BibTex RIS Kaynak Göster

The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee

Yıl 1990, Cilt: 24 Sayı: 5, 337 - 340, 11.09.2006

Öz

In order to produce early gonarthrosis in rabbits we injected Sulphur-35 (100 mg/kg) which is diluted in carboxymethlyl cellulose suspension. Then we investigated the histopathological changes and PGE-2, LTB-4 levels of the joint hyalin cartilage. The normal value of cartilage tissue PGE-2 and LTB-4 whick was taken from the rabbits knee joint are LTB-4=O.3±0.009 ng/gr and PGE 2=9.6+0. 4 mg/gr. In the samples of the knee joints cartilage tissue which carboxymethlyl cellulose was being injected we found the value of LTB-4 and PGE-2 very close to the normal (LTB4=0.4 ngr/gr and PGE2=10.4 ug/gr). In early degenerativi arthritis of these rabbits, we used diclofenac sodium wash-out. We compared the results of PGE-2, LTB-4 and histopathologic al changes with the control group. In PGE-2 and LTB-4 Ievels of the knee joints injected sulphur we found a great increase when it is compared to the normal conditions (LTB-4=O.8 ng/gr and PGE-2=23.2 mg/gr) The results of wash out with Diclofenac Sodium in experimental gonarthrosis with Sulphur 35 are in 1-2 weeks LTB-4=0. 3±0.002 ng/gr and PGE-2=11.2±0.06 mg/gr and in 3-4 weeks LTB4=0.4±0.009 ng/gr and PGE-2=11.2+0.3mg/gr, we believe that diclofenac sodium can be used in arthroscopic wash out fluid in early gonarthrosis.

Deneysel gonartrozda diklofenak sodyumun artroskopik yıkama sıvısında uygulama sonuçları (Hayvan deneyi)

Yıl 1990, Cilt: 24 Sayı: 5, 337 - 340, 11.09.2006

Öz

Erken dejeneratif artrit geliştirebilmek için tavşanların diz eklemlerine, %2 Karboksi Metil Selülozda seyreltilmiş %2 Sülfür-35 verilmiş ve diz eklemi hyalin kıkırdak doku örneklerinde, Prostoglandin-E2 (PGE-2), Lökotrien-84 (LBT-4) ve histopatolojik olarak deneysel gonartroz araştırılmıştır. Gonartroz oluşturulan bu tavşanlara erken dönemde tedavi amacıyla intraartiküler diklofenak sodyum ile “wash-out” (yıkama) yapıldı. Kıkırdak dokudan alınan doku örneklerinde PGE-2, L TB-4 ve histopatolojik değişiklikler kontrol grupları ile karşılaştırılmış diklofenak sodyum ile artroskopik yıkamanın gonartrozun erken döneminde uygulanabileceği ön kanısına varılmıştır.

Toplam 0 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Deneysel Çalışma
Yazarlar

Mahmut Doral Bu kişi benim

Ertugrul Sener Bu kişi benim

Yayımlanma Tarihi 11 Eylül 2006
Yayımlandığı Sayı Yıl 1990 Cilt: 24 Sayı: 5

Kaynak Göster

APA Doral, M., & Sener, E. (2006). The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica Et Traumatologica Turcica, 24(5), 337-340. https://doi.org/10.3944/aott.v24i5.1178
AMA Doral M, Sener E. The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica et Traumatologica Turcica. Eylül 2006;24(5):337-340. doi:10.3944/aott.v24i5.1178
Chicago Doral, Mahmut, ve Ertugrul Sener. “The Use of Diclofenac Sodium in Arthroscopic Wash-Out Fluid in Experimental Gonarthrosis in Rabbit Knee”. Acta Orthopaedica Et Traumatologica Turcica 24, sy. 5 (Eylül 2006): 337-40. https://doi.org/10.3944/aott.v24i5.1178.
EndNote Doral M, Sener E (01 Eylül 2006) The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica et Traumatologica Turcica 24 5 337–340.
IEEE M. Doral ve E. Sener, “The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee”, Acta Orthopaedica et Traumatologica Turcica, c. 24, sy. 5, ss. 337–340, 2006, doi: 10.3944/aott.v24i5.1178.
ISNAD Doral, Mahmut - Sener, Ertugrul. “The Use of Diclofenac Sodium in Arthroscopic Wash-Out Fluid in Experimental Gonarthrosis in Rabbit Knee”. Acta Orthopaedica et Traumatologica Turcica 24/5 (Eylül 2006), 337-340. https://doi.org/10.3944/aott.v24i5.1178.
JAMA Doral M, Sener E. The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica et Traumatologica Turcica. 2006;24:337–340.
MLA Doral, Mahmut ve Ertugrul Sener. “The Use of Diclofenac Sodium in Arthroscopic Wash-Out Fluid in Experimental Gonarthrosis in Rabbit Knee”. Acta Orthopaedica Et Traumatologica Turcica, c. 24, sy. 5, 2006, ss. 337-40, doi:10.3944/aott.v24i5.1178.
Vancouver Doral M, Sener E. The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica et Traumatologica Turcica. 2006;24(5):337-40.