Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate?

Cilt: 31 Sayı: 1 11 Eylül 2006
  • Zekeriya Isiklar
  • Ismail Tuncay
  • Reha Tandogan
  • Aydin Yuceturk
Acta Orthopaedica et Traumatologica Turcica Kapak
Acta Orthopaedica et Traumatologica Turcica
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Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate?

Abstract

An animal model using joint replacement materials was used to compare the efficacy of cefazolin to that of vancomycin/ceftazidime combination in preventing infection from Staphylococcus epidermidis. Forty four New Zealand rabbits had a cobalt-chrome with methacrylate bone cement in the distal femoral metaphysis. Deliberate contamination of the wound with one or two strains of Staphylococcus epidermidis was performed with or without the administration of prophylactic antibiotics and the infection rates compared. Cefazolin prevented infection in only 14% of the animal compared to 86% protected by the combination of vancomycin and ceftazidime. The results were compared with both methicillin sensitive and resistant strains. Epidemiological data and the results of our experiments suggest that the combination of vancomycin and ceftazidime should be considered for contemporary prophylaxis of infection in total joint replacement.

Keywords

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Zekeriya Isiklar Bu kişi benim

Ismail Tuncay Bu kişi benim

Reha Tandogan Bu kişi benim

Aydin Yuceturk Bu kişi benim

Yayımlanma Tarihi

11 Eylül 2006

Gönderilme Tarihi

6 Mart 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 1997 Cilt: 31 Sayı: 1

DOI

https://doi.org/10.3944/aott.v31i1.4219

IZ

https://izlik.org/JA58MS43FM

Kaynak Göster

RIS / Bibtex
APA
Isiklar, Z., Tuncay, I., Tandogan, R., & Yuceturk, A. (2006). Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica, 31(1), 44-46. https://doi.org/10.3944/aott.v31i1.4219
AMA
1.Isiklar Z, Tuncay I, Tandogan R, Yuceturk A. Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica. 2006;31(1):44-46. doi:10.3944/aott.v31i1.4219
Chicago
Isiklar, Zekeriya, Ismail Tuncay, Reha Tandogan, ve Aydin Yuceturk. 2006. “Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate?”. Acta Orthopaedica et Traumatologica Turcica 31 (1): 44-46. https://doi.org/10.3944/aott.v31i1.4219.
EndNote
Isiklar Z, Tuncay I, Tandogan R, Yuceturk A (01 Eylül 2006) Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica 31 1 44–46.
IEEE
[1]Z. Isiklar, I. Tuncay, R. Tandogan, ve A. Yuceturk, “Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate?”, Acta Orthopaedica et Traumatologica Turcica, c. 31, sy 1, ss. 44–46, Eyl. 2006, doi: 10.3944/aott.v31i1.4219.
ISNAD
Isiklar, Zekeriya - Tuncay, Ismail - Tandogan, Reha - Yuceturk, Aydin. “Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate?”. Acta Orthopaedica et Traumatologica Turcica 31/1 (01 Eylül 2006): 44-46. https://doi.org/10.3944/aott.v31i1.4219.
JAMA
1.Isiklar Z, Tuncay I, Tandogan R, Yuceturk A. Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica. 2006;31:44–46.
MLA
Isiklar, Zekeriya, vd. “Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate?”. Acta Orthopaedica et Traumatologica Turcica, c. 31, sy 1, Eylül 2006, ss. 44-46, doi:10.3944/aott.v31i1.4219.
Vancouver
1.Zekeriya Isiklar, Ismail Tuncay, Reha Tandogan, Aydin Yuceturk. Antibiotic prophylaxis for the prevention of staphylococcus epidermidis infections in orthopedic surgery: are first or second generation cephalosporins adequate? Acta Orthopaedica et Traumatologica Turcica. 01 Eylül 2006;31(1):44-6. doi:10.3944/aott.v31i1.4219