Kemik İliği Stroması: Hücreleri ve Mikroçevresi

Year 2017, Volume: 16 Issue: 2, 51 - 62, 01.10.2017

Aynur Karadağ Buket Altınok Tülin Özkan Yalda Hekmatshoar

https://doi.org/10.1501/Ashd_0000000130

Abstract

Kemik iliği olgunlaşmamış ve olgunlaşmış kan hücrelerinin yapısal stromal hücrelerle kapatıldığı özel bir yerdir. Bu süngerimsi yağ dokusu, insan kafatası, göğüs kafesi, kaburgalar, pelvis ve femurlar gibi kemiklerin içinde bulunur. Kemik iliği, sinüzoid olarak adlandırılan özelleştirilmiş fenestra kapiller dahil olmak üzere, uzmanlaşmış kan damarları aracılığıyla beslenir ve dolaşıma bağlanır. Bu sinüzoidler retiküler fibroblastlar tarafından üretilen sünger benzeri hücre dışı matrise (ECM) nüfuz eder ve bu hücreler ve proteinler, hematopoietik hücreleri ayrı bölmelere yerleştirir. Kemik iliğinde, hematopoietik hücreler, stromal hücreler, ECM, sitokinler, büyüme faktörleri ve kemokinler ihtiva eden özel mikroçevreler bulunur. Bu mikroçevrede gelişmekte olan hematopoietik hücreler hayatta kalmak, farklılaşmak ve çoğalmak için sinyal alırlar. Kemik iliği mikroçevresi löseminin ve diğer kanser türlerinin gelişiminde ve ilerlemesinde önemli bir rol oynamaktadır. Birçok yönden, kemik iliği malign hücrelerin büyümesi için ideal bir mikroçevre sağlamaktadır. Bu derlemede, kemik iliği mikroçevresinin görevi ve mikroçevreyi oluşturan hücrelerin hakkında genel bilgi verilmiştir

Keywords

Kemik iliği, Hematopoetik kök hücre, Mezenkimal kök hücre, Mikroçevre

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