Bisphosphonate Related Osteonecrosis Of The Jaws(Bronj) And The Current Treatment Modalities

Abstract

Recently bisphosphonates are widely used for treatment of many bone metabolism related disease and cancer treatment. There are lots of case reports and studies concerned with the jaw bone osteonecrosis which depends on long term use of the bisphosphonates. However, the role of bisphosphonates in the etiology of osteonecrosis is still unclear. The purpose of this report is giving broadly information about the chemical structures of bisphosphonates, mechanisms of action, radiogaphic findings, complications and current treatment modalities. Actual prevention methods of the osteonecrosis are also discussed.

Keywords

• Bisphosphonate, bone, necrosis, treatment

Bisfosfonatlara Bağlı Olarak Çene Kemiklerinde Gelişen Osteonekroz (Bon) ve Güncel Tedavi Yöntemleri

Abstract

Bisfosfonatlar günümüzde kemik metabolizmasıyla ve kanser tedavisi ile ilgili çok sayıda hastalığın tedavisinde yaygın olarak kullanılmaktadır. İlacın uzun süre kullanımına bağlı çene kemiklerinde oluşan osteonekrozla ilişkili bir çok vaka raporu ve çalışma mevcut olmasına rağmen ilacın osteonekrozun etiyolojisinde nasıl bir rol oynadığı hala tam olarak açıklanamamıştır. Bu çalışmada bisfosfonatların kimyasal yapıları, etki mekanizmaları, radyolojik bulguları, kullanımına bağlı ortaya çıkan komplikasyonlar ve osteonekrozun oluşmasını önlemeye yönelik yapılması gerekenler ve güncel tedavi yaklaşımı hakkında bilgi verilecektir.

Keywords

• Anahtar Kelimler: Bisfosfonat, kemik, nekroz, tedavi

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47. Yrd. Doç. Dr. İsmail Doruk KOÇYİĞİT Kırıkkale Üniversitesi Diş Hekimliği Fak. Ağız, Diş ve Çene Cerrahisi A.D Kırıkkale Merkez Tel: [phone] e-Mail: [e-mail]