık Bakanlığı Yayınları, Ankara, (2016). https://dosyasb.saglik.gov.tr/Eklenti/10915,tuber-turkiye-beslenme- rehberipdf.pdf. adresinden alınmıştır.

High Fructose Corn Syrup Association with Progression of Fatty Liver Disease and Obesity

Year 2021, Volume: 5 Issue: 2, 422 - 430, 29.05.2021
https://doi.org/10.46237/amusbfd.723499

Abstract

High fructose corn syrup (HFCS) is a food additive which classified as natural, used in food industry instead of sugar, can provide low cost and high quality. Generally, it is produced with condensation, isomerization and disintegration processes with use of corn starch, chemical and enzymatic hydrolysis techniques. It plays a role to provide the desirable taste, texture and long term shelf life to product. With developed technology, by 1970s and 1980s, production of HFCS increase and it is associated with progression of metabolic dieases such as obesity, diabetes, cardivascular diseases. Researches show that ingestion of HFCS in excessive amounts is related with metabolic diseases positively. In this review, relationship between consumption of HFCS and nonalcoholic fatty liver diseases and obesity was evaluated. Use of products include HFCS in diet can progress fatty liver in terms of increase of inflamatuvar cytocins, cholesterol and effect on lipid metabolism negatively. Also it is proved to stimulate abdominal obesity with providing increasing waist circumference and body mass index (BMI).      

References

  • 1. Parker, K., Salas, M., & Nwosu, V. C. (2010). High fructose corn syrup: production, uses and public health concerns. Biotechnology and Molecular Biology Reviews, 5(5), 71-78.
  • 2. White, J. ( 2008). Straight talk about high-fructose corn syrup: what it is and what it ain't, The American Journal of Clinical Nutrition, 88(6) p. 1716–1721. doi:10.3945/ajcn.2008.25825B.
  • 3. Stanhope, K. L., Medici, V., Bremer, A. A., Lee, V., Lam, H. D., Nunez, M. V., Chen, G. X., Keim, N. L., & Havel, P. J. (2015). A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. The American journal of clinical nutrition, 101(6), 1144–1154. doi: 10.3945/ajcn.114.100461
  • 4. FDA: U.S.Food and Drugs Administration. (2019).High-fructose corn-syrup. Retrevied from: https://www.fda.gov/.
  • 5. Parker, K., Salas, M., Nwosu, V. C. (2010). High fructose corn syrup: Production, uses and public health concerns. Biotechnology and Molecular Biology Review. 5(5): 71 – 78.
  • 6. Duffey, K. J., & Popkin, B. M. (2008). High-fructose corn syrup: is this what's for dinner?. The American journal of clinical nutrition, 88(6), 1722S–1732S. doi.org/10.3945/ajcn.2008.25825C.
  • 7. Atış, F. (2012) . Yüksek fruktozlu mısır şurubu ve sukroz tüketiminin Wistar Albino cinsi sıçanlarda obezite üzerine etkisi. (Yayımlanmamış Yüksek Lisans Tezi) Süleyman Demirel Üniversitesi, Sağlık Bilimleri Enstitüsü Tıbbi Biokimya Anabilim Dalı, Isparta.
  • 8. Halk Sağlığı Genel Müd. Fruktoz ve nişasta bazlı şeker tüketiminin sağlık açısından etkileri: son verilerin derlemesi, https://www.foodelphi.com/fruktoz-ve-nisasta-bazli- seker-tuketiminin-saglik-acisindan-etkileri-son-verilerin-derlemesi-halk-sagligi-genel-mud/. adresinden edinilmiştir.
  • 9. Acay, A. (2015). Non Alkolik Yağlı Karaciğer Hastalığında Güncel Medikal Tedavi, Kocatepe Tıp Dergisi (Kocatepe Medical Journal )16: 67-76.
  • 10. Francini, F., Massa, M. L. &. Gagliardino, J. J. (2017). Fructose and Nonalcoholic Fatty Liver Disease. (Ed.), Victor R Preedy. Dietary Sugars: Chemistry, Analysis, Function and Effects (Chapter 43, p. 751 - 769). London. doi:1039/9781849734929-00751.
  • 11. Ackerman, Z., Oron-Herman, M., Grozovski, M., Rosenthal, T., Pappo, O., Link, G., (2005). Hepatic effects of blood pressure and plasma triglyceride reduction. Hypertension. 45:1012–1018. doi: 10.1161/01.HYP.0000164570.20420.67
  • 12. del Rocio Ibarra-Reynoso, L., López-Lemus, H. L., Garay-Sevilla, M. E., & Malacara, J. M. (2017). Effect of restriction of foods with high fructose corn syrup content on metabolic indices and fatty liver in obese children. Obesity facts, 10(4), 332-340.
  • 13. Nier, A., Brandt, A., Conzelmann, I., Özel, Y., Bergheim, I. (2018). Non-Alcoholic fatty liver disease in overweight children: role of fructose intake and dietary pattern, Nutrients. 10(9):1329. doi: 10.3390/nu10091329.
  • 14. Schattenberg, J. M., & Bergheim, I. (2019). Nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD), Nutrients. 11(3): 588. doi: 10.3390/nu11030588.
  • 15. Mock, K., Lateef, S., Benedito, V.A., Toua, J. C. High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. J Nutr Biochem.2017;39:32–39.
  • 16. Olsen, N. J, Heitmann, B. L. (2009) Intake of calorically sweetened beverages and obesity. Obes Rev.;10(1):68-75. doi:10.1111/j.1467-789X.2008.00523.x
  • 17. Cantoral, A., Contreras-Manzano, A., Luna-Villa, L., Batis, C., Roldán-Valadez, E. A., Ettinger, A. S., et al. (2019). Dietary sources of fructose and its association with fatty liver in Mexican young adults. Nutrients, 11(3), 522.
  • 18. Sadowska, J., & Rygielska, M. (2019). The effect of high fructose corn syrup on the plasma insulin and leptin concentration, body weight gain and fat accumulation in rat. Advances in Clinical and Experimental Medicine, 28(7), 879-884.
  • 19. Toop, C. R., Muhlhausler, B. S., O'Dea, K., & Gentili, S. (2017). Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS‐55) on adiposity and hepatic lipid composition in rat offspring. The Journal of physiology, 595(13), 4379-4398.
  • 20. Kuzma, J. N., Cromer, G., Hagman, D. K., Breymeyer, K. L., Roth, C. L., Foster-Schubert, K. E., et al. (2015). No difference in ad libitum energy intake in healthy men and women consuming beverages sweetened with fructose, glucose, or high-fructose corn syrup: a randomized trial. The American journal of clinical nutrition, 102(6), 1373-1380.
  • 21. Akram, M., & Hamid, A. (2013). Mini review on fructose metabolism. Obesity research & clinical practice, 7(2), e89-e94.
  • 22. George, A., Samara, J. (2004). Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 79(4): 537-43. doi: 10.1093/ajcn/79.4.537
  • 23. Heidari-Beni, M., Rafie, N., Akbarian, S. A., & Kelishadi, R. (2019). Sugar-Sweetened Beverages Consumption and Long-Term Side Effects on Nutrition and Health Outcomes in Pediatric Age Group. In Value-Added Ingredients and Enrichments of Beverages (pp. 265-283). Academic Press.
  • 24. Frantsve‐Hawley, J., Bader, J. D., Welsh, J. A., & Wright, J. T. (2017). A systematic review of the association between consumption of sugar‐containing beverages and excess weight gain among children under age 12. Journal of public health dentistry, 77, S43-S66.
  • 25. Cantoral, A., Téllez‐Rojo, M. M., Ettinger, A. S., Hu, H., Hernández‐Ávila, M., & Peterson, K. (2016). Early introduction and cumulative consumption of sugar‐sweetened beverages during the pre‐school period and risk of obesity at 8–14 years of age. Pediatric obesity, 11(1), 68-74.
  • 26. Pérez-Morales, E., Bacardí-Gascón, M., & Jiménez-Cruz, A. (2013). Sugar-sweetened beverage intake before 6 years of age and weight or BMI status among older children; systematic review of prospective studies. Nutricion hospitalaria, 28(1), 47-51.
  • 27. Leˆ, K. A., Faeh, D., Stettler, R., Ith, M., Kreis, R., Vermathen, P., ... & Tappy, L. (2006). A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. The American journal of clinical nutrition, 84(6), 1374-1379.
  • 28. Melanson, K. J., Zukley, L., Lowndes, J., Nguyen, V., Angelopoulos, T. J., & Rippe, J. M. (2007). Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition, 23(2), 103-112.
  • 29. Lin, W. T., Chan, T. F., Huang, H. L., Lee, C. Y., Tsai, S., Wu, P. W., ... & Lee, C. H. (2016). Fructose-rich beverage intake and central adiposity, uric acid, and pediatric insulin resistance. The Journal of pediatrics, 171, 90-96.
  • 30. T.C. Sağlık Bakanlığı. Türkiye Beslenme Rehberi (TÜBER). Sağlık Bakanlığı Yayınları, Ankara, (2016). https://dosyasb.saglik.gov.tr/Eklenti/10915,tuber-turkiye-beslenme- rehberipdf.pdf. adresinden alınmıştır.
There are 30 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review Articles
Authors

Aylin Seylam This is me 0000-0003-4705-8042

Başak Karataş This is me 0000-0002-6966-8733

Ayça Çelebi 0000-0001-9955-6997

Publication Date May 29, 2021
Published in Issue Year 2021 Volume: 5 Issue: 2

Cite

APA Seylam, A., Karataş, B., & Çelebi, A. (2021). Yüksek Fruktozlu Mısır Şurubunun Karaciğer Yağlanması ve Obezite Gelişimi ile İlişkisi. Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 5(2), 422-430. https://doi.org/10.46237/amusbfd.723499