Ailesel Akdeniz Ateşi ve Psoriazisi Olan Bir Hastada Multipl Skleroz: Bir Olgu Sunumu ve Literatürün Gözden Geçirilmesi

Abstract

FMF hastalarında ataksız dönemlerde bile subklinik inflamasyon vardır. İnflamatuvar yanıtın neden olduğu bu sürekli enflamasyon ve MEFV mutasyonunun varlığı, FMF'li hastaları başka enflamatuvar bozukluklar geliştirmeye yatkın hale getirebilir. Ayrıca MS'li hastalarda özellikle MS tanısından önce başka otoimmün hastalıklara sahip olma olasılığı daha yüksektir. Homozigot M694V gen mutasyonu olan, FMF ve psoriazis(PsO) tanısı almış bir hastada gelişen multipl skleroz olgusunu bildirdik. Hasta son iki yıldır FMF atağı geçirmiyordu. Hastanın başvuru anında atak yoktu. Hastada FMF tanısı konulduktan 2 yıl sonra psoriazis, 10 yıl sonra da multipl skleroz gelişti.

Keywords

• Demiyelinizan hastalık
• MEFV mutasyonu
• Multipl skleroz
• Psöriazis

Multiple Sclerosis in a Patient witth Familial Mediterranean Fever and Psoriasis: a Case Report and Review of the Literature

Abstract

In patients with FMF, there is a subclinical inflammation even during attack-free periods. This continued inflammation conferred by inflammatory response and the presence of MEFV mutation may predispose patients with FMF to developing other inflammatory disorders. Also, patients with MS are more likely to have other autoimmune disorders particularly prior to the diagnosis of MS. We reported a case of multiple sclerosis developing in a patient had the homozygous M694V gene mutation and diagnosed with fmf and psoriasis(PsO). The patient had been FMF attack free for the past two years. The patient was no attack at the time of admission. After FMF diagnosed in patient, psoriasis developed 2 years later and multiple sclerosis 10 years later.

Keywords

• Demyelinating disease
• MEFV mutation
• Multiple sclerosis; Familial mediterranean fever

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