Abstract
Twelve patients with localized Ewing s sarcoma were treated between 1980-1990 in Istanbul Medical School, Oncology Research-Treatment Center, Our-ChildrenLeukemia Foundation, Department of Pediatric Hematology/Oncology. There were 8 boys and 4 girls, the mean age was 8.1 (range; 3-17) years. The tumors were in the femur in 3 paitents, in the humerus and rib in 2 cases each and in the tibia, radius, vertebra, clavicula and pelvis in 1 case each. Only chemotherapy (CT) was applied to 2 cases, 1 case had CT after radiotherapy. The remaining 9 cases were treated by CT and radiotherapy (during the CT). The CT protocols were VAC (n=5), VACA (n=3), IVAD (n=3), T.9 (n=1) One patient died from the main disease. Remission were achieved in 11 cases. After 5 to 94 months (mean; 22 mo.) 8 cases had relapsed (4 of them had local and remaining had distant metastases). 4 cases were not able to be followed, 3 cases were iost by additional problems (infection, cardiotoxicity). The best prognosis was achieved from Ewing's sarcomas which initiated from long bones, less than 100 ml tumour volumes and patients less than 5 years old. There were no significant differences between chemotherapy protocols.
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Abstract
İstanbul Tıp Fakültesi, Onkoloji Araştırma-Uygulama Merkezi, Bizim Lösemili Çocuklar Vakfı ve Pediatrik Hematoloji-Onkoloji Bilim Dalında 1980-1990 yılları arasında 12 Ewing sarkomu olgusu tedavi edildi. Bunların 8'i erkek, 4'ü kız, yaş ortalamaları 8.1 (dağılım; 3-17) yıl olup, hepsi lokalize hastalık şeklinde başvurmuşlardı. Üç olgu femurdan, 2'şer olgu humerus ve kostalardan, 1'er olgu ise tibia, radius, vertebre, klavikula ve pelvisten köken almıştı. İki olguya sadece kemoterapi, 1 olguya önce radyoterapi sonra kemoterapi (KT), 9 olguya ise KT ve arada radyoterapi uygulandı. 5 olguya VAC, 3'er olguya VACA ve IVAD, 1 olguya da T.9 protokol uygulandı. Bir olgu hastalıktan kaybedildi. 11 olguda remisyon sağlandı. Ortalama 22 ay (dağılım; 5-94) sonra 8 olguda relaps (4'ü lokal, 4'ü metastatik) görüldü. Toplam 4 olgu takipten çıktı, 3 olgu ilave sorunlardan kaybedildi. En iyi prognoz uzun kemiklerden köken alan ve tümör hacmi küçük olan ve 0-5 yaş arası Ewing sarkomlarında sağlandı. Kemoterapi protokolleri arasında fark bulunmadı.
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Details
| Primary Language | English |
|---|---|
| Journal Section | Original Article |
| Authors | |
| Publication Date | September 11, 2006 |
| Published in Issue | Year 1991 Volume: 25 Issue: 4 |