Case Report
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Ailesel Akdeniz Ateşi ve Psoriazisi Olan Bir Hastada Multipl Skleroz: Bir Olgu Sunumu ve Literatürün Gözden Geçirilmesi

Year 2023, Volume: 7 Issue: 1, 33 - 37, 29.04.2023

Abstract

FMF hastalarında ataksız dönemlerde bile subklinik inflamasyon vardır. İnflamatuvar yanıtın neden olduğu bu sürekli enflamasyon ve MEFV mutasyonunun varlığı, FMF'li hastaları başka enflamatuvar bozukluklar geliştirmeye yatkın hale getirebilir. Ayrıca MS'li hastalarda özellikle MS tanısından önce başka otoimmün hastalıklara sahip olma olasılığı daha yüksektir. Homozigot M694V gen mutasyonu olan, FMF ve psoriazis(PsO) tanısı almış bir hastada gelişen multipl skleroz olgusunu bildirdik. Hasta son iki yıldır FMF atağı geçirmiyordu. Hastanın başvuru anında atak yoktu. Hastada FMF tanısı konulduktan 2 yıl sonra psoriazis, 10 yıl sonra da multipl skleroz gelişti.

References

  • Akman, D.G., Gül, A., Gürol, E., Özdoğan, H., Bahar, S., Oge, A.E., Gurvit, H., Saruhan, D.G., Yazıcı, H. and Eraksoy, M. (2006). Infammatory/demyelinating central nervous system involvement in familial Mediterranean fever (FMF): coincidence or association? Journal of Neurology, 253,928-934.
  • Ashida, M., Koike, Y., Kuwatsuka, S., Ichinose, K., Migita, K., Sano, S. and Utani, A. (2016). Psoriasis-like lesions in a patient with familial Mediterranean fever. The Journal of Dermatology, 43(3), 314-7.
  • Atas, N., Armagan, B., Bodakci, E., Satis, H., Sari, A., Bilge, N.S.Y., Salman, B.Y., Yardimci, K.G., Babaoglu, H., Guler, A.A., Karadeniz, H., Kilic, L., Ozturk, M.A., Goker, B., Haznedaroglu, S., Kalyoncu, U., Kasifoglu, T. and Tufan, A. (2020). Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: Results from a large cohort study. Rheumatology International, 40, 41-48.
  • Egeberg, A., Mallbris, L., Gislason, G.H., Skov, L. and Hansen, P.R. (2016). Risk of multiple sclerosis in patients with psoriasis: a Danish nationwide cohort study. Journal of Investigative Dermatology, 136(1),93–98.
  • Elhani, I., Dumont, A., Vergneault, H., Ardois, S., Le Besnerais, M., Levesque, H., Ouallet, J.C., Savey, L., Aouba, A., Amselem, S., Giurgea, I., Capron, J., Grateau, G. and Laviallle, G.S. (2021). Association between familial Mediterranean fever and multiple sclerosis: A case series from the JIR cohort and systematic literature review. Multiple Sclerosis and Related Disorders, 50,102834
  • Erden, A., Batu, E.D., Seyhoğlu, E., Sari, A., Sönmez, H.E., Armagan, B., Demir, S., Bilgin, E., Kilic, L., Karadag, O., Akdogan, A., Bilginer, Y., Ertenli, İ., Kiraz, S., Bilgen, A.S. and Kalyoncu, U. (2018). Increased psoriasis frequency in patients with familial Mediterranean fever. Upsala Journal of Medical Science, 123(1), 57-61.
  • Fellner, A., Dano, M., Regev, K., Mosek, A. and Karni, A. (2014). Multiple sclerosis is associated with psoriasis. A case-control study. Journal of The Neurological Science, 338(1-2), 226-228.
  • Güncan, S., Bilge, N.Ş., Cansu, D.Ü., Kaşifoğlu, T. and Korkmaz, C. (2016). The role of MEFV mutations in the concurrent disorders observed in patients with familial Mediterranean fever. European Journal of Rheumatology, 3(3), 118-121.
  • Kaiser, S.A.S., Homan, K.B. and Mansouri, B. (2019) A narrative review of psoriasis and multiple sclerosis: links and risks. Psoriasis (Auckl), 22(9),81-90.
  • Kalyoncu, U., Eker, A., Oguz, K.K., Kurne, A., Kalan, I., Topcuoglu, A.M., Anlar, B., Bilginer, Y., Arıcı, M., Yılmaz, E., Kiraz, S., Calguneri, M. and Karabudak, R. (2010). Familial Mediterranean fever and central nervous system involvement: A case series. Medicine (Baltimore), 89(2):75-84.
  • Korkmaz, C., Üsküdar, C.D. and Kabay, S.C. (2022). Familial coexistence of demyelinating diseases and familial Mediterranean fever. Rheumatology International, 42(1), 167-173.
  • Langer, G.A., Albers, K., Van Den Eeden, S. and Nelson, L. (2010), Autoimmune diseases prior to the diagnosis of multiple sclerosis: A population-based case-control study. Multiple Sclerosis Journal, 16(7),855-861.
  • Salehzadeh, F. and Enteshari, M.A. (2020). Coexisting diseases in patients with familial mediterranean fever. Open Access Rheumatology, 12, 65-71.
  • Trebst, C., Kümpfel, T. (2010) Neuroimmunologie und Rheumatologie: Schnittmengen und Differenzialdiagnosen. Der Nervenarzt, 89, 1095-1105.
  • Unal, A., Dursun, A., Emre, U., Tascilar, N.F. and Ankarali, H. (2010). Evaluation of common mutations in the Mediterranean fever gene in multiple sclerosis patients, is it a susceptibility gene? Journal of the Neurological Science, 294(1-2), 38-42.

Multiple Sclerosis in a Patient witth Familial Mediterranean Fever and Psoriasis: a Case Report and Review of the Literature

Year 2023, Volume: 7 Issue: 1, 33 - 37, 29.04.2023

Abstract

In patients with FMF, there is a subclinical inflammation even during attack-free periods. This continued inflammation conferred by inflammatory response and the presence of MEFV mutation may predispose patients with FMF to developing other inflammatory disorders. Also, patients with MS are more likely to have other autoimmune disorders particularly prior to the diagnosis of MS. We reported a case of multiple sclerosis developing in a patient had the homozygous M694V gene mutation and diagnosed with fmf and psoriasis(PsO). The patient had been FMF attack free for the past two years. The patient was no attack at the time of admission. After FMF diagnosed in patient, psoriasis developed 2 years later and multiple sclerosis 10 years later.

References

  • Akman, D.G., Gül, A., Gürol, E., Özdoğan, H., Bahar, S., Oge, A.E., Gurvit, H., Saruhan, D.G., Yazıcı, H. and Eraksoy, M. (2006). Infammatory/demyelinating central nervous system involvement in familial Mediterranean fever (FMF): coincidence or association? Journal of Neurology, 253,928-934.
  • Ashida, M., Koike, Y., Kuwatsuka, S., Ichinose, K., Migita, K., Sano, S. and Utani, A. (2016). Psoriasis-like lesions in a patient with familial Mediterranean fever. The Journal of Dermatology, 43(3), 314-7.
  • Atas, N., Armagan, B., Bodakci, E., Satis, H., Sari, A., Bilge, N.S.Y., Salman, B.Y., Yardimci, K.G., Babaoglu, H., Guler, A.A., Karadeniz, H., Kilic, L., Ozturk, M.A., Goker, B., Haznedaroglu, S., Kalyoncu, U., Kasifoglu, T. and Tufan, A. (2020). Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: Results from a large cohort study. Rheumatology International, 40, 41-48.
  • Egeberg, A., Mallbris, L., Gislason, G.H., Skov, L. and Hansen, P.R. (2016). Risk of multiple sclerosis in patients with psoriasis: a Danish nationwide cohort study. Journal of Investigative Dermatology, 136(1),93–98.
  • Elhani, I., Dumont, A., Vergneault, H., Ardois, S., Le Besnerais, M., Levesque, H., Ouallet, J.C., Savey, L., Aouba, A., Amselem, S., Giurgea, I., Capron, J., Grateau, G. and Laviallle, G.S. (2021). Association between familial Mediterranean fever and multiple sclerosis: A case series from the JIR cohort and systematic literature review. Multiple Sclerosis and Related Disorders, 50,102834
  • Erden, A., Batu, E.D., Seyhoğlu, E., Sari, A., Sönmez, H.E., Armagan, B., Demir, S., Bilgin, E., Kilic, L., Karadag, O., Akdogan, A., Bilginer, Y., Ertenli, İ., Kiraz, S., Bilgen, A.S. and Kalyoncu, U. (2018). Increased psoriasis frequency in patients with familial Mediterranean fever. Upsala Journal of Medical Science, 123(1), 57-61.
  • Fellner, A., Dano, M., Regev, K., Mosek, A. and Karni, A. (2014). Multiple sclerosis is associated with psoriasis. A case-control study. Journal of The Neurological Science, 338(1-2), 226-228.
  • Güncan, S., Bilge, N.Ş., Cansu, D.Ü., Kaşifoğlu, T. and Korkmaz, C. (2016). The role of MEFV mutations in the concurrent disorders observed in patients with familial Mediterranean fever. European Journal of Rheumatology, 3(3), 118-121.
  • Kaiser, S.A.S., Homan, K.B. and Mansouri, B. (2019) A narrative review of psoriasis and multiple sclerosis: links and risks. Psoriasis (Auckl), 22(9),81-90.
  • Kalyoncu, U., Eker, A., Oguz, K.K., Kurne, A., Kalan, I., Topcuoglu, A.M., Anlar, B., Bilginer, Y., Arıcı, M., Yılmaz, E., Kiraz, S., Calguneri, M. and Karabudak, R. (2010). Familial Mediterranean fever and central nervous system involvement: A case series. Medicine (Baltimore), 89(2):75-84.
  • Korkmaz, C., Üsküdar, C.D. and Kabay, S.C. (2022). Familial coexistence of demyelinating diseases and familial Mediterranean fever. Rheumatology International, 42(1), 167-173.
  • Langer, G.A., Albers, K., Van Den Eeden, S. and Nelson, L. (2010), Autoimmune diseases prior to the diagnosis of multiple sclerosis: A population-based case-control study. Multiple Sclerosis Journal, 16(7),855-861.
  • Salehzadeh, F. and Enteshari, M.A. (2020). Coexisting diseases in patients with familial mediterranean fever. Open Access Rheumatology, 12, 65-71.
  • Trebst, C., Kümpfel, T. (2010) Neuroimmunologie und Rheumatologie: Schnittmengen und Differenzialdiagnosen. Der Nervenarzt, 89, 1095-1105.
  • Unal, A., Dursun, A., Emre, U., Tascilar, N.F. and Ankarali, H. (2010). Evaluation of common mutations in the Mediterranean fever gene in multiple sclerosis patients, is it a susceptibility gene? Journal of the Neurological Science, 294(1-2), 38-42.
There are 15 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Reports
Authors

Songül İnce 0000-0002-5006-6409

Gökçe Zeytin Demirel 0000-0002-9635-5804

Selin Betaş Akın 0000-0002-7372-2907

Ülkü Türk Börü This is me 0000-0002-0094-5624

Publication Date April 29, 2023
Published in Issue Year 2023 Volume: 7 Issue: 1

Cite

APA İnce, S., Demirel, G. Z., Akın, S. B., Börü, Ü. T. (2023). Multiple Sclerosis in a Patient witth Familial Mediterranean Fever and Psoriasis: a Case Report and Review of the Literature. Arel Üniversitesi Sağlık Bilimleri Dergisi, 7(1), 33-37.
AMA İnce S, Demirel GZ, Akın SB, Börü ÜT. Multiple Sclerosis in a Patient witth Familial Mediterranean Fever and Psoriasis: a Case Report and Review of the Literature. J. H. Sci. Arel U. April 2023;7(1):33-37.
Chicago İnce, Songül, Gökçe Zeytin Demirel, Selin Betaş Akın, and Ülkü Türk Börü. “Multiple Sclerosis in a Patient Witth Familial Mediterranean Fever and Psoriasis: A Case Report and Review of the Literature”. Arel Üniversitesi Sağlık Bilimleri Dergisi 7, no. 1 (April 2023): 33-37.
EndNote İnce S, Demirel GZ, Akın SB, Börü ÜT (April 1, 2023) Multiple Sclerosis in a Patient witth Familial Mediterranean Fever and Psoriasis: a Case Report and Review of the Literature. Arel Üniversitesi Sağlık Bilimleri Dergisi 7 1 33–37.
IEEE S. İnce, G. Z. Demirel, S. B. Akın, and Ü. T. Börü, “Multiple Sclerosis in a Patient witth Familial Mediterranean Fever and Psoriasis: a Case Report and Review of the Literature”, J. H. Sci. Arel U., vol. 7, no. 1, pp. 33–37, 2023.
ISNAD İnce, Songül et al. “Multiple Sclerosis in a Patient Witth Familial Mediterranean Fever and Psoriasis: A Case Report and Review of the Literature”. Arel Üniversitesi Sağlık Bilimleri Dergisi 7/1 (April 2023), 33-37.
JAMA İnce S, Demirel GZ, Akın SB, Börü ÜT. Multiple Sclerosis in a Patient witth Familial Mediterranean Fever and Psoriasis: a Case Report and Review of the Literature. J. H. Sci. Arel U. 2023;7:33–37.
MLA İnce, Songül et al. “Multiple Sclerosis in a Patient Witth Familial Mediterranean Fever and Psoriasis: A Case Report and Review of the Literature”. Arel Üniversitesi Sağlık Bilimleri Dergisi, vol. 7, no. 1, 2023, pp. 33-37.
Vancouver İnce S, Demirel GZ, Akın SB, Börü ÜT. Multiple Sclerosis in a Patient witth Familial Mediterranean Fever and Psoriasis: a Case Report and Review of the Literature. J. H. Sci. Arel U. 2023;7(1):33-7.

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