Polikistik over sendromlu infertil kadınlarda glukoz potasyum oranı ile insülin direnci arasındaki ilişkinin araştırılması

Year 2024, , 120 - 126, 29.05.2024

Naziye Gürkan

https://doi.org/10.21673/anadoluklin.1183228

Abstract

Amaç: Bu çalışmanın amacı, polikistik over sendromlu (PKOS) infertil kadınlarda glukoz potasyum (Glu/K+) oranı ile insülin direnci (İR) arasındaki ilişkiyi değerlendirmektir. PKOS’lularda insulin direnci için Glu/K+ oranı gibi yeni bir tanı parametresinin tanımlanması gereklidir.

Yöntemler: Bu retrospektif vaka kontrol çalışmasına üreme çağındaki toplam 198 kadın dahil edildi. PKOS grubunu 20-39 yaş arası infertilite ve PKOS tanısı almış kadınlar oluşturdu. Kontrol grubunu infertilite tanısı almış ancak PKOS olmayan kadınlar oluşturdu.

Bulgular: Katılımcıların yaş ve vücut kitle indeksi sırasıyla 30.31±4.68 ve 26.53±4.80 idi. Açlık kan şekeri PKOS tanısı olanlarda daha yüksek bulundu (p<0.05). İnsülin direnci için homeostatik model değerlendirmesi (HOMA-IR) ve açlık insülini PKOS tanısı olanlarda daha yüksek bulundu (p<0.05). PKOS tanısı olanlarda serum Glu/K+ oranı daha yüksek bulundu (p<0.05). PCOS’lu kadınlarda açlık insülini ile Glu/K+ oranı arasında pozitif bir ilişki bulundu (p<0.05). Glu/K+ oranı için işlem karakteristiği (ROC) eğrisi altında kalan alan insüline yakın 0.719 olarak bulundu.

Sonuç: Sonuçlarımız serum Glu/K+ oranının olumlu olduğunu ve PKOS için tanısal özellikleri olan insüline yakın olduğunu göstermektedir. Serum Glu/K+ oranının PKOS’ta inslin direnci için değerli bir biyobelirteç olabileceğini düşünmekteyiz.

Keywords

Glukoz, insulin rezistansı, potasyum, polikistik over sendromu

Investigation of the relationship between glucose potassium ratio and insulin resistance in polycystic ovary syndrome infertile women

Abstract

Aim: The aim of this study was to evaluate the relationships between glucose potassium (Glu/K+) ratio and insulin resistance (IR) in infertile women with polycystic ovary syndrome (PCOS). It is necessary to identify a new diagnostic parameter such as Glu/K+ ratio for IR in PCOS patients.

Methods: A total of 198 reproductive-aged women were included in this retrospective case–control study. Women aged 20-39 years diagnosed with infertility and PCOS constituted the PCOS group. Women who were diagnosed with infertility but not PCOS formed the control group.

Result: The age and body mass index (BMI) of the participants were 30.31±4.68 and 26.53±4.80, respectively. Fasting blood glucose was found to be higher in those with a diagnosis of PCOS (p<0.05). Homeostatic model assessment for insulin resistance (HOMA-IR) and fasting insulin were found to be higher in those with a diagnosis of PCOS (p<0.05). Serum Glu/K+ ratio was found to be higher in those diagnosed with PCOS (p<0.05). A positive correlation was found between fasting insulin and Glu/K+ ratio in PCOS women (p<0.05). The area under the ROC curve for the Glu/K+ ratio was found to be 0.719, close to the insulin.

Conclusion: Our outcomes indicate that the serum Glu/K+ ratio is favorable and closely related to insulin, which has diagnostic properties for PCOS. We believe the serum Glu/K+ ratio may be a valuable biomarker for insulin resistance in PCOS.

Keywords

Glucose, insulin resistance, polycystic ovary syndrome, potassium

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