Review

Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review

Volume: 32 Number: 3 July 28, 2026

Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review

Abstract

Environmental stresses impose a significant threat on plant growth and agricultural productivity. Abiotic stresses, such as drought, salinity, and extreme temperatures, impair plant physiology and development, while biotic stresses, like those caused by pathogens and herbivores, trigger a range of defense responses. Plants have evolved intricate genetic and molecular mechanisms to cope with these challenges. The plant response to stress is governed by transcription factors (TFs), including the AP2/ERF, bZIP, WRKY, and NAC families, which regulate stress responsive gene expression. Phytohormones like ABA, ethylene, and jasmonic acid (JA) serve as crucial signaling molecules that initiate adaptive physiological changes. These signals are transmitted via signal transduction components, such as receptor-like kinases and MAP kinases, which translate external events into cellular responses. Additionally, epigenetic regulation and gene-by-environment (G × E) interactions allow plants to acquire a stress memory and exhibit adaptive plasticity, enhancing their resilience to future challenges. Improving these natural mechanisms is vital for developing stress-tolerant crops. Traditional breeding and modern techniques like Marker-Assisted Selection, Genetic Engineering, Genome Editing and Genomic Selection are used to identify and integrate desirable traits into new crop varieties. These methods enable breeders to develop more robust and stable crops, ultimately helping to ensure global food security in the face of climate change. 

Keywords

References

  1. A Lal M, Kathpalia R, Sisodia R & Shakya R (2018). Biotic Stress, in: Bhatla, S.C., A. Lal, M. (Eds.), Plant Physiology, Development and Metabolism. Springer Nature Singapore, Singapore, pp. 1029-1095. 10.1007/978-981-13-2023-1_32 Abdolmaleky H M, Nohesara S, Zhou J-R & Thiagalingam S (2025). Epigenetics in evolution and adaptation to environmental challenges: pathways for disease prevention and treatment. Epigenomics 17: 317-333. 10.1080/17501911.2025.2464529
  2. Achard P, Cheng H, De Grauwe L, Decat J, Schoutteten H, Moritz T, Van Der Straeten D, Peng J & Harberd N P (2006). Integration of Plant Responses to Environmentally Activated Phytohormonal Signals. Science 311: 91-94. 10.1126/science.1118642
  3. Adunola P, Ferrão L F V, Benevenuto J, Azevedo C F & Munoz P R (2024). Genomic selection optimization in blueberry: Data-driven methods for marker and training population design. The Plant Genome 17: e20488. 10.1002/tpg2.20488
  4. Akhtar M, Jaiswal A, Taj G, Jaiswal J P, Qureshi M I & Singh N K (2012). DREB1/CBF transcription factors: their structure, function and role in abiotic stress tolerance in plants. Journal of Genetics 91: 385-395. 10.1007/s12041-012-0201-3
  5. Akhter Z, Bi Z, Ali K, Sun C, Fiaz S, Haider F U & Bai J (2021). In Response to Abiotic Stress, DNA Methylation Confers EpiGenetic Changes in Plants. Plants 10: 1096. 10.3390/plants10061096
  6. Alemu A, Åstrand J, Montesinos-Lopez O A, y Sanchez J I, Fernandez-Gonzalez J, Tadesse W, Vetukuri R R, Carlsson A S, Ceplitis A & Crossa J (2024). Genomic selection in plant breeding: Key factors shaping two decades of progress. Molecular Plant 17: 552-578. 10.1016/j.molp.2024.03.007
  7. Alghamdi S (2024). Drought and salinity effects on plant growth: A comprehensive review. SABRAO Journal of Breeding and Genetics 56: 2331-2340. 10.54910/sabrao2024.56.6.14.
  8. Ali J, Mukarram M, Ojo J, Dawam N, Riyazuddin R, Ghramh H A, Khan K A, Chen R, Kurjak D & Bayram A (2024). Harnessing Phytohormones: Advancing Plant Growth and Defence Strategies for Sustainable Agriculture. Physiologia Plantarum 176: e14307. 10.1111/ppl.14307

Details

Primary Language

English

Subjects

Plant Biotechnology in Agriculture

Journal Section

Review

Publication Date

July 28, 2026

Submission Date

November 15, 2025

Acceptance Date

February 6, 2026

Published in Issue

Year 2026 Volume: 32 Number: 3

APA
Jalal, A. (2026). Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review. Journal of Agricultural Sciences, 32(3), 564-578. https://doi.org/10.15832/ankutbd.1824410
AMA
1.Jalal A. Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review. J Agr Sci-Tarim Bili. 2026;32(3):564-578. doi:10.15832/ankutbd.1824410
Chicago
Jalal, Areej. 2026. “Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review”. Journal of Agricultural Sciences 32 (3): 564-78. https://doi.org/10.15832/ankutbd.1824410.
EndNote
Jalal A (July 1, 2026) Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review. Journal of Agricultural Sciences 32 3 564–578.
IEEE
[1]A. Jalal, “Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review”, J Agr Sci-Tarim Bili, vol. 32, no. 3, pp. 564–578, July 2026, doi: 10.15832/ankutbd.1824410.
ISNAD
Jalal, Areej. “Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review”. Journal of Agricultural Sciences 32/3 (July 1, 2026): 564-578. https://doi.org/10.15832/ankutbd.1824410.
JAMA
1.Jalal A. Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review. J Agr Sci-Tarim Bili. 2026;32:564–578.
MLA
Jalal, Areej. “Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review”. Journal of Agricultural Sciences, vol. 32, no. 3, July 2026, pp. 564-78, doi:10.15832/ankutbd.1824410.
Vancouver
1.Areej Jalal. Genetic and Molecular Mechanisms of Plant Stress Tolerance and Strategies for Improvement: A Comprehensive Review. J Agr Sci-Tarim Bili. 2026 Jul. 1;32(3):564-78. doi:10.15832/ankutbd.1824410

Journal of Agricultural Sciences is published as open access journal. All articles are published under the terms of the Creative Commons Attribution License (CC BY).