Simvastatin improves spinal fusion in rats

Bora Bostan; Taner Gunes; Murat Asci; Cengiz Sen; Mehmet Kelestemur; Mehmet Erdem; Resit Koseoglu; Unal Erkorkmaz

Research Article

Simvastatinin sıçanlarda spinal füzyona katkısı

Year 2011, Volume: 45 Issue: 4, 270 - 275, 14.09.2011

Bora Bostan Taner Gunes Murat Asci Cengiz Sen Mehmet Kelestemur Mehmet Erdem Resit Koseoglu Unal Erkorkmaz

Abstract

Amaç: Statinler kemik morfogenetik proteinlerinin (BMP-2) üretimini uyararak kemik oluşumuna katkıda bulunurlar. Çalışmamızda, sıçanlarda ağız yoluyla simvastatin alımının spinal füzyon üzerine olan etkilerini araştırmayı hedefledik.
Çalışma planı: Yirmi adet sıçan spinal füzyon grubu (SF; n=10) ve spinal füzyon ve simvastatin grubu (SFS; n=10) olarak rastgele iki gruba bölündü. L4-L6 arasına (her sıçanda toplam 2 seviye) spinal füzyon modeli uygulandı. Simvastatin 120 mg/kg/gün dozunda SFS grubundaki sıçanlara ağız yoluyla verildi. Sıçanlar 12. hafta sonunda öldürüldü.
Bulgular: Elle muayenede SF grubunda 2 orta dereceli füzyon tespit edilirken, SFS grubunda psödoartroz görülmedi. Ortalama 3 nokta eğme testi ile füzyonda yetmezlik oluşturan değerler SFS ve SF gruplarında, sırasıyla, 148.80±39.403 Newton ve 123.80±28.479 Newton olarak tespit edildi (p>0.05). Histolojik skorlamalarda SFS grubunda ortalama 9.30 ±0.949 değerle SF grubundan (ortalama: 6.80±2.044) daha iyi sonuçlar elde edildi (p=0.003). Radyolojik değerlendirmede SF grubunda 2 seviyede Derece C ve 18 seviyede Derece A füzyon tespit edilirken, SFS grubunda 1 seviyede Derece C ve 19 seviyede Derece A füzyon tespit edildi.
Çıkarımlar: Sonuçlarımız simvastatinin spinal füzyona katkıda bulunabileceğini ve yüksek kolesterollü yaşlı hastalarda spinal füzyon girişimlerinde ek ilaç olarak kullanılabileceğini önermektedir.

Keywords

BMP; psödoartroz; simvastatin; spinal füzyon; statin.

Simvastatin improves spinal fusion in rats

Year 2011, Volume: 45 Issue: 4, 270 - 275, 14.09.2011

Bora Bostan Taner Gunes Murat Asci Cengiz Sen Mehmet Kelestemur Mehmet Erdem Resit Koseoglu Unal Erkorkmaz

Abstract

Objective: Statins stimulate bone formation by inducing the expression of bone morphogenetic proteins (BMP-2). The aim of our study was to investigate the effects of orally administered simvastatin on spinal fusion in rats.
Methods: Twenty rats were randomized into a spinal fusion group (SF) (n=10) or a spinal fusion and oral simvastatin administered group (SFS) (n=10). A spinal fusion was performed between L4-L6 representing two levels. Simvastatin (120 mg/kg/day) was administered orally in the SFS group. The rats were killed at the end of the 12 week study period.
Results: Manual palpation revealed two moderate fusions in the SF group. The SFS group did not reveal any signs of pseudoarthrosis. An average three-point bending force causing failure of fusion revealed results of 148.80±39.403 Newtons and 123.80±28.479 Newtons in SFS and SF groups, respectively (p>0.05). Histological examination revealed better fusion grades in the SFS group (mean: 9.30±0.949) than in the SF group (mean: 6.80±2.044) (p=0.003). Radiographic examination revealed Grade C fusion in two levels and Grade A fusion in 18 levels in the SF group. In the SFS group, Grade C fusion was detected in one level and Grade A fusions in 19.
Conclusion: Our results suggest that simvastatin can promote spinal fusion and can be used as an adjunct to spinal fusion procedures in an elderly population with high cholesterol levels.

Keywords

BMP, pseudoarthrosis, simvastatin, spinal fusion, statin

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Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Experimental Study
Authors	Bora Bostan This is me Taner Gunes This is me Murat Asci This is me Cengiz Sen This is me Mehmet Kelestemur This is me Mehmet Erdem This is me Resit Koseoglu This is me Unal Erkorkmaz This is me
Publication Date	September 14, 2011
Published in Issue	Year 2011 Volume: 45 Issue: 4

Cite

APA	Bostan, B., Gunes, T., Asci, M., Sen, C., et al. (2011). Simvastatin improves spinal fusion in rats. Acta Orthopaedica Et Traumatologica Turcica, 45(4), 270-275.
AMA	Bostan B, Gunes T, Asci M, Sen C, Kelestemur M, Erdem M, Koseoglu R, Erkorkmaz U. Simvastatin improves spinal fusion in rats. Acta Orthopaedica et Traumatologica Turcica. September 2011;45(4):270-275.
Chicago	Bostan, Bora, Taner Gunes, Murat Asci, Cengiz Sen, Mehmet Kelestemur, Mehmet Erdem, Resit Koseoglu, and Unal Erkorkmaz. “Simvastatin Improves Spinal Fusion in Rats”. Acta Orthopaedica Et Traumatologica Turcica 45, no. 4 (September 2011): 270-75.
EndNote	Bostan B, Gunes T, Asci M, Sen C, Kelestemur M, Erdem M, Koseoglu R, Erkorkmaz U (September 1, 2011) Simvastatin improves spinal fusion in rats. Acta Orthopaedica et Traumatologica Turcica 45 4 270–275.
IEEE	B. Bostan, T. Gunes, M. Asci, C. Sen, M. Kelestemur, M. Erdem, R. Koseoglu, and U. Erkorkmaz, “Simvastatin improves spinal fusion in rats”, Acta Orthopaedica et Traumatologica Turcica, vol. 45, no. 4, pp. 270–275, 2011.
ISNAD	Bostan, Bora et al. “Simvastatin Improves Spinal Fusion in Rats”. Acta Orthopaedica et Traumatologica Turcica 45/4 (September 2011), 270-275.
JAMA	Bostan B, Gunes T, Asci M, Sen C, Kelestemur M, Erdem M, Koseoglu R, Erkorkmaz U. Simvastatin improves spinal fusion in rats. Acta Orthopaedica et Traumatologica Turcica. 2011;45:270–275.
MLA	Bostan, Bora et al. “Simvastatin Improves Spinal Fusion in Rats”. Acta Orthopaedica Et Traumatologica Turcica, vol. 45, no. 4, 2011, pp. 270-5.
Vancouver	Bostan B, Gunes T, Asci M, Sen C, Kelestemur M, Erdem M, Koseoglu R, Erkorkmaz U. Simvastatin improves spinal fusion in rats. Acta Orthopaedica et Traumatologica Turcica. 2011;45(4):270-5.