Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate?

Volume: 31 Number: 1 September 11, 2006
  • Zekeriya Isiklar
  • Ismail Tuncay
  • Reha Tandogan
  • Aydin Yuceturk
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Acta Orthopaedica et Traumatologica Turcica
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Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate?

Abstract

An animal model using joint replacement materials was used to compare the efficacy of cefazolin to that of vancomycin/ceftazidime combination in preventing infection from Staphylococcus epidermidis. Forty four New Zealand rabbits had a cobalt-chrome with methacrylate bone cement in the distal femoral metaphysis. Deliberate contamination of the wound with one or two strains of Staphylococcus epidermidis was performed with or without the administration of prophylactic antibiotics and the infection rates compared. Cefazolin prevented infection in only 14% of the animal compared to 86% protected by the combination of vancomycin and ceftazidime. The results were compared with both methicillin sensitive and resistant strains. Epidemiological data and the results of our experiments suggest that the combination of vancomycin and ceftazidime should be considered for contemporary prophylaxis of infection in total joint replacement.

Keywords

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Zekeriya Isiklar This is me

Ismail Tuncay This is me

Reha Tandogan This is me

Aydin Yuceturk This is me

Publication Date

September 11, 2006

Submission Date

March 6, 2014

Acceptance Date

-

Published in Issue

Year 1997 Volume: 31 Number: 1

DOI

https://doi.org/10.3944/aott.v31i1.4219

IZ

https://izlik.org/JA58MS43FM

Cite

RIS / Bibtex
APA
Isiklar, Z., Tuncay, I., Tandogan, R., & Yuceturk, A. (2006). Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica, 31(1), 44-46. https://doi.org/10.3944/aott.v31i1.4219
AMA
1.Isiklar Z, Tuncay I, Tandogan R, Yuceturk A. Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica. 2006;31(1):44-46. doi:10.3944/aott.v31i1.4219
Chicago
Isiklar, Zekeriya, Ismail Tuncay, Reha Tandogan, and Aydin Yuceturk. 2006. “Antibiotic Prophylaxis for the Prevention of Staphylococcus Epidermidis Infections in Orthopedic Surgery: Are First or Second Generation Cephalosporins Adequate?”. Acta Orthopaedica et Traumatologica Turcica 31 (1): 44-46. https://doi.org/10.3944/aott.v31i1.4219.
EndNote
Isiklar Z, Tuncay I, Tandogan R, Yuceturk A (September 1, 2006) Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica 31 1 44–46.
IEEE
[1]Z. Isiklar, I. Tuncay, R. Tandogan, and A. Yuceturk, “Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate?”, Acta Orthopaedica et Traumatologica Turcica, vol. 31, no. 1, pp. 44–46, Sept. 2006, doi: 10.3944/aott.v31i1.4219.
ISNAD
Isiklar, Zekeriya - Tuncay, Ismail - Tandogan, Reha - Yuceturk, Aydin. “Antibiotic Prophylaxis for the Prevention of Staphylococcus Epidermidis Infections in Orthopedic Surgery: Are First or Second Generation Cephalosporins Adequate?”. Acta Orthopaedica et Traumatologica Turcica 31/1 (September 1, 2006): 44-46. https://doi.org/10.3944/aott.v31i1.4219.
JAMA
1.Isiklar Z, Tuncay I, Tandogan R, Yuceturk A. Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica. 2006;31:44–46.
MLA
Isiklar, Zekeriya, et al. “Antibiotic Prophylaxis for the Prevention of Staphylococcus Epidermidis Infections in Orthopedic Surgery: Are First or Second Generation Cephalosporins Adequate?”. Acta Orthopaedica et Traumatologica Turcica, vol. 31, no. 1, Sept. 2006, pp. 44-46, doi:10.3944/aott.v31i1.4219.
Vancouver
1.Zekeriya Isiklar, Ismail Tuncay, Reha Tandogan, Aydin Yuceturk. Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica. 2006 Sep. 1;31(1):44-6. doi:10.3944/aott.v31i1.4219