Year 2020, Volume 14 , Issue 1, Pages 61 - 67 2020-04-30

Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper)

Ece ALIM [1] , İsmail Nadir GÜLEKON [2] , Kerem ATALAR [3] , Meltem BAHCELIOGLU [4]

The vagus nerve is the primary neural medium which enables gastrointestinal tract and brain communication. Hippocampus, a region of the brain commonly linked to memory function, is activated by vagus nerve-mediated gastrointestinal signals. Vagal afferent information is received by the medial solitary nucleus and is then transmitted via ascending neural pathways to different regions of the forebrain and hindbrain. Explanation of the exact mechanisms of microbiota and amygdala communication requires further research. By linking microbial activities to progressive structural and functional events in the brain in mice models and in humans, we can suggest that intestinal microbiota is an important contributor to neurodevelopment and neurodegeneration. Further researches revealing these relations may provide new approaches for understanding neurodegenerative, psychiatric and behavioral diseases.
enteric nervous system, gut-brain connection, neurodegenerative disease, vagus nerve
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Reviews

Orcid: 0000-0002-4686-0677
Author: Ece ALIM (Primary Author)
Country: Turkey

Author: İsmail Nadir GÜLEKON
Country: Turkey

Author: Kerem ATALAR
Country: Turkey

Author: Meltem BAHCELIOGLU
Country: Turkey


Publication Date : April 30, 2020

Bibtex @review { anatomy679796, journal = {Anatomy}, issn = {}, eissn = {1308-8459}, address = {}, publisher = {Turkish Society of Anatomy and Clinical Anatomy (TSACA)}, year = {2020}, volume = {14}, pages = {61 - 67}, doi = {}, title = {Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper)}, key = {cite}, author = {Alım, Ece and Gülekon, İsmail and Atalar, Kerem and Bahcelıoglu, Meltem} }
APA Alım, E , Gülekon, İ , Atalar, K , Bahcelıoglu, M . (2020). Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper) . Anatomy , 14 (1) , 61-67 . Retrieved from
MLA Alım, E , Gülekon, İ , Atalar, K , Bahcelıoglu, M . "Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper)" . Anatomy 14 (2020 ): 61-67 <>
Chicago Alım, E , Gülekon, İ , Atalar, K , Bahcelıoglu, M . "Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper)". Anatomy 14 (2020 ): 61-67
RIS TY - JOUR T1 - Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper) AU - Ece Alım , İsmail Gülekon , Kerem Atalar , Meltem Bahcelıoglu Y1 - 2020 PY - 2020 N1 - DO - T2 - Anatomy JF - Journal JO - JOR SP - 61 EP - 67 VL - 14 IS - 1 SN - -1308-8459 M3 - UR - Y2 - 2020 ER -
EndNote %0 Anatomy Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper) %A Ece Alım , İsmail Gülekon , Kerem Atalar , Meltem Bahcelıoglu %T Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper) %D 2020 %J Anatomy %P -1308-8459 %V 14 %N 1 %R %U
ISNAD Alım, Ece , Gülekon, İsmail , Atalar, Kerem , Bahcelıoglu, Meltem . "Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper)". Anatomy 14 / 1 (April 2020): 61-67 .
AMA Alım E , Gülekon İ , Atalar K , Bahcelıoglu M . Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper). Anatomy. 2020; 14(1): 61-67.
Vancouver Alım E , Gülekon İ , Atalar K , Bahcelıoglu M . Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper). Anatomy. 2020; 14(1): 61-67.