Kemik İliği Stroması: Hücreleri ve Mikroçevresi

Aynur Karadağ; Buket Altınok; Tülin Özkan; Yalda Hekmatshoar

doi:10.1501/Ashd_0000000130

EN TR

Abstract

Bone marrow is a specialized site of structural stromal cells of immature and mature blood cells. It is found in bones such as the human skull, rib cage, ribs, pelvis and femur. Bone marrow is connected to the invention and circulation through specialized blood vessels, including specialized fenestrated capillaries called sinusoids. These sinusoids penetrate sponge-like extracellular cells which is produced by fibroblasts, and place hematopoietic cells, proteins in separate compartments. Bone marrow contains specialized microchips containing hematopoietic cells, stromal cells, ECM, cytokines, growth factors and chemokines. In this microenvironment, developing hematopoietic cells are signaling for survival, differentiation and proliferation. Bone marrow microenvironment plays an important role in the development and progression of leukemia and other types of cancer. In many ways, bone marrow provides an ideal microenvironment for growth of malignant cells. In this review, general information about the role of the bone marrow microenvironment and the cells forming the microenvironment is given

Keywords

Bone marrow, Hematopoietic stem cell, Mesenchymal stem cell, Microenvironment

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Aynur Karadağ This is me

Buket Altınok This is me

Tülin Özkan This is me

Yalda Hekmatshoar This is me

Publication Date

October 1, 2017

Submission Date

October 1, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 16 Number: 2

DOI

https://doi.org/10.1501/Ashd_0000000130

IZ

https://izlik.org/JA96NF56RX

APA

Karadağ, A., Altınok, B., Özkan, T., & Hekmatshoar, Y. (2017). Kemik İliği Stroması: Hücreleri ve Mikroçevresi. Ankara Sağlık Hizmetleri Dergisi, 16(2), 51-62. https://doi.org/10.1501/Ashd_0000000130

AMA

1.Karadağ A, Altınok B, Özkan T, Hekmatshoar Y. Kemik İliği Stroması: Hücreleri ve Mikroçevresi. Ankara Sağlık Hizmetleri Dergisi. 2017;16(2):51-62. doi:10.1501/Ashd_0000000130

Chicago

Karadağ, Aynur, Buket Altınok, Tülin Özkan, and Yalda Hekmatshoar. 2017. “Kemik İliği Stroması: Hücreleri Ve Mikroçevresi”. Ankara Sağlık Hizmetleri Dergisi 16 (2): 51-62. https://doi.org/10.1501/Ashd_0000000130.

EndNote

Karadağ A, Altınok B, Özkan T, Hekmatshoar Y (October 1, 2017) Kemik İliği Stroması: Hücreleri ve Mikroçevresi. Ankara Sağlık Hizmetleri Dergisi 16 2 51–62.

IEEE

[1]A. Karadağ, B. Altınok, T. Özkan, and Y. Hekmatshoar, “Kemik İliği Stroması: Hücreleri ve Mikroçevresi”, Ankara Sağlık Hizmetleri Dergisi, vol. 16, no. 2, pp. 51–62, Oct. 2017, doi: 10.1501/Ashd_0000000130.

ISNAD

Karadağ, Aynur - Altınok, Buket - Özkan, Tülin - Hekmatshoar, Yalda. “Kemik İliği Stroması: Hücreleri Ve Mikroçevresi”. Ankara Sağlık Hizmetleri Dergisi 16/2 (October 1, 2017): 51-62. https://doi.org/10.1501/Ashd_0000000130.

JAMA

1.Karadağ A, Altınok B, Özkan T, Hekmatshoar Y. Kemik İliği Stroması: Hücreleri ve Mikroçevresi. Ankara Sağlık Hizmetleri Dergisi. 2017;16:51–62.

MLA

Karadağ, Aynur, et al. “Kemik İliği Stroması: Hücreleri Ve Mikroçevresi”. Ankara Sağlık Hizmetleri Dergisi, vol. 16, no. 2, Oct. 2017, pp. 51-62, doi:10.1501/Ashd_0000000130.

Vancouver

1.Aynur Karadağ, Buket Altınok, Tülin Özkan, Yalda Hekmatshoar. Kemik İliği Stroması: Hücreleri ve Mikroçevresi. Ankara Sağlık Hizmetleri Dergisi. 2017 Oct. 1;16(2):51-62. doi:10.1501/Ashd_0000000130

Abstract

Keywords