The Role of Superoxide Dismutase (SOD) Activity And Malondialdehyde (MDA) Levels in The Differentiation of Benign-Malign Pleural Effusion

Abstract

Giriş:Serbest radikaller birçok hastalığın patogenezinde yer alan yüksek oranda oksijen içeren moleküllerdir. Serbest radikal oluşumu ile antioksidan savunma sistemi arasında kritik bir denge vardır. Oksidatif stresin malignensi ile birlikte olduğu bilinmektedir. Pleural effüzyon (PE) bronkojenik malignensi komplikasyonu olarak nadir değildir fakat diğer bazı hastalıklarda da PE görülebilir. Bu çalışmanın amacı malign ve benign hastalarda pleural sıvıdaki malondialdehide (MDA) seviyesi ve antioksidant enzim süperoksid dismutaz (SOD) aktivitesinin arasında herhangi bir fark olup olmadığını saptamaktır. Gereç ve Yöntem:Bu çalışmaya kırksekiz hasta dahil edildi. Grup I’de 24 malign pleural effüzyonlu hasta ve grup II’de ise 24 benign pleural effüzyonlu hasta vardı. MDA seviyesi ve SOD aktivitesi pleural sıvıda incelendi. Sonuçlar:MDA seviyesi Grup I’de (135,15 ± 18,95 nmol/ml) group II’ ye göre belirgin olarak yüksektir (67,35 ± 13,02 nmol/ml) (p<0,001). SOD aktivitesi ise grup I’de grup II ile karşılaştırıldığında anlamlı Tartışma: Bu sonuçlarımız reaktif oksijen türlerinin malign pleural sıvıda SOD aktivitesi ile birlikte arttığını göstermektedir. Bu parametreler malign efüzyonu bening efüzyondan ayırmak için non-spesifik bir diagnostik markır olabili

Keywords

• Pleural efüzyon
• SOD
• MDA

The Role Of Superoxide Dismutase(SOD) Activity And Malondialdehyde(MDA) Levels In The Differentiation OfBenign-Malign Pleural Effusion

Abstract

Introduction: Free radicals are highly reactive oxygen-containing molecular species that have been implicated in the pathogenesis of many diseases. There is a critical balance between free radical generation and antioxidant defenses. It has been suggested that oxidative stress may be associated with malignancy. Pleural effusions (PE) complicating bronchogenic malignancy is not uncommon but many diseases that cause PE are also present. The aim of our study was to assess the level of the malondialdehide (MDA) and antioxidant enzyme superoxide dismutase (SOD), in pleural fluids of malign and benign patients. Material and Methods: Forty-eight patients were enrolled into the study. Group I had 24 cases with malign pleural effusion and group II had 24 cases with benign pleural effusion. The MDA levels and SOD activities in pleural fluid were quantified. Results: There was a significant increase in MDA levels in group I (135,15 ± 18,95 nmol/ml) than in group II (67,35 ± 13,02 nmol/ml) (p<0,001). The activities of SOD is found to be increased significantly in group I when compared to group II (40,33 ± 7,1 U/ml vs 33,2 ± 6,2 U/ml) (p< 0,05). Discussion: These findings may support the previous findings showing that reactive oxygen species increased in malignant pleural fluid with increased activities of SOD. These parameters might be helpful in differation of malign from benign effusion and could be used as non-spesific diagnostic markers.

Keywords

• Pleural effusion
• SOD
• MDA

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