Serebral Palside Botulinum Toksin Enjeksiyonu Sonrası Güncel Fizyoterapi ve Rehabilitasyon Yaklaşımları
Year 2024,
Volume: 8 Issue: 3, 352 - 362, 30.09.2024
Pelin Atalan Efkere
,
Bülent Elbasan
Abstract
Serebral Palsi (SP) yenidoğanın gelişmemiş beyninde meydana gelen kalıcı bir hasarın ardından postür ve harekette problemlerle sonuçlanan bir dizi bozukluğu ifade eden şemsiye bir terimdir. SP’de önemli ve oldukça sık görülen bir bozukluk olan spastisitenin yönetiminde Botulinum Toksin (BoNT) enjeksiyonlarından sıklıkla faydalanılmaktadır. BoNT enjeksiyonları tek başına lokal spastisiteyi belli bir süreliğine azaltsa da, elde edilen kazanımların korunması ve fonksiyonların iyileştirilmesi için çeşitli fizyoterapi ve rehabilitasyon uygulamalarına ihtiyaç duyulur. Ancak literatürde BoNT enjeksiyonları sonrası fizyoterapi ve rehabilitasyon uygulamalarına yönelik bir uzlaşı bulunmamaktadır. Bu derlemenin amacı SP’li bireylerde spastik kaslara yapılan BoNT enjeksiyonlarının ardından uygulanan güncel fizyoterapi ve rehabilitasyon yaklaşımlarının özetlenmesi, literatürdeki yerlerinin kanıt düzeyleri vurgulanarak incelenmesi ve etkinliklerinin özetlenmesidir.
References
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2. Rosenbaum, P., Paneth, N., Leviton, A., Goldstein, M., Bax, M., Damiano, D., & et al. (2007). A report: the
definition and classification of cerebral palsy April 2006. Developmental Medicine & Child Neurology,
109(suppl 109), 8-14.
- 3. Cans, C., Dolk, H., Platt, M. J., & Colver, A. (2007). Recommendations from the SCPE collaborative group for
defining and classifying cerebral palsy. Developmental Medicine & Child Neurology, 49, 35.
- 4. Bar-On, L., Molenaers, G., Aertbeliën, E., Van Campenhout, A., Feys, H., Nuttin, B., & et al. (2015). Spasticity
and its contribution to hypertonia in cerebral palsy. BioMed Research International, 2015.
- 5. Lance, J. W. (1980). Symposium synopsis. Spasticity: Disordered Motor Control, 487-489.
- 6. Shamsoddini, A., Amirsalari, S., Hollisaz, M.-T., Rahimnia, A., & Khatibi-Aghda, A. (2014). Management of
spasticity in children with cerebral palsy. Iranian Journal of Pediatrics, 24(4), 345.
- 7. Tickner, N., Apps, J. R., Keady, S., & Sutcliffe, A. G. (2012). An overview of drug therapies used in the
treatment of dystonia and spasticity in children. Archives of Disease in Childhood-Education and Practice,
97(6), 230-235.
- 8. Simon, O., & Yelnik, A. (2010). Managing spasticity with drugs. European Journal of Physical and
Rehabilitation Medicine, 46(3), 401-410.
- 9. Koman, L. A., Mooney III, J. F., Smith, B. P., Goodman, A., & Mulvaney, T. (1994). Management of spasticity in
cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial. Journal of
Pediatric Orthopaedics, 14(3), 299-303.
- 10. Novak, I., Morgan, C., Fahey, M., Finch-Edmondson, M., Galea, C., Hines & et al. (2020). State of the
evidence traffic lights 2019: systematic review of interventions for preventing and treating children with
cerebral palsy. Current Neurology and Neuroscience Reports, 20, 1-21.
- 11. Novak, I., Mcintyre, S., Morgan, C., Campbell, L., Dark, L., Morton, N., & et al. (2013). A systematic review of
interventions for children with cerebral palsy: state of the evidence. Developmental Medicine & Child
Neurology, 55(10), 885-910.
- 12. Mathevon, L., Bonan, I., Barnais, J.-L., Boyer, F., & Dinomais, M. (2019). Adjunct therapies to improve
outcomes after botulinum toxin injection in children: A systematic review. Annals of Physical and
Rehabilitation Medicine, 62(4), 283-290.
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management and neurophysiology: Cambridge University Press.
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problems in cerebral palsy: John Wiley & Sons.
- 15. Klingels, K., Demeyere, I., Jaspers, E., De Cock, P., Molenaers, G., Boyd, R., & et al. (2012). Upper limb
impairments and their impact on activity measures in children with unilateral cerebral palsy. European
Journal of Paediatric Neurology, 16(5), 475-484.
- 16. Scott, A. B. (1980). Botulinum toxin injection into extraocular muscles as an alternative to strabismus
surgery. Ophthalmology, 87(10), 1044–1049.
- 17. Whurr, R., Lorch, M., Fontana, H., Brookes, G., Lees, A., & Marsden, C. (1993). The use of botulinum toxin in the treatment of adductor spasmodic dysphonia. Journal of Neurology, Neurosurgery & Psychiatry, 56(5),
526-530.
- 18. Aoki, K., & Guyer, B. (2001). Botulinum toxin type A and other botulinum toxin serotypes: a comparative
review of biochemical and pharmacological actions. European Journal of Neurology, 8, 21-29.
- 19. Cosgrove, A., & Graham, H. (1994). Botunum toxin a prevents the development of contractures in the
hereditary spastc mouse. Developmental Medicine & Child Neurology, 36(5), 379-385.
- 20. Kay, R. M., Rethlefsen, S. A., Fern-Buneo, A., Wren, T. A., & Skaggs, D. L. (2004). Botulinum toxin as an
adjunct to serial casting treatment in children with cerebral palsy. The Journal of Bone & Joint Surgery 86(11),
2377-2384.
- 21. Lee, S. J., Sung, I. Y., Jang, D. H., Yi, J. H., Lee, J. H., & Ryu, J. S. (2011). The effect and complication of
botulinum toxin type A injection with serial casting for the treatment of spastic equinus foot. Annals of
Rehabilitation Medicine, 35(3), 344-353.
- 22. Picelli, A., Santamato, A., Chemello, E., Cinone, N., Cisari, C., Gandolfi, M., & et al. (2019). Adjuvant treatments associated with botulinum toxin injection for managing spasticity: An overview of the literature.
Annals of Physical and Rehabilitation Medicine, 62(4), 291-296.
- 23. Valentine, J., Stannage, K., Fabian, V., Ellis, K., Reid, S., & et al. (2016). Muscle histopathology in children with
spastic cerebral palsy receiving botulinum toxin type A. Muscle & Nerve, 53(3), 407-414.
- 24. De Beukelaer, N., Weide, G., Huyghe, E., Vandekerckhove, I., Hanssen, B., Peeters, N. et al. (2022). Reduced
cross-sectional muscle growth six months after botulinum toxin type-A injection in children with spastic
cerebral palsy. Toxins, 14(2), 139.
- 25. Bovend'Eerdt, T. J., Newman, M., Barker, K., Dawes, H., Minelli, C., & Wade, D. T. (2008). The effects of
stretching in spasticity: a systematic review. Archives of Physical Medicine and Rehabilitation, 89(7), 1395-1406.
- 26. Smania, N., Picelli, A., Munari, D., Geroin, C., Ianes, P., Waldner, A., & Gandolfi, M. (2010). Rehabilitation
procedures in the management of spasticity. Eur J Phys Rehabil Med, 46(3), 423-438.
- 27. Mills, P. B., Finlayson, H., Sudol, M., & O’Connor, R. (2016). Systematic review of adjunct therapies to
improve outcomes following botulinum toxin injection for treatment of limb spasticity. Clinical Rehabilitation,
30(6), 537-548.
- 28. Franceschini, M., Iocco, M., Molteni, F., Santamato, A., & Smania, N. (2014). Management of stroke patients
submitted to botulinum toxin type A therapy: a Delphi survey of an Italian expert panel of specialist injectors.
European Journal of Physical and Rehabilitation Medicine, 50(5), 525-533.
- 29. Picelli, A., Smania, N., Storti, I., Munari, D., Fontana, C., Fiaschi, A., & et al. (2011). Immediate versus delayed
electrical stimulation boosts botulinum toxin effect: A pilot study. Movement Disorders, 26(9), 1785-1786.
- 30. Aydil, S., Akpinar, F. M., Akpinar, E., Beng, K., & Yagmurlu, M. F. (2019). Effectiveness of multilevel botulinum
toxin A injection with integrated treatment program on spasticity reduction in non-ambulatory young
children with cerebral palsy. Medical Principles and Practice, 28(4), 309-314.
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Neurorehabilitation with versus without resistance training after botulinum toxin treatment in children with
cerebral palsy: A randomized pilot study. NeuroRehabilitation, 30(4), 277-286.
- 32. Lannin, N. A., Novak, I., & Cusick, A. (2007). A systematic review of upper extremity casting for children
and adults with central nervous system motor disorders. Clinical Rehabilitation, 21(11), 963-976.
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Cerebral Palsy: a systematic review with meta-analysis. BMC Pediatrics, 20, 1-23.
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Therapy in Health Care, 14(2), 99-106.
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combined with casting on the equinus gait of children with cerebral palsy. The Journal of Bone & Joint
Surgery British Volume, 92(8), 1152-1159.
- 37. Tedroff, K., Granath, F., Forssberg, H., & Haglund‐Akerlind, Y. (2009). Long‐term effects of botulinum toxin A
in children with cerebral palsy. Developmental Medicine & Child Neurology, 51(2), 120-127.
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ambulatory children with cerebral palsy: a systematic review and meta-analysis. American Journal of
Physical Medicine & Rehabilitation, 98(9), 759-770.
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Therapy, 15(2), 97-132.
- 40. Garbellini, S., Robert, Y., Randall, M., Elliott, C., & Imms, C. (2018). Rationale for prescription, and
effectiveness of, upper limb orthotic intervention for children with cerebral palsy: a systematic review.
Disability and Rehabilitation, 40(12), 1361-1371.
- 41. Santamato, A., Notarnicola, A., Panza, F., Ranieri, M., Micello, M. F., Manganotti, P., & et al. (2013). SBOTE study: extracorporeal shock wave therapy versus electrical stimulation after botulinum toxin type a injection
for post-stroke spasticity–a prospective randomized trial. Ultrasound in Medicine & Biology, 39(2), 283-291.
- 42. Wu, Y.-T., Chang, C.-N., Chen, Y.-M.,& Hu, G.-C. (2017). Comparison of the effect of focused and radial
extracorporeal shock waves on spastic equinus in patients with stroke: a randomized controlled trial.
European Journal of Physical and Rehabilitation Medicine, 54(4), 518-525.
- 43. Emara, H. A., Al-Johani, A. H., Khaled, O. A., Ragab, W. M., & Al-Shenqiti, A. M. (2022). Effect of
extracorporeal shock wave therapy on spastic equinus foot in children with unilateral cerebral palsy. Journal
of Taibah University Medical Sciences, 17(5), 794-804.
- 44. Vidal, X., Morral, A., Costa, L., & Tur, M. (2011). Radial extracorporeal shock wave therapy (rESWT) in the treatment of spasticity in cerebral palsy: a randomized, placebo-controlled clinical trial. NeuroRehabilitation, 29(4), 413-419.
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on muscle spasticity in patients with hemiplegia: a pilot study. Electromyography and Clinical
Neurophysiology, 46(4), 247.
- 46. Ansari, N., Naghdi, S., Bagheri, H., & Ghassabi, H. (2007). Therapeutic ultrasound in the treatment of ankle
plantarflexor spasticity in a unilateral stroke population: a randomized, single-blind, placebo-controlled trial.
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Current Physiotherapy and Rehabilitation Approaches After Botulinum Toxin Injection in Cerebral Palsy
Year 2024,
Volume: 8 Issue: 3, 352 - 362, 30.09.2024
Pelin Atalan Efkere
,
Bülent Elbasan
Abstract
Cerebral Palsy (CP) is an umbrella term that refers to a set of disorders that result in problems with posture and movement following permanent damage to the newborn's immature brain. Botulinum Toxin (BoNT) injections are frequently used in the management of spasticity, which is an important and very common disorder in CP. Although BoNT injections alone reduce local spasticity for a certain period of time, various physiotherapy and rehabilitation applications are needed to maintain the gains achieved and improve functions. However, there is no consensus in the literature regarding physiotherapy and rehabilitation practices after BoNT injections. The aim of this review is to summarize the current physiotherapy and rehabilitation approaches applied after BoNT injections into spastic muscles in individuals with CP, to examine their place in the literature by emphasizing their level of evidence, and to summarize their effectiveness.
References
- 1. Bax, M. C. (1964). Terminology and classification of cerebral palsy. Developmental Medicine & Child Neurology, 6(3), 295-297.
2. Rosenbaum, P., Paneth, N., Leviton, A., Goldstein, M., Bax, M., Damiano, D., & et al. (2007). A report: the
definition and classification of cerebral palsy April 2006. Developmental Medicine & Child Neurology,
109(suppl 109), 8-14.
- 3. Cans, C., Dolk, H., Platt, M. J., & Colver, A. (2007). Recommendations from the SCPE collaborative group for
defining and classifying cerebral palsy. Developmental Medicine & Child Neurology, 49, 35.
- 4. Bar-On, L., Molenaers, G., Aertbeliën, E., Van Campenhout, A., Feys, H., Nuttin, B., & et al. (2015). Spasticity
and its contribution to hypertonia in cerebral palsy. BioMed Research International, 2015.
- 5. Lance, J. W. (1980). Symposium synopsis. Spasticity: Disordered Motor Control, 487-489.
- 6. Shamsoddini, A., Amirsalari, S., Hollisaz, M.-T., Rahimnia, A., & Khatibi-Aghda, A. (2014). Management of
spasticity in children with cerebral palsy. Iranian Journal of Pediatrics, 24(4), 345.
- 7. Tickner, N., Apps, J. R., Keady, S., & Sutcliffe, A. G. (2012). An overview of drug therapies used in the
treatment of dystonia and spasticity in children. Archives of Disease in Childhood-Education and Practice,
97(6), 230-235.
- 8. Simon, O., & Yelnik, A. (2010). Managing spasticity with drugs. European Journal of Physical and
Rehabilitation Medicine, 46(3), 401-410.
- 9. Koman, L. A., Mooney III, J. F., Smith, B. P., Goodman, A., & Mulvaney, T. (1994). Management of spasticity in
cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial. Journal of
Pediatric Orthopaedics, 14(3), 299-303.
- 10. Novak, I., Morgan, C., Fahey, M., Finch-Edmondson, M., Galea, C., Hines & et al. (2020). State of the
evidence traffic lights 2019: systematic review of interventions for preventing and treating children with
cerebral palsy. Current Neurology and Neuroscience Reports, 20, 1-21.
- 11. Novak, I., Mcintyre, S., Morgan, C., Campbell, L., Dark, L., Morton, N., & et al. (2013). A systematic review of
interventions for children with cerebral palsy: state of the evidence. Developmental Medicine & Child
Neurology, 55(10), 885-910.
- 12. Mathevon, L., Bonan, I., Barnais, J.-L., Boyer, F., & Dinomais, M. (2019). Adjunct therapies to improve
outcomes after botulinum toxin injection in children: A systematic review. Annals of Physical and
Rehabilitation Medicine, 62(4), 283-290.
- 13. Barnes, M. P., & Johnson, G. R. (2001). Upper motor neurone syndrome and spasticity: Clinical
management and neurophysiology: Cambridge University Press.
- 14. Gage, J. R., Schwartz, M. H., Koop, S. E., & Novacheck, T. F. (2009). The identification and treatment of gait
problems in cerebral palsy: John Wiley & Sons.
- 15. Klingels, K., Demeyere, I., Jaspers, E., De Cock, P., Molenaers, G., Boyd, R., & et al. (2012). Upper limb
impairments and their impact on activity measures in children with unilateral cerebral palsy. European
Journal of Paediatric Neurology, 16(5), 475-484.
- 16. Scott, A. B. (1980). Botulinum toxin injection into extraocular muscles as an alternative to strabismus
surgery. Ophthalmology, 87(10), 1044–1049.
- 17. Whurr, R., Lorch, M., Fontana, H., Brookes, G., Lees, A., & Marsden, C. (1993). The use of botulinum toxin in the treatment of adductor spasmodic dysphonia. Journal of Neurology, Neurosurgery & Psychiatry, 56(5),
526-530.
- 18. Aoki, K., & Guyer, B. (2001). Botulinum toxin type A and other botulinum toxin serotypes: a comparative
review of biochemical and pharmacological actions. European Journal of Neurology, 8, 21-29.
- 19. Cosgrove, A., & Graham, H. (1994). Botunum toxin a prevents the development of contractures in the
hereditary spastc mouse. Developmental Medicine & Child Neurology, 36(5), 379-385.
- 20. Kay, R. M., Rethlefsen, S. A., Fern-Buneo, A., Wren, T. A., & Skaggs, D. L. (2004). Botulinum toxin as an
adjunct to serial casting treatment in children with cerebral palsy. The Journal of Bone & Joint Surgery 86(11),
2377-2384.
- 21. Lee, S. J., Sung, I. Y., Jang, D. H., Yi, J. H., Lee, J. H., & Ryu, J. S. (2011). The effect and complication of
botulinum toxin type A injection with serial casting for the treatment of spastic equinus foot. Annals of
Rehabilitation Medicine, 35(3), 344-353.
- 22. Picelli, A., Santamato, A., Chemello, E., Cinone, N., Cisari, C., Gandolfi, M., & et al. (2019). Adjuvant treatments associated with botulinum toxin injection for managing spasticity: An overview of the literature.
Annals of Physical and Rehabilitation Medicine, 62(4), 291-296.
- 23. Valentine, J., Stannage, K., Fabian, V., Ellis, K., Reid, S., & et al. (2016). Muscle histopathology in children with
spastic cerebral palsy receiving botulinum toxin type A. Muscle & Nerve, 53(3), 407-414.
- 24. De Beukelaer, N., Weide, G., Huyghe, E., Vandekerckhove, I., Hanssen, B., Peeters, N. et al. (2022). Reduced
cross-sectional muscle growth six months after botulinum toxin type-A injection in children with spastic
cerebral palsy. Toxins, 14(2), 139.
- 25. Bovend'Eerdt, T. J., Newman, M., Barker, K., Dawes, H., Minelli, C., & Wade, D. T. (2008). The effects of
stretching in spasticity: a systematic review. Archives of Physical Medicine and Rehabilitation, 89(7), 1395-1406.
- 26. Smania, N., Picelli, A., Munari, D., Geroin, C., Ianes, P., Waldner, A., & Gandolfi, M. (2010). Rehabilitation
procedures in the management of spasticity. Eur J Phys Rehabil Med, 46(3), 423-438.
- 27. Mills, P. B., Finlayson, H., Sudol, M., & O’Connor, R. (2016). Systematic review of adjunct therapies to
improve outcomes following botulinum toxin injection for treatment of limb spasticity. Clinical Rehabilitation,
30(6), 537-548.
- 28. Franceschini, M., Iocco, M., Molteni, F., Santamato, A., & Smania, N. (2014). Management of stroke patients
submitted to botulinum toxin type A therapy: a Delphi survey of an Italian expert panel of specialist injectors.
European Journal of Physical and Rehabilitation Medicine, 50(5), 525-533.
- 29. Picelli, A., Smania, N., Storti, I., Munari, D., Fontana, C., Fiaschi, A., & et al. (2011). Immediate versus delayed
electrical stimulation boosts botulinum toxin effect: A pilot study. Movement Disorders, 26(9), 1785-1786.
- 30. Aydil, S., Akpinar, F. M., Akpinar, E., Beng, K., & Yagmurlu, M. F. (2019). Effectiveness of multilevel botulinum
toxin A injection with integrated treatment program on spasticity reduction in non-ambulatory young
children with cerebral palsy. Medical Principles and Practice, 28(4), 309-314.
- 31. Bandholm, T., Jensen, B. R., Nielsen, L. M., Rasmussen, H., Bencke, J., Curtis, D., & et al. (2012).
Neurorehabilitation with versus without resistance training after botulinum toxin treatment in children with
cerebral palsy: A randomized pilot study. NeuroRehabilitation, 30(4), 277-286.
- 32. Lannin, N. A., Novak, I., & Cusick, A. (2007). A systematic review of upper extremity casting for children
and adults with central nervous system motor disorders. Clinical Rehabilitation, 21(11), 963-976.
- 33. Stoeckmann, T. (2001). Casting for the person with spasticity. Topics in Stroke Rehabilitation, 8(1), 27-35.
- 34. Milne, N., Miao, M., & Beattie, E. (2020). The effects of serial casting on lower limb function for children with
Cerebral Palsy: a systematic review with meta-analysis. BMC Pediatrics, 20, 1-23.
- 35. Preissner, K. S. (2002). The effects of serial casting on spasticity: A literature review. Occupational
Therapy in Health Care, 14(2), 99-106.
- 36. Hayek, S., Gershon, A., Wientroub, S., & Yizhar, Z. (2010). The effect of injections of botulinum toxin type A
combined with casting on the equinus gait of children with cerebral palsy. The Journal of Bone & Joint
Surgery British Volume, 92(8), 1152-1159.
- 37. Tedroff, K., Granath, F., Forssberg, H., & Haglund‐Akerlind, Y. (2009). Long‐term effects of botulinum toxin A
in children with cerebral palsy. Developmental Medicine & Child Neurology, 51(2), 120-127.
- 38. Betancourt, J. P., Eleeh, P., Stark, S., & Jain, N. B. (2019). Impact of ankle-foot orthosis on gait efficiency in
ambulatory children with cerebral palsy: a systematic review and meta-analysis. American Journal of
Physical Medicine & Rehabilitation, 98(9), 759-770.
- 39. Fess, E. E. (2002). A history of splinting: to understand the present, view the past. Journal of Hand
Therapy, 15(2), 97-132.
- 40. Garbellini, S., Robert, Y., Randall, M., Elliott, C., & Imms, C. (2018). Rationale for prescription, and
effectiveness of, upper limb orthotic intervention for children with cerebral palsy: a systematic review.
Disability and Rehabilitation, 40(12), 1361-1371.
- 41. Santamato, A., Notarnicola, A., Panza, F., Ranieri, M., Micello, M. F., Manganotti, P., & et al. (2013). SBOTE study: extracorporeal shock wave therapy versus electrical stimulation after botulinum toxin type a injection
for post-stroke spasticity–a prospective randomized trial. Ultrasound in Medicine & Biology, 39(2), 283-291.
- 42. Wu, Y.-T., Chang, C.-N., Chen, Y.-M.,& Hu, G.-C. (2017). Comparison of the effect of focused and radial
extracorporeal shock waves on spastic equinus in patients with stroke: a randomized controlled trial.
European Journal of Physical and Rehabilitation Medicine, 54(4), 518-525.
- 43. Emara, H. A., Al-Johani, A. H., Khaled, O. A., Ragab, W. M., & Al-Shenqiti, A. M. (2022). Effect of
extracorporeal shock wave therapy on spastic equinus foot in children with unilateral cerebral palsy. Journal
of Taibah University Medical Sciences, 17(5), 794-804.
- 44. Vidal, X., Morral, A., Costa, L., & Tur, M. (2011). Radial extracorporeal shock wave therapy (rESWT) in the treatment of spasticity in cerebral palsy: a randomized, placebo-controlled clinical trial. NeuroRehabilitation, 29(4), 413-419.
- 45. Ansari, N., Adelmanesh, F., Naghdi, S., & Tabtabaei, A. (2006). The effect of physiotherapeutic ultrasound
on muscle spasticity in patients with hemiplegia: a pilot study. Electromyography and Clinical
Neurophysiology, 46(4), 247.
- 46. Ansari, N., Naghdi, S., Bagheri, H., & Ghassabi, H. (2007). Therapeutic ultrasound in the treatment of ankle
plantarflexor spasticity in a unilateral stroke population: a randomized, single-blind, placebo-controlled trial.
Electromyography and Clinical Neurophysiology, 47(3), 137.
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