Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Olgularda Monosit / Yüksek Yoğunluklu Lipoprotein (HDL) Oranı

Year 2025, Volume: 5 Issue: 3, 87 - 92, 23.09.2025

Ebru Turan , Tuğba Menteşe Babayiğit

Abstract

Amaç: Dikkat Eksikliği ve Hiperaktivite Bozukluğu (DEHB), dikkatsizlik, hiperaktivite ve dürtüsellik ile karakterize yaygın bir nörogelişimsel bozukluktur. Son çalışmalar, immün disregülasyon ve inflamasyonun DEHB’nin patofizyolojisinde rol oynayabileceğini öne sürmektedir. Monosit-yüksek yoğunluklu lipoprotein (HDL) oranı (MHR), yeni bir enflamatuar belirteç olarak önerilmiştir. Bu çalışmanın amacı, DEHB ve MHR arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntemler: Bu retrospektif, tek merkezli çalışmaya, DEHB tanısı almış 67 çocuk ve ergen ile yaş ve cinsiyet açısından eşleştirilmiş 75 sağlıklı kontrol dahil edilmiştir. Tıbbi kayıtlar incelenerek hemogram ve lipid paneli parametreleri değerlendirilmiş ve her katılımcı için MHR hesaplanmıştır. Monosit düzeyleri, HDL seviyeleri ve MHR değerleri DEHB ve kontrol grupları arasında karşılaştırılmıştır.
Bulgular: DEHB grubunda monosit seviyeleri kontrol grubuna kıyasla anlamlı derecede yüksek bulunmuştur (p = 0,028). Ancak, gruplar arasında HDL seviyeleri (p = 0,783) veya MHR (p = 0,076) açısından anlamlı bir fark saptanmamıştır.
Sonuç:Bulgular, sistemik inflamasyonun, yüksek monosit düzeyleriyle gösterildiği gibi, DEHB'nin patofizyolojisine katkıda bulunabileceğini düşündürmektedir. Ancak, MHR’de anlamlı bir farkın olmaması, lipid metabolizması değişikliklerinin DEHB ile ilişkili inflamasyonda birincil bir rol oynamayabileceğini göstermektedir. DEHB'de immün disregülasyonun rolünü açıklığa kavuşturmak için daha büyük örneklem ve daha fazla sayıda inflamatuar belirtecin değerlendirildiği daha fazla çalışmaya ihtiyaç vardır.

Keywords

DEHB , inflamasyon , Monosit/HDL oranı , bağışıklık sistemi , lipid metabolizması

Monocyte/High Density Lipoprotein (HDL) Ratio in Children and Adolescents with Attention Deficit Hyperactivity Disorder

Abstract

Purpose: Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. Recent studies suggests that immune dysregulation and inflammation may play a role in its pathophysiology. The monocyte-to-high-density lipoprotein (HDL) ratio (MHR) has been proposed as a novel inflammatory marker. This study aimed to investigate the relationship between ADHD and MHR.
Material and Methods: This retrospective, single-center study included 67 children and adolescents diagnosed with ADHD and 75 age- and sex-matched healthy controls. Hemogram and lipid panel parameters were retrieved from medical records, and MHR was calculated for each participant. Monocyte levels, HDL levels, and MHR values were compared between the ADHD and control groups.
Results: Monocyte levels were significantly higher in the ADHD group compared to the controls (p = 0.028). However, no significant differences were found between the groups in terms of HDL levels (p = 0.783) or MHR (p = 0.076).
Conclusions: The findings suggest that systemic inflammation may contribute to the pathophysiology of ADHD, as indicated by elevated monocyte levels. However, the lack of a significant difference in MHR suggests that lipid metabolism alterations may not play a primary role in ADHD-related inflammation. Further studies with larger samples and more inflammatory markers are needed to clarify the role of immune dysregulation in ADHD.

Keywords

ADHD , inflammation , monocyte -to -HDL ratio , immune system , lipid metabolism

Ethical Statement

Ethical approval was obtained from the Aksaray University Faculty of Medicine Non-Interventional Clinical Research Ethics Committee dated 26.12.2024 and numbered 2024/172. Our research was conducted in accordance with the World Medical Association Helsinki Declaration Ethical Principles.

Supporting Institution

The authors did not receive support from any organization for the submitted work.

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