Can inflammatory markers such as lymphocyte to C-reactive protein ratio and hemoglobin, albumin, lymphocyte, and platelet score predict complications after loop ileostomy closure?

Year 2024, Volume: 29 Issue: 2, 224 - 232, 29.05.2024

Mevlüt Yordanagil Hüseyin Bakır Murat Yıldırım Namık Özkan İsmail Okan

https://doi.org/10.21673/anadoluklin.1421211

Abstract

Aim: This study aims to investigate whether inflammatory biochemical markers such as hemoglobin, albumin, lymphocyte, platelet scores (HALP), and lymphocyte-C-reactive protein ratio (LCR) can predict complications after ileostomy closure.

Methods: Eighty-five patients who underwent loop ileostomy closure were included in this retrospective study. Alongside the patient’s demographic data, surgical data, histopathology results, and biochemistry data were recorded. Complications that occurred within the first 30 days after surgery were evaluated using the Clavien-Dindo classification. Inflammation markers such as HALP and LCR were obtained using biochemical parameters.

Results: The rate of mild complications (Clavien-Dindo I and II) was 27%, while the rate of severe complications (Clavien-Dindo III and IV) was 12.94%. A statistically significant correlation was found between the development of early complications and levels of albumin, lymphocyte, neutrophil, and C-reactive protein (CRP) (p<0.05). Patients who developed complications had lower mean serum albumin levels and higher mean neutrophil and CRP values. There was a strong correlation between HALP score and LCR and complications in patients (p<0.05).

Conclusion: It was concluded that HALP and LCR measured preoperatively could be important predictors of early complications after loop ileostomy closure.

Keywords

Biochemical markers, inflammation, loop ileostomy, postoperative complications

Lenfosit/C-reaktif protein oranı ve hemoglobin, albümin, lenfosit ve trombosit skoru gibi enflamatuar belirteçler loop ileostomi kapatılması sonrası komplikasyonları öngörebilir mi?

Abstract

Amaç: Bu çalışmanın amacı hemoglobin, albümin, lenfosit ve trombosit skorları (HALP) ve lenfosit-C-reaktif protein oranı (LCR) gibi inflamatuar biyokimyasal belirteçlerin ileostomi kapatılması sonrası komplikasyonları öngörüp öngöremediğini araştırmaktır.

Yöntemler: Bu retrospektif çalışmaya loop ileostomi kapatılan seksen beş hasta dahil edildi. Hastaların demografik verilerinin yanı sıra ameliyat verileri, histopatoloji sonuçları ve biyokimya verileri veritabanına kaydedildi. Ameliyattan sonraki ilk 30 gün içinde ortaya çıkan komplikasyonlar Clavien-Dindo sınıflandırması kullanılarak değerlendirildi. HALP ve LCR gibi inflamasyon belirteçleri biyokimyasal parametreler kullanılarak elde edildi.

Bulgular: Hafif komplikasyonların (Clavien-Dindo I ve II) oranı %27 iken, ciddi komplikasyonların (Clavien-Dindo III ve IV) oranı %12.94 idi. Erken komplikasyon gelişimi ile albümin, lenfosit, nötrofil ve C-reaktif protein (CRP) düzeyleri arasında istatistiksel olarak anlamlı bir korelasyon bulundu (p<0.05). Komplikasyon gelişen hastaların ortalama serum albümin düzeyleri daha düşük, ortalama nötrofil ve CRP değerleri ise daha yüksekti. HALP skoru ve LCR ile hastalardaki komplikasyonlar arasında güçlü bir korelasyon vardı (p<0.05).

Sonuç: Ameliyat öncesi ölçülen HALP ve LCR’nin loop ileostomi kapatılması sonrası erken komplikasyonların önemli belirleyicileri olabileceği sonucuna varıldı.

Keywords

Ameliyat sonrası komplikasyonlar, biyokimyasal belirteçler, inflamasyon, loop ileostomi

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