Clinical Features and Treatment Results of Metastatic Breast Cancer Patients: A Single Center Experience

Year 2020, Volume: 25 Issue: 2, 75 - 80, 13.06.2020

Mahmut Büyükşimşek Semra Paydaş Servet Başdoğan Mustafa Toğun Abdullah Evren Yetişir Cem Mirili Ali Oğul Mert Tohumcuoğlu

https://doi.org/10.21673/anadoluklin.641856

Abstract

Aim: Breast
cancer is the most common cancer that causes death in women. We wanted to investigate
the clinical features and treatment results of patients with metastatic breast
cancer.

Materials and Methods:
Sixty-five patients with metastatic breast cancer followed in the Oncology
Department of Cukurova University between 2011 and 2017 were included in the
study. The clinical features and treatments of the patients were investigated
retrospectively.

Results: The
majority of patients had only bone metastases. Re-biopsy was performed in 66,6%
of 45 patients who subsequently underwent metastatic stage; and tumor biology
had changed in 20% of these patients. The progression-free
survival in the metastatic stage was 10 months and the overall survival was 34
months.

Discussion and Conclusion:
Survival
of patients with metastatic breast cancer is consistent with the literature.
When new agents and new therapies are also taken into consideration, re-biopsy
at relapses is critical in considering the possibility of changes in disease
biology.

Keywords

metastatic breast cancer, survival results, chemotherapy, targeted treatments

Metastatik Meme Kanserli Hastaların Klinik Özellikleri ve Tedavi Sonuçları: Tek Merkez Deneyimi

Abstract

Amaç:
Meme kanseri
kadınlarda en sık görülen ve en sık ölüme neden olan kanserdir. Biz
de merkezimizde takip ettiğimiz metastatik meme kanseri (MMK) olan hastaların klinik
özelliklerini ve tedavi sonuçlarını araştırmak istedik.

Gereç
ve Yöntemler: Çukurova
Üniversitesi Onkoloji bilim dalında 2011-2017 yılları arasında takip edilen 65 MMK
olan hasta çalışmaya dahil edildi. Hastaların klinik özellikleri ve aldıkları
tedaviler retrospektif olarak araştırıldı.

Bulgular:
Hastaların büyük
çoğunluğunda sadece kemik metastazı vardı. Sonradan metastatik evreye geçen 45
hastanın %66,6’ sına yeniden biyopsi yapıldı; bu hastaların %20’ sinde tümör
biyolojisi değişmişti. Metastatik evrede progresyonsuz sağkalım 10 ay, ortalama
sağkalım 34 ay olarak hesaplandı.

Tartışma ve Sonuç: MMK
olan hastalarda literatürle uyumlu sağkalımlar elde edilmiştir. Yeni kullanıma
giren ajanlar ve hedefleyici tedavilerdeki gelişmeler de göz önüne alındığında
hastalık biyolojisindeki değişme ihtimali göz önünde bulundurularak relapslarda
yeniden biyopsi yapılması kritik önemdedir.

Keywords

metastatik meme kanseri, sağkalım sonuçları, kemoterapi, hedefleyici tedaviler

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