The Role of Superoxide Dismutase (SOD) Activity And Malondialdehyde (MDA) Levels in The Differentiation of Benign-Malign Pleural Effusion

Year 2004, , 39 - 43, 01.05.2004

Ulukavak Çiftçi Tansu Yıldız Güney Ayşe Bilgehan Filiz Çimen

https://doi.org/10.1501/Ashd_0000000053

Abstract

Giriş:Serbest radikaller birçok hastalığın
patogenezinde yer alan yüksek oranda oksijen
içeren moleküllerdir. Serbest radikal oluşumu
ile antioksidan savunma sistemi arasında kritik
bir denge vardır. Oksidatif stresin malignensi
ile birlikte olduğu bilinmektedir. Pleural
effüzyon (PE) bronkojenik malignensi
komplikasyonu olarak nadir değildir fakat
diğer bazı hastalıklarda da PE görülebilir. Bu
çalışmanın amacı malign ve benign hastalarda
pleural sıvıdaki malondialdehide (MDA)
seviyesi ve antioksidant enzim süperoksid
dismutaz (SOD) aktivitesinin arasında
herhangi bir fark olup olmadığını saptamaktır.
Gereç ve Yöntem:Bu çalışmaya
kırksekiz hasta dahil edildi. Grup I’de 24
malign pleural effüzyonlu hasta ve grup II’de
ise 24 benign pleural effüzyonlu hasta vardı.
MDA seviyesi ve SOD aktivitesi pleural
sıvıda incelendi.
Sonuçlar:MDA seviyesi Grup I’de
(135,15 ± 18,95 nmol/ml) group II’ ye göre
belirgin olarak yüksektir (67,35 ± 13,02
nmol/ml) (p<0,001). SOD aktivitesi ise grup
I’de grup II ile karşılaştırıldığında anlamlı Tartışma: Bu sonuçlarımız reaktif
oksijen türlerinin malign pleural sıvıda SOD
aktivitesi ile birlikte arttığını göstermektedir.
Bu parametreler malign efüzyonu bening
efüzyondan ayırmak için non-spesifik bir
diagnostik markır olabili

Keywords

Pleural efüzyon, SOD, MDA

The Role Of Superoxide Dismutase(SOD) Activity And Malondialdehyde(MDA) Levels In The Differentiation OfBenign-Malign Pleural Effusion

Abstract

Introduction: Free radicals are highly
reactive oxygen-containing molecular species
that have been implicated in the pathogenesis
of many diseases. There is a critical balance
between free radical generation and
antioxidant defenses. It has been suggested that
oxidative stress may be associated with
malignancy. Pleural effusions (PE)
complicating bronchogenic malignancy is not
uncommon but many diseases that cause PE
are also present. The aim of our study was to
assess the level of the malondialdehide (MDA)
and antioxidant enzyme superoxide dismutase
(SOD), in pleural fluids of malign and benign
patients.
Material and Methods: Forty-eight
patients were enrolled into the study. Group I
had 24 cases with malign pleural effusion and
group II had 24 cases with benign pleural
effusion. The MDA levels and SOD activities
in pleural fluid were quantified.
Results: There was a significant increase
in MDA levels in group I (135,15 ± 18,95
nmol/ml) than in group II (67,35 ± 13,02
nmol/ml) (p<0,001). The activities of SOD is
found to be increased significantly in group I
when compared to group II (40,33 ± 7,1 U/ml
vs 33,2 ± 6,2 U/ml) (p< 0,05).
Discussion: These findings may support
the previous findings showing that reactive
oxygen species increased in malignant pleural
fluid with increased activities of SOD. These
parameters might be helpful in differation of
malign from benign effusion and could be used
as non-spesific diagnostic markers.

Keywords

Pleural effusion, SOD, MDA

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