Assessing The Relationship Between Clinical Characteristics and Obsessive-Compulsive Disorder Comorbidity and Obsessive-Compulsive Symptoms in Patients With Schizophrenia

Year 2020, , 81 - 87, 13.06.2020

Ahmet Kokurcan

https://doi.org/10.21673/anadoluklin.661854

Abstract

Aim: There is a high prevalence of obsessive-compulsive symptoms (OCS) and obsessive-compulsive disorder (OCD) comorbidity in patients with schizophrenia. Previous studies investigating the OCS/OCD comorbidity in schizophrenia have obtained conflicting results. The aim of this study was to investigate the relationship between OCS/OCD comorbidity, and sociodemographic variables and clinical symptoms in patients with schizophrenia.

Materials and Methods: Two-hundred and eighty patients with schizophrenia who were admitted to the Psychiatry Outpatient Clinic of Dışkapı Training and Research Hospital were included into the study. Brief Psychiatric Rating Scale (BPRS), Positive and Negative Symptoms Rating Scale (SAPS-SANS), Calgary Depression Scale for Schizophrenia (CDSS) and Yale Brown Obsessive Compulsion Scale (YBOCS) were applied to all individuals. Sociodemographic variables and clinical characteristics of patients without OCD, and manifesting subthreshold OCS were compared seperately with characteristics of those with OCD comorbidity. Descriptive tests and Pearson correlation analysis were used for statistical analysis.

Results: OCD comorbidity was associated with higher SANS, SAPS, and BPRS scores in this study (p <0.05). Additionally, IGD scores were lower and CDRS scores were higher in the patients with OCD compared to those without OCD (p <0.05). Severity of the negative and depressive symptoms in patients with subthreshold OCS did not show a significant difference from those with OCD comorbidity (p> 0.05).

Conclusion: The patients with comorbid OCD presented different clinical features and more severe psychotic symptoms compared to those without OCD. In addition, OCD comorbidity was associated with lower functionality, and more severe depressive symptoms in this study. However, there was no significant difference between those with OCS, and OCD in severity of negative and depressive symptoms. Prospective studies are needed to assess the impact of OCS and OCD on clinical features of schizophrenia.

Keywords

schizophrenia, comorbidity, obsessive compulsive disorder

Şizofreni Hastalarında Klinik Semptomların Obsesif Kompülsif Bozukluk Eş Tanısıyla ve Obsesif Kompülsif Semptomlarla İlişkisinin Değerlendirilmesi

Abstract

Amaç: Şizofrenide obsesif kompülsif semptomların (OKS) ve obsesif kompülsif bozukluğun (OKB) görülme sıklığı yüksek olup; şizofrenide OKS/OKB eş tanısının özelliklerini araştıran çalışmalarda çelişkili sonuçlar elde edilmiştir. Bu çalışmada şizofreni hastalarında OKS/OKB eş tanısının sosyodemografik ve klinik özellikler ile ilişkisinin değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntemler: Bu çalışmaya Dışkapı Eğitim ve Araştırma Hastanesi Psikiyatri Polikliniğine başvuran 280 şizofreni hastası dahil edilmiştir. Çalışmaya alınan Pozitif ve Negatif Belirtileri Değerlendirme Ölçeği (SAPS-SANS), Calgary Şizofrenide Depresyon Ölçeği (CŞDÖ) ve Yale Brown Obsesyon Kompülsiyon Ölçeği (YBOKÖ) uygulanmıştır. OKB eş tanısı olmayan hastalar ve eşik altı OKS bulunan hastaların klinik özellikleri ayrı olarak OKB eş tanılı hastaların özellikleriyle karşılaştırılmıştır. İstatistiksel analiz için tanımlayıcı testler ve Pearson korelasyon analizi kullanılmıştır.

Bulgular: OKB eş tanısı olan hastaların SANS, SAPS ve KPDÖ puanları eş tanısı olmayan hastalardan daha yüksek bulunmuştur (p< 0.05). Ayrıca, OKB eş tanılı hastalarda eş tanı bulunmayan hastalara göre daha düşük İGD puanı ile daha yüksek CŞDÖ puanı saptanmıştır (p< 0.05). OKB eşik altı semptomları bulunan hastaların klinik özellikleri SANS ve CŞDÖ puanları OKB eş tanısı bulunan hastalardan istatiksel farklılık göstermemiştir (p> 0.05).

Sonuç: OKB eş tanısı bulunan ve bulunmayan hastaların klinik özellikleri arasında önemli farklılıklar olduğu görülmüştür. OKB eş tanısında pozitif, negatif ve depresif semptom şiddeti daha yüksek işlevsellik ise daha düşük bulunmuştur. Bununla beraber, eşik altı OKS olan hastalar ile OKB eş tanılı hastaların negatif ve depresif belirti şiddetleri arasında anlamlı bir farklılık görülmemiştir. Şizofrenide OKS ve OKB eş tanısının klinik öneminin daha iyi anlaşılabilmesi için prospektif çalışmalara ihtiyaç duyulmaktadır.

Keywords

şizofreni, eş tanı, obsesif kompülsif bozukluk

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