The Effect On Alveolar Bone Loss Of Long-Term Phenytoin Use İn The Treatment Of Epilepsy

Abstract

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Keywords

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Epilepsi Tedavisinde Uzun Dönem Fenitoin Kullanımının Alveolar Kemik Kaybı Üzerine Etkisi

Abstract

Amaç: Epilepsi tedavisinde sıklıkla kullanılan eski nesil antiepileptik ilaçlardan birisi olan fenitoinin diş eti büyümesi ve kemik metabolizmasında değişiklikler gibi bir takım yan etkileri bulunmaktadır. Bu çalışmanın amacı epilepsi hastalarında uzun dönem fenitoin kullanımı ve alveolar kemik kaybı arasındaki ilişkiyi değerlendirmekti. Gereç ve Yöntem: Bu çalışma fenitoin (PHT) kullanan epileptik (n=65) ve PHT kullanmayan epileptik olmayan (kontrol grubu, n=65) toplam 130 birey üzerinde yapıldı. Periodontal değerlendirme için plak indeksi (Pİ), sondlama derinliği (SD), sondlamada kanama (SK) ve klinik ataçman düzeyi (KAD) ölçüldü. Kemik miktarını değerlendirmek için ise panoramik ve periapikal radyografiler kullanıldı. Bulgular: PHT kullanan grup ile kontrol grubu arasında Pİ, SK, SD değerleri benzer bulundu (p>0.05). Ayrıca iki grup arasında ortalama KAD’lerinin, KAD>4 mm bölgelerin yüzdesinin, kemik kaybı yüzdelerinin ve DMFT skorlarının da istatistiksel olarak farklı olmadığı görüldü (p>0.05). Kemik kayıplarının periodontal parametrelerle ilişkili olduğu görülürken (p0.05). Sonuç: Bu çalışmanın bulguları PHT kullanımının alveolar kemik yıkımını artırabileceğini desteklememektedir

Keywords

• Epilepsi, fenitoin, periodontal hastalık, alveolar kemik kaybı

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