Serviks kanserinde radyoterapi tedavisinin yeri ve önemi

Abstract

Serviks kanseri jinekolojik kanserler içinde sıklık açısından ikinci sırada yer almaktadır. Radyoterapi, yaklaşık yüzyıllık süreçte serviks kanseri tedavisinde kullanılmaktadır. Özellikle de lokal ileri hastalıkta ilk tedavi seçeneği olmuştur. Tek başına eksternal radyoterapi büyük tümörlerde düşük kontrol oranı sağlamaktadır. Serviks kanserinde brakiterapinin de kullanılması ile büyük tümörlerin kontrol oranları yükselmiştir. Son yıllarda radyoterapinin etkinliğini arttırmak amacıyla kemoradyoterapinin birlikte kullanımı gündeme gelmiştir. Kemoradyoterapi çalışmalarında en sık sisplatin, 5-FU, mitomisin-C ve hidroksiüre kullanılmıştır. Bu çalışmaların sonucunda kemoradyoterapinin uygulandığı randomize çalışmalarda görülmüştür ki serviks kanserinde kemoradyoterapi uygulanmasının, özellikle de sisplatinin sağkalım avantajı sağladığı gösterilmiştir

Keywords

• Serviks kanseri
• radyoterapi
• kemoradyoterapi

Abstract

Cervical cancer ranks second in terms of frequency of gynecological cancers. Radiation therapy used to treat cervical cancer in the process nearly a century. In particular, became first-line treatment in locally advanced disease. Provides a low control rate in large tumors with external beam radiotherapy alone. Large tumors with the use of brachytherapy in cervical cancer control rates were also increased. The most common work chemoradiotherapy cisplatin, 5-FU and mitomycin-C, hydroxyurea, is used. Suffered as a result of these studies, randomized trials that applied chemoradiotherapy implementation of chemoradiation in cervical cancer, especially cisplatin shown to provide a survival advantagein recent years, in order to increase the effectiveness of radiotherapy with chemoradiotherapy was introduced

Keywords

• Cervical Cancer
• Radiotherapy
• Chemoradiotherapy

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