The role of the laboratory in the diagnosis of newborn sepsis through the eyes of a microbiologist

Year 2022, Volume: 27 Issue: 2, 227 - 242, 24.05.2022

Nazife Akman Pınar Sağıroğlu

https://doi.org/10.21673/anadoluklin.975177

Abstract

Sepsis remains the leading cause of morbidity and mortality in the newborn population. Unfortunately, current definitions of sepsis in pediatrics do not address sepsis in the premature
population. Many neonatal research publications have criteria for the definition of sepsis, but they vary widely, and there is typically a heavy emphasis on microbiological culture. Accurate identification and screening of sepsis are essential for clinical management, healthcare design, and future research. In this review, the definition and classification of neonatal sepsis, causative bacterial pathogens, antimicrobial resistance, epidemiology, biomarkers used in diagnostic methods, and current information are shared.

Keywords

antibiotic resistance, biomarker;, blood culture, neonatal sepsis

Mikrobiyolog gözüyle yenidoğan sepsisinin tanısında laboratuvarın rolü

Abstract

Sepsis, yenidoğan popülasyonunda önde gelen morbidite ve mortalite nedeni olmaya devam etmektedir. Pediatride mevcut sepsis tanımları, prematüre popülasyondaki sepsisi ele almamaktadır. Birçok yenidoğan araştırma yayınlarında sepsis tanımı için kriterler vardır, ancak bunlar büyük ölçüde farklılık gösterir ve tipik olarak mikrobiyolojik kültüre yoğun bir vurgu bulunmaktadır. Sepsisin doğru tanımlanması ve taranması, klinik yönetim, sağlık hizmeti tasarımı ve gelecekteki araştırmalar için önemlidir. Bu derlemede neonatal sepsisin tanımı, sınıflaması, etken bakteriyel patojenleri, antimikrobiyal direnci, epidemiyolojisi, tanı yöntemlerinde kullanılan biyobelirteçler ve güncel bilgiler paylaşılmıştır.

Keywords

antibiyotik direnci, biyobelirteç;, kan kültürü, neonatal sepsis

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