Review
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PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ

Year 2024, Volume: 3 Issue: 2, 197 - 209, 03.12.2024
https://doi.org/10.70756/anameud.1560690

Abstract

Punicacea familyasına ait meyve türlerinden biri olan nar (Punica granatum Linn.), tropik ve subtropik iklim kuşağında yetişen ve biyoaktif bileşenler bakımından zengin bir meyvedir. Narın işlenmesi sonrası oluşan atık ürünler arasında nar kabuğu ve nar çekirdeği posası yer almaktadır. Narın tüketimi sonrası oluşan atık miktarı fazla olduğu için nar atıklarının besleyici ve biyoaktif bileşenlerini değerlendirmek, israfı önlemek ve çevreyi korumak adına yapılan çalışma sayısı artmaktadır. Nar meyvesinin içeriğinde fenolik bileşikler, vitamin, mineral, organik asitler, antosiyaninler gibi birçok biyoaktif bileşen bulunmaktadır. Nar çekirdeği yağındaki ana yağ asidi punisik asittir. Yapılan in vitro ve in vivo hayvan çalışmalarının sonuçlarına göre punisik asidin antiinflamatuar, antidiyabetik, antikanserojenik, antioksidan gibi birçok sağlık etkisi bulunmaktadır. Bu derlemede punisik asidin sağlık üzerindeki olası etkilerini açıklamak amaçlanmaktadır.

Ethical Statement

Derleme makale türündedir

Supporting Institution

Bulunmamaktadır

References

  • Abbasi̇, H., Rezaei̇, K., Emam-Djomeh, Z., & Mousavi̇, M. (2008). Effect of various extraction conditions on the phenolic contents of pomegranate seed oil. European Journal of Li̇pi̇d Sci̇ence Technology, 110(5), 435-440.
  • Anusree, S. S., Nisha, V. M., Priyanka, A., & Raghu, K. G. (2015). Insulin resistance by TNF‐α is associated with mitochondrial dysfunction in 3T3‐L1 adipocytes and is ameliorated by punicic acid, a PPARγ agonist. Molecular and Cellular Endocrinology, 413(2015), 120–128.
  • Arao, K., Wang, Y., Inoue, N., Hi̇rata, J., Cha, J., Nagao, K., & Yanagita, T. (2004). Dietary effect of pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic oletf rats. Li̇pi̇ds İn Health And Di̇sease, 3, 24-31.
  • Aruna, P., Venkataramanamma, D., Si̇ngh, A. K., & Singh, R.P. (2016). Health benefits of punicic acid: a review. Comprehensive Reviews in Food Science and Food Safety, 15(1), 16-27.
  • Aydemir, B., & Karadağ Sarı, E. (2009). Antioksidanlar ve büyüme faktörleri ile ilişkisi. Kocatepe Veteriner Dergisi, 2(2), 56-60.
  • Boussetta, T., Raad, H., Lettéron, P., Gougerot-Poci̇dalo, M., Mari̇e, J., Dri̇ss, F., & El-Benna, J. (2009). Punicic acid a conjugated linolenic acid ınhibits tnfα-ınduced neutrophil hyperactivation and protects from experimental colon ınflammation in rats. Plos One, 4(7), e6458.
  • Bozkurt, T., & Ergün, Z. (2021). Fatty acid composition and antioxidant capacity of pomegranate seed oil. GSC Biological and Pharmaceutical Sciences, 15(2), 103-110.
  • Cao, Y., Gao, H., Chen, J., Chen, Z., & Yang, L. (2006). Identification and characterization of conjugated linolenic acid isomers by ag+-hplc and nmr. Journal Of Agri̇cultural And Food Chemi̇stry. 54(24), 9004–9009.
  • Costa, A.M. M., Si̇lva, L.D.O., & Torres, A.G. (2019). Chemical composition of commercial cold-pressed pomegranate (punica granatum) seed oil from turkey and ısrael, and the use of bioactive compounds for samples’ origin preliminary discrimination. Journal of Food Composi̇ti̇on and Analysi̇s, 75, 8-16.
  • Costantani, S., Rusolo, F., De Vito, V., Moccia, S., Picariello, G., Capone, F., ... & Volpe, M.G. 2014. Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punica granatum L.) seed oil on breast cancer cell lines. Molecules 19(6): 8644–60.
  • Coursodon-Boyi̇ddle, C. F., Snarrenberg, C.L., Adki̇ns-Ri̇eck, C.K., Bassaganya-Ri̇era, J., Honteci̇llas, R., Lawrence, P., ... & Dvorak, B. (2012). Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis. Ameri̇can Journal Of Physi̇ology-Gastroi̇ntesti̇nal And Li̇ver Physi̇ology, 303(6), 744-751.
  • Çam, M. (2009). Basınçlı solvent ekstraktörü kullanılarak nar kabuğu ve çekirdeğinin antioksidan bileşiklerin su ile ekstraksiyonu (Doktora tezi). YÖK tez merkezinden edinilmiştir (256799).
  • Çam, M., Erdoğan, F., Aslan, D., & Di̇nç, M. (2013). Enrichment of functional properties of ice cream with pomegranate by-products. Journal of Food Sci̇ence, 78(10), 1543-1550.
  • de Melo I.L.P., de Oliveira e Silva A.M., de Carvalho E.B., Yoshime L.T., JAG S., & Mancini-Filho J. Incorporation and effects of punicic acid on muscle and adipose tissues of rats. Lipids Health Dis. 2016;15:1.
  • Di̇mou, C., & Kouteli̇daki̇s, A.E. (2017). A from pomegranate processing by-products to ınnovative value added func-tional ıngredients and bio-based products with several applications in food secto. Baoj Bi̇otech, 3, 210.
  • Ei̇kani̇, M.H., Golmohammad, F., & Homami̇, S.S. (2012). Extraction of pomegranate ( punica granatum l.) seed oil using superheated hexane. Food And Bi̇oproducts Processi̇ng, 90, 32-36.
  • Fa, M., Diana, A., Carta, G., Cordeddu, L., Melis, M., Murru, E., … & Banni, S. Incorporation and Metabolism of C9,T11 and T10,C12 Conjugated Linoleic Acid (CLA) Isomers in Rat Brain. Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids 2005, 1736, 61–66.
  • Fernandes, L., Perei̇ra, J.A., Lopéz-Cortés, İ., Salazar, D.M., Ramalhosa, E., & Casal, S. (2015). Lipid composition of seed oils of different pomegranate (punica granatum l.) cultivars from spain. İnternati̇onal Journal of Food Studi̇es, 4(1), 95-103.
  • Harzallah, A., Hammami, M., Kępczyńska, M. A., Hislop, D. C., Arch, J. R. S., Cawthorne, M. A., & Zaibi, M. S. (2016). Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high‐fat and high‐sucrose diet‐induced obesity mice model. Archives of Physiology and Biochemistry, 122(2), 75–87.
  • Karadeniz, F.., Burdurlu, H.S., Koca, N., & Soyer, Y. (2005). Antioxidant activity of selected fruits and vegetables grown in Turkey. Turkish Journal of Agriculture & Foresty, 29, 297-303.
  • Kaur, C., & Kapoor, H.C. (2002). Antioxidant activity and total phenolic content of some Asian vegetables. International Journal of Food Science and Technology, 37, 153-161.
  • Khajebi̇shak, Y., Payahoo, L., Ali̇vand, M., & Ali̇pour B. (2019). Punicic acid: a potential compound of pomegranate seed oil in type 2 diabetes mellitus management. Journal Cell Physi̇ol, 234(3), 2112-2120.
  • Ki̇ralan, M., Gölükcü, M., & Tokgöz, H. (2009). Oil and conjugated linolenic acid contents of seeds from important pomegranate cultivars (punica granatum l.) grown in turkey. Journal Of The Ameri̇can Oi̇l Chemi̇sts' Soci̇ety, 86(10), 985-990.
  • Ko, K., Dadmohammadi̇, Y., & Abbaspourrad, A. (2021). Nutritional and bioactive components of pomegranate waste used in food and cosmetic applications: a review. Foods, 10(3), 657.
  • Kohno, H., Suzuki̇, R., Yasui̇, Y., Hosokawa, M., Mi̇yashi̇ta, K., & Tanaka, T. (2004). Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci̇ence, 95(6), 481-486.
  • Lansky, E.P., Harrison, G., Froom, P., Jiang, W. (2005a). Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. Investig New Drugs 23:121–2.
  • Lieber, C. (2019). Vox. A Scientist on the Myth of Ugly Produce and Food Waste. https://www.vox.com/thegoods/ 2019/2/26/18240399/food-waste-ugly-produce-myths-farms adresinden edinilmiştir.
  • Mahesar, S. A., Kori, A. H., Sherazi, S. T. H., Kandhro, A. A., & Laghari, Z. H. (2019). Pomegranate seed oil. In M. F. Ramadan (Ed.), Fruit Oils: Chemistry and Functionality, 691–709.
  • Mele, M.C., Cannelli, G., Carta, G., Cordeddu, L., Melis, M.P., Murru, E., … & Banni, S. Metabolism of C9,T11-Conjugated Linoleic Acid (CLA) in Humans. Prostaglandins Leukot. Essent. Fat. Acids 2013, 89, 115–119.
  • Melo, İ.L.P.D., Carvalho, E., & Fi̇lho, J.M. (2014). Pomegranate seed oil (punica granatum l.): a source of punisic acid (conjugated α-linolenic acid). Journal of Human Nutrition and Food Sci̇ence, 2(1), 1021-34.
  • Mollazadeh, H., Sadeghnia, H. R., Hoseini, A., Farzadnia, M., & Boroushaki, M. T. (2016). Effects of pomegranate seed oil on oxidative stress markers, serum biochemical parameters and pathological findings in kidney and heart of streptozotocin‐induced diabetic rats. Renal Failure, 38(8), 1256–1266.
  • Mphahlele, R., Fawole, O., Mokwena, L., & Opara, U.L. (2016). Effect of extraction method on chemical, volatile composition and antioxidant properties of pomegranate juice. South Afri̇can Journal Of Botany, 103, 135-144.
  • Nemer, K. (2009). The role of punicic acid (c9t11c13‐CLNA) in lipid and energy metabolism of mice. The Ohio State University.
  • Özmert Ergin, S. (2019). Nar meyvesi (punica granatum l.) ile farklı nar ürünlerinin antioksidan özellikleri. Akademi̇k Gıda, 17(2), 243-251.
  • Paul, A., & Radhakri̇shnan, M (2020). Pomegranate seed oil in food industry: extraction, characterization, and applications. . Trends in Food Sci̇ence& Technology, 105, 273–283.
  • Pereira de Melo, I.L., de Oliveira e Silva, A.M., Yoshime, L.T., Gasparotto Sattler, J.A., Teixeira de Carvalho, E.B., Mancini-Filho, J. Punicic Acid Was Metabolised and Incorporated in the Form of Conjugated Linoleic Acid in Different Rat Tissues. Int. J. Food Sci. Nutr. 2019, 70, 421–431.
  • Sezgi̇n, A.C., & Arti̇k, N. (2017). The fatty acid composition of pomegranates grown in turkey. İnternati̇onal Journal of Bi̇oprocess & Bi̇otechnologi̇cal Advancements, 2(1), 81-87.
  • Shabbir, M. A., Khan, M. R., Saeed, M., Pasha, I., Khalil, A. A., & Siraj, N. (2017). Punicic acid: A striking health substance to combat metabolic syndromes in humans. Lipids in Health and Disease, 16(1).
  • Tanaka, T., Hosokawa, M., Yasui̇, Y., Ishi̇gamori̇, R., & Mi̇yashi̇ta, A.K. (2011). Cancer chemopreventive ability of conjugated linolenic acids. İnternationaş Journal of Molecular Sci̇ences, 12(11), 7495-7509.
  • Tsuzuki, T., Tokuyama, Y., Igarashi, M., Nakagawa, K., Ohsaki, Y., Komai, M., & Miyazawa, T. (2004). α-Eleostearic Acid (9Z11E13E-18:3) Is Quickly Converted to Conjugated Linoleic Acid (9Z11E-18:2) in Rats. The Journal of Nutrition, 134(10), 2634–2639.
  • Turfan, Ö. (2008). Nar suyu konsantresi üretim ve depolama sürecinde antosiyaninlerdeki değişimler (Yüksek lisans tezi). YÖK tez merkezinden edinilmiştir (233180).
  • Verardo, V., Garci̇a-Salas, P., Baldi̇, E., Segura-Carretero, A., Fernandez-Guti̇errez, A., & Caboni̇, M.F. (2014). Pomegranate seeds as a source of nutraceutical oil naturally rich in bioactive lipids. Food Research İnternati̇onal, 65, 445-452.
  • Vi̇uda-Martos, M., Fernández-López, J., & Pérez-Álvarez, J.A. (2010). Pomegranate and its many functional components as related to human health: a review. Comprehensive Reviews in Food Sci̇ence and Food Safety, 9(6), 635-654.
  • Yamasaki̇, M., Ki̇tagawa, T., Koyanagi̇, N., Chujo, H., Maeda, H., Kohno-Murase, J., ... & Yamada, K. (2006). Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice. Nutri̇ti̇on, 22(1), 54-59.

PUNICIC ACID AND ITS POTENTIAL HEALTH EFFECTS

Year 2024, Volume: 3 Issue: 2, 197 - 209, 03.12.2024
https://doi.org/10.70756/anameud.1560690

Abstract

The pomegranate (Punica granatum Linn.), a fruit belonging to the Punicaceae family, is a fruit grown in tropical and subtropical climates and is rich in bioactive compounds. Among the waste products generated after processing pomegranate, there are pomegranate peel and pomegranate seed pulp. Since the amount of waste generated after pomegranate consumption is high, the number of studies aimed at evaluating the nutritional and bioactive components of pomegranate waste to prevent waste and protect the environment is increasing. Pomegranate fruit contains many bioactive compounds, such as phenolic compounds, vitamins, minerals, organic acids, and anthocyanins. The main fatty acid in pomegranate seed oil is punicic acid. According to the results of in vitro and in vivo animal studies, punicic acid has many health effects, including anti-inflammatory, anti-diabetic, anti-cancer, and antioxidant properties. This review aims to explain the potential effects of punicic acid on health.

References

  • Abbasi̇, H., Rezaei̇, K., Emam-Djomeh, Z., & Mousavi̇, M. (2008). Effect of various extraction conditions on the phenolic contents of pomegranate seed oil. European Journal of Li̇pi̇d Sci̇ence Technology, 110(5), 435-440.
  • Anusree, S. S., Nisha, V. M., Priyanka, A., & Raghu, K. G. (2015). Insulin resistance by TNF‐α is associated with mitochondrial dysfunction in 3T3‐L1 adipocytes and is ameliorated by punicic acid, a PPARγ agonist. Molecular and Cellular Endocrinology, 413(2015), 120–128.
  • Arao, K., Wang, Y., Inoue, N., Hi̇rata, J., Cha, J., Nagao, K., & Yanagita, T. (2004). Dietary effect of pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic oletf rats. Li̇pi̇ds İn Health And Di̇sease, 3, 24-31.
  • Aruna, P., Venkataramanamma, D., Si̇ngh, A. K., & Singh, R.P. (2016). Health benefits of punicic acid: a review. Comprehensive Reviews in Food Science and Food Safety, 15(1), 16-27.
  • Aydemir, B., & Karadağ Sarı, E. (2009). Antioksidanlar ve büyüme faktörleri ile ilişkisi. Kocatepe Veteriner Dergisi, 2(2), 56-60.
  • Boussetta, T., Raad, H., Lettéron, P., Gougerot-Poci̇dalo, M., Mari̇e, J., Dri̇ss, F., & El-Benna, J. (2009). Punicic acid a conjugated linolenic acid ınhibits tnfα-ınduced neutrophil hyperactivation and protects from experimental colon ınflammation in rats. Plos One, 4(7), e6458.
  • Bozkurt, T., & Ergün, Z. (2021). Fatty acid composition and antioxidant capacity of pomegranate seed oil. GSC Biological and Pharmaceutical Sciences, 15(2), 103-110.
  • Cao, Y., Gao, H., Chen, J., Chen, Z., & Yang, L. (2006). Identification and characterization of conjugated linolenic acid isomers by ag+-hplc and nmr. Journal Of Agri̇cultural And Food Chemi̇stry. 54(24), 9004–9009.
  • Costa, A.M. M., Si̇lva, L.D.O., & Torres, A.G. (2019). Chemical composition of commercial cold-pressed pomegranate (punica granatum) seed oil from turkey and ısrael, and the use of bioactive compounds for samples’ origin preliminary discrimination. Journal of Food Composi̇ti̇on and Analysi̇s, 75, 8-16.
  • Costantani, S., Rusolo, F., De Vito, V., Moccia, S., Picariello, G., Capone, F., ... & Volpe, M.G. 2014. Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punica granatum L.) seed oil on breast cancer cell lines. Molecules 19(6): 8644–60.
  • Coursodon-Boyi̇ddle, C. F., Snarrenberg, C.L., Adki̇ns-Ri̇eck, C.K., Bassaganya-Ri̇era, J., Honteci̇llas, R., Lawrence, P., ... & Dvorak, B. (2012). Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis. Ameri̇can Journal Of Physi̇ology-Gastroi̇ntesti̇nal And Li̇ver Physi̇ology, 303(6), 744-751.
  • Çam, M. (2009). Basınçlı solvent ekstraktörü kullanılarak nar kabuğu ve çekirdeğinin antioksidan bileşiklerin su ile ekstraksiyonu (Doktora tezi). YÖK tez merkezinden edinilmiştir (256799).
  • Çam, M., Erdoğan, F., Aslan, D., & Di̇nç, M. (2013). Enrichment of functional properties of ice cream with pomegranate by-products. Journal of Food Sci̇ence, 78(10), 1543-1550.
  • de Melo I.L.P., de Oliveira e Silva A.M., de Carvalho E.B., Yoshime L.T., JAG S., & Mancini-Filho J. Incorporation and effects of punicic acid on muscle and adipose tissues of rats. Lipids Health Dis. 2016;15:1.
  • Di̇mou, C., & Kouteli̇daki̇s, A.E. (2017). A from pomegranate processing by-products to ınnovative value added func-tional ıngredients and bio-based products with several applications in food secto. Baoj Bi̇otech, 3, 210.
  • Ei̇kani̇, M.H., Golmohammad, F., & Homami̇, S.S. (2012). Extraction of pomegranate ( punica granatum l.) seed oil using superheated hexane. Food And Bi̇oproducts Processi̇ng, 90, 32-36.
  • Fa, M., Diana, A., Carta, G., Cordeddu, L., Melis, M., Murru, E., … & Banni, S. Incorporation and Metabolism of C9,T11 and T10,C12 Conjugated Linoleic Acid (CLA) Isomers in Rat Brain. Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids 2005, 1736, 61–66.
  • Fernandes, L., Perei̇ra, J.A., Lopéz-Cortés, İ., Salazar, D.M., Ramalhosa, E., & Casal, S. (2015). Lipid composition of seed oils of different pomegranate (punica granatum l.) cultivars from spain. İnternati̇onal Journal of Food Studi̇es, 4(1), 95-103.
  • Harzallah, A., Hammami, M., Kępczyńska, M. A., Hislop, D. C., Arch, J. R. S., Cawthorne, M. A., & Zaibi, M. S. (2016). Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high‐fat and high‐sucrose diet‐induced obesity mice model. Archives of Physiology and Biochemistry, 122(2), 75–87.
  • Karadeniz, F.., Burdurlu, H.S., Koca, N., & Soyer, Y. (2005). Antioxidant activity of selected fruits and vegetables grown in Turkey. Turkish Journal of Agriculture & Foresty, 29, 297-303.
  • Kaur, C., & Kapoor, H.C. (2002). Antioxidant activity and total phenolic content of some Asian vegetables. International Journal of Food Science and Technology, 37, 153-161.
  • Khajebi̇shak, Y., Payahoo, L., Ali̇vand, M., & Ali̇pour B. (2019). Punicic acid: a potential compound of pomegranate seed oil in type 2 diabetes mellitus management. Journal Cell Physi̇ol, 234(3), 2112-2120.
  • Ki̇ralan, M., Gölükcü, M., & Tokgöz, H. (2009). Oil and conjugated linolenic acid contents of seeds from important pomegranate cultivars (punica granatum l.) grown in turkey. Journal Of The Ameri̇can Oi̇l Chemi̇sts' Soci̇ety, 86(10), 985-990.
  • Ko, K., Dadmohammadi̇, Y., & Abbaspourrad, A. (2021). Nutritional and bioactive components of pomegranate waste used in food and cosmetic applications: a review. Foods, 10(3), 657.
  • Kohno, H., Suzuki̇, R., Yasui̇, Y., Hosokawa, M., Mi̇yashi̇ta, K., & Tanaka, T. (2004). Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci̇ence, 95(6), 481-486.
  • Lansky, E.P., Harrison, G., Froom, P., Jiang, W. (2005a). Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. Investig New Drugs 23:121–2.
  • Lieber, C. (2019). Vox. A Scientist on the Myth of Ugly Produce and Food Waste. https://www.vox.com/thegoods/ 2019/2/26/18240399/food-waste-ugly-produce-myths-farms adresinden edinilmiştir.
  • Mahesar, S. A., Kori, A. H., Sherazi, S. T. H., Kandhro, A. A., & Laghari, Z. H. (2019). Pomegranate seed oil. In M. F. Ramadan (Ed.), Fruit Oils: Chemistry and Functionality, 691–709.
  • Mele, M.C., Cannelli, G., Carta, G., Cordeddu, L., Melis, M.P., Murru, E., … & Banni, S. Metabolism of C9,T11-Conjugated Linoleic Acid (CLA) in Humans. Prostaglandins Leukot. Essent. Fat. Acids 2013, 89, 115–119.
  • Melo, İ.L.P.D., Carvalho, E., & Fi̇lho, J.M. (2014). Pomegranate seed oil (punica granatum l.): a source of punisic acid (conjugated α-linolenic acid). Journal of Human Nutrition and Food Sci̇ence, 2(1), 1021-34.
  • Mollazadeh, H., Sadeghnia, H. R., Hoseini, A., Farzadnia, M., & Boroushaki, M. T. (2016). Effects of pomegranate seed oil on oxidative stress markers, serum biochemical parameters and pathological findings in kidney and heart of streptozotocin‐induced diabetic rats. Renal Failure, 38(8), 1256–1266.
  • Mphahlele, R., Fawole, O., Mokwena, L., & Opara, U.L. (2016). Effect of extraction method on chemical, volatile composition and antioxidant properties of pomegranate juice. South Afri̇can Journal Of Botany, 103, 135-144.
  • Nemer, K. (2009). The role of punicic acid (c9t11c13‐CLNA) in lipid and energy metabolism of mice. The Ohio State University.
  • Özmert Ergin, S. (2019). Nar meyvesi (punica granatum l.) ile farklı nar ürünlerinin antioksidan özellikleri. Akademi̇k Gıda, 17(2), 243-251.
  • Paul, A., & Radhakri̇shnan, M (2020). Pomegranate seed oil in food industry: extraction, characterization, and applications. . Trends in Food Sci̇ence& Technology, 105, 273–283.
  • Pereira de Melo, I.L., de Oliveira e Silva, A.M., Yoshime, L.T., Gasparotto Sattler, J.A., Teixeira de Carvalho, E.B., Mancini-Filho, J. Punicic Acid Was Metabolised and Incorporated in the Form of Conjugated Linoleic Acid in Different Rat Tissues. Int. J. Food Sci. Nutr. 2019, 70, 421–431.
  • Sezgi̇n, A.C., & Arti̇k, N. (2017). The fatty acid composition of pomegranates grown in turkey. İnternati̇onal Journal of Bi̇oprocess & Bi̇otechnologi̇cal Advancements, 2(1), 81-87.
  • Shabbir, M. A., Khan, M. R., Saeed, M., Pasha, I., Khalil, A. A., & Siraj, N. (2017). Punicic acid: A striking health substance to combat metabolic syndromes in humans. Lipids in Health and Disease, 16(1).
  • Tanaka, T., Hosokawa, M., Yasui̇, Y., Ishi̇gamori̇, R., & Mi̇yashi̇ta, A.K. (2011). Cancer chemopreventive ability of conjugated linolenic acids. İnternationaş Journal of Molecular Sci̇ences, 12(11), 7495-7509.
  • Tsuzuki, T., Tokuyama, Y., Igarashi, M., Nakagawa, K., Ohsaki, Y., Komai, M., & Miyazawa, T. (2004). α-Eleostearic Acid (9Z11E13E-18:3) Is Quickly Converted to Conjugated Linoleic Acid (9Z11E-18:2) in Rats. The Journal of Nutrition, 134(10), 2634–2639.
  • Turfan, Ö. (2008). Nar suyu konsantresi üretim ve depolama sürecinde antosiyaninlerdeki değişimler (Yüksek lisans tezi). YÖK tez merkezinden edinilmiştir (233180).
  • Verardo, V., Garci̇a-Salas, P., Baldi̇, E., Segura-Carretero, A., Fernandez-Guti̇errez, A., & Caboni̇, M.F. (2014). Pomegranate seeds as a source of nutraceutical oil naturally rich in bioactive lipids. Food Research İnternati̇onal, 65, 445-452.
  • Vi̇uda-Martos, M., Fernández-López, J., & Pérez-Álvarez, J.A. (2010). Pomegranate and its many functional components as related to human health: a review. Comprehensive Reviews in Food Sci̇ence and Food Safety, 9(6), 635-654.
  • Yamasaki̇, M., Ki̇tagawa, T., Koyanagi̇, N., Chujo, H., Maeda, H., Kohno-Murase, J., ... & Yamada, K. (2006). Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice. Nutri̇ti̇on, 22(1), 54-59.
There are 44 citations in total.

Details

Primary Language Turkish
Subjects Nutritional Science, Food Properties, Nutrition and Dietetics (Other)
Journal Section Reviews
Authors

Elif Kumbasar 0009-0004-1553-0212

Havvanur Yoldaş İlktaç 0000-0002-7433-6370

Early Pub Date December 3, 2024
Publication Date December 3, 2024
Submission Date October 3, 2024
Acceptance Date November 29, 2024
Published in Issue Year 2024 Volume: 3 Issue: 2

Cite

APA Kumbasar, E., & Yoldaş İlktaç, H. (2024). PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ. Anadolu Üniversitesi Mesleki Eğitim Ve Uygulama Dergisi, 3(2), 197-209. https://doi.org/10.70756/anameud.1560690
AMA Kumbasar E, Yoldaş İlktaç H. PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ. ANAMEUD. December 2024;3(2):197-209. doi:10.70756/anameud.1560690
Chicago Kumbasar, Elif, and Havvanur Yoldaş İlktaç. “PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ”. Anadolu Üniversitesi Mesleki Eğitim Ve Uygulama Dergisi 3, no. 2 (December 2024): 197-209. https://doi.org/10.70756/anameud.1560690.
EndNote Kumbasar E, Yoldaş İlktaç H (December 1, 2024) PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ. Anadolu Üniversitesi Mesleki Eğitim ve Uygulama Dergisi 3 2 197–209.
IEEE E. Kumbasar and H. Yoldaş İlktaç, “PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ”, ANAMEUD, vol. 3, no. 2, pp. 197–209, 2024, doi: 10.70756/anameud.1560690.
ISNAD Kumbasar, Elif - Yoldaş İlktaç, Havvanur. “PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ”. Anadolu Üniversitesi Mesleki Eğitim ve Uygulama Dergisi 3/2 (December 2024), 197-209. https://doi.org/10.70756/anameud.1560690.
JAMA Kumbasar E, Yoldaş İlktaç H. PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ. ANAMEUD. 2024;3:197–209.
MLA Kumbasar, Elif and Havvanur Yoldaş İlktaç. “PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ”. Anadolu Üniversitesi Mesleki Eğitim Ve Uygulama Dergisi, vol. 3, no. 2, 2024, pp. 197-09, doi:10.70756/anameud.1560690.
Vancouver Kumbasar E, Yoldaş İlktaç H. PUNİSİK ASİT VE OLASI SAĞLIK ETKİLERİ. ANAMEUD. 2024;3(2):197-209.

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