Vitamin D Eksikliği ile Endotel Disfonksiyon Göstergelerinden Serum Endocan ve Asymetric Dimetil Arginin (ADMA) Düzeylerı̇ Arasındaki İlişki

Year 2020, , 112 - 119, 13.06.2020

Selin Yurdakul Mustafa Çakırca , Ömer Faruk Özer , İskender Ekinci Elif Ece Doğan Cumali Karatoprak

https://doi.org/10.21673/anadoluklin.626396

Abstract

Giriş: Son zamanlarda D vitamini eksikliğinin kemik metabolizma hastalıkları dışında, alzheimer, parkinson, multiple sklerozis, diyabet, kardiyovasküler hastalıklar gibi pek çok hastalığın oluşmasında rolü olabileceğini destekleyen çalışmalar artmaktadır. Biz de çalışmamızda D vitamini düzeyinin, kardiyovasküler erken risk belirteçleri olarak kabul edilen serum endocan ve ADMA düzeyleri arasındaki ilişkiyi araştırmayı amaçladık.

Materyal- Metod: Çalışmada Vitamin D düzeyi <10 ng/ml olan 42 kişi (grup 1) ve vitamin D düzeyi > 30 ng/ml olan 35 kişiden (grup2) oluşan iki grup oluşturuldu. Grupların VKİ, serum vitamin D, Endocan, ADMA, PTH, TSH, Glikoz, HOMA-IR, HDL kolesterol, LDL kolesterol, Trigliserit, düzeyleri karşılaştırıldı.

Bulgular: Çalışmaya dahil edilen toplam 77 hastanın sonuçları karşılaştırıldı. Her iki grubun yaş, cinsiyet ve BMI değerleri karşılaştırıldığında anlamlı fark olmadığı saptandı (sırasıyla p:0.67, p:0.69, p:0.052). Grup 1 de serum ADMA düzeyi 104.5 ± 44 μmol/L olarak, grup 2’de 90.42 ± 29 μmol/L tespit edildi (p:0.31). Endocan düzeyi ise grup 1’de 549.5 ± 245 ng/L ve grup 2’de 465.99 ± 207 ng/L tespit edildi (p:0.12). Vitamin D düzeyi ile endocan düzeyi arasında anlamlı negatif korelâsyon saptandı (r:-0.26 p:0.02). Serum endocan ve ADMA arasında da anlamlı bir korelâsyon izlenmedi (r:0.19, p:0.1). Gruplar arası PTH, ALT, ALP, HDL kolesterol ve Trigliserit düzeylerinde istatistiksel olarak anlamlı fark tespit edilirken diğer parametrelerde anlamlı olarak fark tespit edilemedi.

Sonuç: Kardiyovasküler riski değerlendirmek üzere endotel disfonksiyonu göstergelerinden serum endocan ve ADMA düzeylerini incelediğimiz çalışmada vitamin D düşüklüğü olan hastalarda anlamlı bir değişim saptamadık. Bu parametreler üzerinden yalnızca vitamin D düşüklüğünün endotel disfonksiyonu üzerine bir etki saptayamadığımızı söyleyebiliriz. Ancak çalışma sınırlı sayıda gönüllü ile yapıldığından daha kesin sonuçlara ulaşmak için daha büyük çalışmalara ihtiyaç olduğunu düşünüyoruz.

Keywords

Vitamin D eksikliği, Endotelial disfonksiyon, ADMA

Supporting Institution

Yok

The relationship between vitamin D deficiency and serum endocan and asymetric dimethylarginine levels, indicators of endothelial dsyfunction

Abstract

Backround: Recently, studies support that the lack of vitamin D deficiency may play a role in the pathogenesis of many diseases such as alzheimer, Parkinson, multiple sclerosis, diabetes mellitus, cardiovascular diseases.

Objectives: We aimed to investigate the relationship between vitamin D levels and serum endocan and ADMA levels, which are accepted as cardiovascular early risk markers, by determining vitamin D levels in patients without known chronic disease history in our study.

Material and Method: According to Vitamin D levels, we divided patients into two groups as; Vitamin D <10 ng/ml (Group 1) ve vitamin D level > 30 ng/ml (Group 2) to investigate. Levels of BMI, serum Vitamin D, Endocan, ADMA of the groups were compared.

Results: The results of a total of 77 patients included in the study were compared. There was no significant difference in age, gender and BMI between the two groups (p: 0.67, p: 0.69, p: 0.052, respectively). Serum ADMA levels were determined as 104.5 ± 44 μmol / L in group 1 and 90.42 ± 29 μmol / L in group 2 (p: 0.31). Endocan levels were 549.5 ± 245 ng / L in group 1 and 465.99 ± 207 ng / L in group 2 (p: 0.12). There was a significant negative correlation between vitamin D levels and endocan levels (r: -0.26 p: 0.02).

Conclusion: In this study which we examined serum endocan and ADMA levels from endothelial dysfunction indicators to assess cardiovascular risk, we did not find a significant change in patients with low vitamin D levels. Based on these parameters, we can say that only vitamin D deficiency has no effect on endothelial dysfunction.

Keywords

Vitamin D deficiency, Endothelial Dysfunction, ADMA

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