The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee
Abstract
In order to produce early gonarthrosis in rabbits we injected Sulphur-35 (100 mg/kg) which is diluted in carboxymethlyl cellulose suspension. Then we investigated the histopathological changes and PGE-2, LTB-4 levels of the joint hyalin cartilage. The normal value of cartilage tissue PGE-2 and LTB-4 whick was taken from the rabbits knee joint are LTB-4=O.3±0.009 ng/gr and PGE 2=9.6+0. 4 mg/gr. In the samples of the knee joints cartilage tissue which carboxymethlyl cellulose was being injected we found the value of LTB-4 and PGE-2 very close to the normal (LTB4=0.4 ngr/gr and PGE2=10.4 ug/gr). In early degenerativi arthritis of these rabbits, we used diclofenac sodium wash-out. We compared the results of PGE-2, LTB-4 and histopathologic al changes with the control group. In PGE-2 and LTB-4 Ievels of the knee joints injected sulphur we found a great increase when it is compared to the normal conditions (LTB-4=O.8 ng/gr and PGE-2=23.2 mg/gr) The results of wash out with Diclofenac Sodium in experimental gonarthrosis with Sulphur 35 are in 1-2 weeks LTB-4=0. 3±0.002 ng/gr and PGE-2=11.2±0.06 mg/gr and in 3-4 weeks LTB4=0.4±0.009 ng/gr and PGE-2=11.2+0.3mg/gr, we believe that diclofenac sodium can be used in arthroscopic wash out fluid in early gonarthrosis.
Keywords
Deneysel gonartrozda diklofenak sodyumun artroskopik yıkama sıvısında uygulama sonuçları (Hayvan deneyi)
Abstract
Erken dejeneratif artrit geliştirebilmek için tavşanların diz eklemlerine, %2 Karboksi Metil Selülozda seyreltilmiş %2 Sülfür-35 verilmiş ve diz eklemi hyalin kıkırdak doku örneklerinde, Prostoglandin-E2 (PGE-2), Lökotrien-84 (LBT-4) ve histopatolojik olarak deneysel gonartroz araştırılmıştır. Gonartroz oluşturulan bu tavşanlara erken dönemde tedavi amacıyla intraartiküler diklofenak sodyum ile “wash-out” (yıkama) yapıldı. Kıkırdak dokudan alınan doku örneklerinde PGE-2, L TB-4 ve histopatolojik değişiklikler kontrol grupları ile karşılaştırılmış diklofenak sodyum ile artroskopik yıkamanın gonartrozun erken döneminde uygulanabileceği ön kanısına varılmıştır.
Details
| Primary Language | English |
|---|---|
| Journal Section | Experimental Study |
| Authors | |
| Publication Date | September 11, 2006 |
| Published in Issue | Year 1990 Volume: 24 Issue: 5 |