BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAWS: ETIOLOGY, RISK FACTORS, DIAGNOSTIC CRITERIA, TREATMENT ALTERNATIVES

Abstract

Bisphosphonates are synthetic analogues of pyrophosphates used for the treatment of hypercalcemia in patients with malignancies and bone metastasis and for the treatment of multiple myeloma, bone resorption in the case of metastatic malignant diseases, and in the treatment of osteoporosis. Even though their application has shown to be effective in reducing pain and minimizing the risk of skeletalrelated events, their administration may also bring adverse events such as osteonecrosis of the jaws. Since the end of 2003, several reports have been published on jaw osteonecrosis possibly being associated with the administration of bisphosphonates. The aim of the present review was to analyze the etiology, clinical manifestations, risk factors, radiologic features and different treatment strategies of bisphosphonate-associated osteonecrosis of the jaws.

Keywords

• Bisphosphonate
• Osteonecrosis
• Alveolar bone

BİSFOSFANAT KULLANIMINA BAĞLI ÇENE KEMİĞİNDE GELİŞEN OSTEONEKROZ: ETYOLOJİ, RİSK FAKTÖRLERİ, TANI KRİTERLERİ VE TEDAVİ ALTERNATİFLERİ

Abstract

Bisfosfanatlar pirofosfatların sentetik analogları olup; malignensilere bağlı olarak gelişen hiperkalsemi, multipl myeloma, kemik metastazı tedavisin yanında osteoporöz tedavisi için kullanılan ilaçlardır. İlacın uygulanması iskeletsel anomalilere bağlı olarak gelişen riskleri minimuma indirerek ağrı kontrolünü sağlasa da, ilacın kullanımına bağlı olarak çene kemiklerinde gelişen osteonekroz gibi yan etkileri de görülebilmektedir. 2003 yılının sonlarından itibaren, bu konuda bildirilen olgu sayısı hızla artış göstermiştir. Bu derlemenin amacı bisfosfanat kullanıma bağlı olarak çene kemiklerinde gelişen osteonekroz olgularının etiyolojisini, klinik ve radyolojik bulgularını, risk faktörlerini ve farklı tedavi seçeneklerini irdelemektir

Keywords

• Bisfosfanat
• Osteonekroz
• Alveol kemiği

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