PERIODONTAL REGENERATION AND GROWTH FACTORS

Abstract

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Keywords

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PERİODONTAL REJENERASYON VE BÜYÜME FAKTÖRLERİ

Abstract

Periodontal rejeneratif i lemler, inflamasyon nedeniyle y k ma u1ram di eti ba1 dokusunun rejenerasyonunu, sement formasyonunu, y k lan kemi1in restorasyonunu ve kök yüzeyine periodontal ata man n yeniden oryante olmas n hedefler. Bununla beraber hastal kl periodonsiyumun önceden belirlenen bir ekilde ve tam rejenerasyonunun sa1lanmasoldukça zordur. Periodontal rejenerasyon için gerekli olaylar kemik olu umu, sement olu umu ve ba1dokusu olu umu üzerine kuruludur. &n vitro ve in vivo olarak yap lm çal malarla baz büyüme faktörlerinin periodontal yara iyile mesinde ve s n rl da olsa periodontal rejenerasyonda olumlu etkileri gösterilmi tir. Bu nedenle, derlemede periodontal rejenerasyonda önemli rol oynad 1 dü ünülen büyüme faktörleri irdelenmi tir

Keywords

• periodontal rejenerasyon, büyüme faktörleri, periodontal ligament, fibroblastlar, osteoblastlar

References

1. Caffesse R, Quinones CR. Polypeptide growth factors and attachment proteins in periodontal wound healing and regeneration. Periodontol 2000 1993; 1: 69-79.
2. Amar S. Implications of cellular and molecular biology advances in periodontal regeneration. Anat Rec 1996; 245: 361-373.
3. Caton JG, Greenstein G. Factors related to periodontal regeneration. Periodontol 2000 1993; 1:9-15.
4. McCauley LK, Somerman MJ. Biologic modifiers in periodontal regeneration. Dental Clinics of North America 1998; 42 part I: 361-386.
5. Bartold PM, Narayanan AS. Biology of the periodontal connective tissues. Quintessence Pubkishing Co,Inc.1998: 93-120.
6. Karring T, Lindhe J, Cortellini P. Clinical periodontology and implant dentistry. Copenhagen: Munksgaard. 1997: 707-714.
7. Callens A. Growth factors in periodontal regeneration. In: Chemicals in Periodontics. Eds, Lang&Karring Lindhe, 1998.pp.284-302.
8. Cochran DL, Wozney JM. Biologic mediators for periodontal regeneration. Periodontol 2000 1999;19:40-58.

9. Sayg n NE, Giannobile WV, Somerman MJ. Mole- cular and cell biology of cementum. Periodontol 2000 2000; 24: 73-98.
10. Grezesik WJ, Narayanan AS. Cementum and periodontal wound healing and regeneration. Crit Rev Oral Biol Med 2002; 13:474-484.
11. Foster BL, Somerman MJ. Regenerating the periodontium: is there a magic Formula? Orthod Craniofacial Res 2005; 8: 285-291.
12. Sodek J, McKee MD. Molecular and cellular biology of alveolar bone. Periodontology 2000 2000; 24: 99-126.
13. Hease HR, Bartold PM. Enamel matrix derivative induces matrix synthesis by cultured human periodontal fibroblast cells. J Periodontol 2001;72: 341-348.
14. Graves DT. The use of biologic response modifiers in human clinical trials. Ann Periodontol 1997; 2: 259-267.
15. Lang H, Schuler N, Arnhold S, Nolden R, Mertens T. Formation of differantiated tissues in vitro by periodontal cell populations cultured in vitro. J Dent Res 1995; 74: 1219-1225.
16. Saito S, Rosol TJ, Saito M, Ngan PW, Shanfeld J, Davidovitch Z. Bone-resorbing activity and prostoglandin E produced by human periodontal ligament cells in vitro. J Bone Miner Res 1990; 5: 1013-1018.
17. MacNeil RL, Somerman MJ. Developement and regeneration of the periodontium: parallels and contrasts. Periodontol 2000 1999; 19: 8-20.
18. Osborn JW, Price DG. An autoradiographic study of periodontal development in the mouse. J Dent Res 1988; 67:455.
19. Palmer RM, Lumsden AGS. Development of periodontal ligament and alveolar bone in homografted recombinations of enamel organs and papillary, pulpal and follicular mesenchyme in the mouse. Arch Oral Biol 1987;32:281.
20. Yoshikawa DK, Kollar EJ. Recombination experiments on the odontogenic roles of Mouse dental papilla and dental sac tissues in ocular grafts. Arch Oral Biol 1981; 26: 303-307.
21. Gionnobile WV, Somerman MJ. Growth and amelogenin-like factors in periodontal wound healing. A systematic review. Ann Periodontol 2003; 8: 193-204.
22. Nohutçu RM, McCauley LK, Shigeyama Y, Somerman MJ. Expression of mineral-associated proteins by periodontal ligament cells: in vitro vs. ex vivo. J Periodontal Res 1996: 31; 369-372.
23. Roberts WE, Wood HB, Chambers DW, Burk DT. Vascularly oriented differentiation gradient of osteoblast precursor cells in rat periodontal ligament: implications for osteoblast histogenesis and periodontal lost. J Periodontal Res 1987;22: 461-467.
24. Zhao M, Xiao G, Berry JE, Franceshi RT, Reddi A, Somerman MJ. Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res 2002; 18: 1441-1451.
25. D’Errico JA, MacNeil RL, Takata T, Berry J, Strayhorn X, Somerman MJ. Expression of bone associated markers by tooth root lining cells, insitu and in vitro. Bone 1997; 20: 117-126.
26. Garret S. Periodontal regeneration around natural teeth. Ann Periodontol 1996; 1: 621-666.
27. Taba Jr M, Jin Q, Sugai JV, Giannobile WV. Current concepts in periodontal regeneration. Orthod Craniofacial Res 2005; 8: 292-302.
28. Schroeder HE, Lisgarten MA. The gingival tissues: architecture of periodontal protection. Periodontol 2000 1997; 13: 91-120.
29. Nohutcu RM, Somerman MJ, McCauley LK. Dexamethasone enhances the effects of parathyroid hormone(PTH) on human periodontal ligament(PDL) cells in vitro. Calcif Tissue Int 1995; 56: 571-577
30. Graves DT, Cochran DL. Mesenchymal cell growth factors. Critical Review of Oral and Biological Medicine 1990 ;1:17-36.
31. Parker MH, Kuru L, Giouzeli M, Olsen I. Expression of growth-factor receptors in normal and regenerating human periodontal cells. Arch Oral Biol 2001; 46: 275-284.
32. Nemato E, Kanaya S, Minamibuchi M, Shimauchi. Cleavage of PDGF receptor on periodontal ligament cells by elastase. J Dent Res 2005;84: 629-633.
33. Position Paper. The potential role of growth and differentiation factors in periodontal regeneration. J Periodontol 1996; 67: 545-553.
34. Rutherford RB, Trailsmith MD, Ryan ME, Charette MF. Synergistic effects of dexamethasone on platelet derived growth factor mitogenesis in vitro. Arch Oral Biol 1992; 37: 139-145.
35. Matsuda N, Lin WL, Kumar NM, Cho MI, Genco RJ. Mitogenic, chemotactic and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. J Periodontol 1992; 63: 515-525.
36. Graves DT, Valentin-Opran A, Delgado R, Valente AJ, Mundy G, Piche J. The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. Connect Tissue Res 1989; 23: 209-218.
37. Canalis E, McCarthy TL, Centrella M. Effects of platelet-derived growth factor on bone formation in vitro. J Cell Physiol 1989; 140: 530-537.
38. Centrella M, McCarthy TL, Kusmik WF, Canalis E. Relative binding and biochemical effects of heterodimeric and homodimeric isoforms of platelet-derived growth factor in osteoblast- enriched cultures from fetal rat bone. J Cell Physiol 1991; 147:420-426.
39. Oates TW, Rouse CA, Cochran DL. Mitogenic effects of growth factors on human periodontal ligament cells in vivo. J Periodontol 1993; 64: 142-148.
40. Zhang L, Leeman E, Carnes DC, Graves DT. Human osteoblasts synthesize and respond to platelet derived growth factor. Am J Physiol 1991; 261:C 348-354.
41. Hughes FJ, Aubin JE, Heersche JN. Differential chemotactic responses of different populations of fetal rat calvaria cells to platelet derived growth factor and transforming growth factor beta. Bone Miner 1992; 19: 63-74.
42. Boyan LA, Bhargava G, Nishimura F, Orman R, Price R, Terranova VP. Mitogenic and chemotactic responses of human periodontal ligament cells to the different isoforms of platelet derived growth factor. J Dent Res 1994;73: 1593-1600.
43. Carlson NE, Roach RB. Plataet-rich plasma: Clinical applications in dentistry. JADA 2002; 133: 1383- 1386.
44. Cerutis DR, Dreyer AC, Vierra MJ, King JP, Wagner DJ, Fimple JL, Cordini F,McVaney TP, Parrish LC, Wilwerding TM, Mattson JS. Lysophosphatidic Acid Modulates the Healing Responses of Human Periodontal Ligament Fibroblasts and Enhances the Actions of Platelet-Derived Growth Factor. J Periodontol. 2007; 78 : 1136-1145.
45. Han J, Meng HX, Tang JM, Li SL, Tang Y, Chen ZB. The effect of different platelet-rich plasma concentrations on proliferation and differentiation of human periodontal ligament cells in vitro. Cell Prolif. 2007; 40: 241-52.
46. Chung CP, Kim DK, Park YJ, Nam KH, Lee SJ. Biological effects of drug-loaded biodegradable membranes for guided bone regeneration. J Periodontal Res 1997; 32: 172-175.
47. Park JB, Matsuura M, Han KY, Norderyd O, Lin WL, Genco RJ, Cho MI. Periodontal regeneration in class III furcation defects of beagle dogs using guided tissue regenerative therapy with platelet derived growth factor. J Periodontol 1995; 66: 462-477.
48. Zhang Y, Wang Y, Shi B, Cheng X. A platelet- derived growth factor releasing chitosan/coral composite scaffold for periodontal tissue engineering. Biomaterials 2007; 28:1515-22.
49. Baylink DJ, Finkelman RD, Mohan S. Growth factors to stimulate bone formation. J Bone Miner Res 1993;8: S565-S572.
50. Schmid C. The regulation of osteoblast function by hormones and cytokines with special reference to insulin-like growth factors and their binding proteins. J Intern Med 1993; 234: 535-542.
51. Daughaday WH, Rowein P. Insuline-like growth factors I and II. Peptide, Messenger ribonucleic acid and gene structures, serum and tissue concentrations. Endocr Rev 1989; 10: 68-91.
52. Shimasaki S, Ling N. Identification and molecular characterization of insuline-like growth factor binding proteins (IGFBP-1,-2,-3,-4,-5 and-6). Prog Growth Factor Res 1991; 3: 243-266.
53. Mohan S, Baylink DJ. Bone growth factors. Clin Orthop 1991; 263: 30-48.
54. Canalis E, Pash J, Gabbitas B, Rydziel S, Varghese S. Growth factors regulate the synthesis of insuline-like growth factor-I in bone cell cultures. Endocrinology 1993; 133: 33-38.
55. Canalis E. Effect of insuline like growth factor-I on DNA synthesis in cultured rat calvaria. J Clin Invest 1980; 66: 709-719.
56. Canalis E, McCarthy T, Centrella M. Isolation and characterization of insuline like growth factor-I (somatedin C) from cultures of fetal rat calvaria. Endocrinology 1988; 122: 22-27.
57. Hock JM, Centrella M, Canalis E. Insuline like growth factor-I has independent effects on bone matrix formation and replication. Endocrinology 1988; 122: 22-27.
58. Mohan s, Linkhart T, Jennings J, Baylink D. Chemical and biological characterization of low- molacular weight skeletal growth factor from human bones. Biochem Biophys Acta 1986; 884: 243-250.
59. Cho MI, Lin WL, Garant PR. Occurence of epidermal growth factor-binding sites during differentiation of cementoblasts and periodontal ligament fibroblasts of young rat:a light and electron microscopic radioautographic study. Anat Rec 1991; 231: 14-24.
60. Götz W, Kunert D, Zhang D, Kawarizahen A, Lossdörfer S,Jager A. Insuline-like growth factor system components in periodontium during tooth root resorption and early repair processes in the rat. Eur J Oral Sci 2006;114: 318-327.
61. Dennison DK, Vallone DR, Pinero GJ, Rittman B, Caffesse RG. Differetial effect of TGF- 1 and PDGF on proliferation of periodontal ligament cells and gingival fibroblasts. J Periodontol 1994; 65: 641-648.
62. Selvig KA, Wikesjö UME, Bogle GC, Finkelmann RD. Impaired early bone formation in periodontal fenestration defects in dogs following application of insuline-like growth factor II, basic fibroblast growth factor and transforming growth factor beta1. j Clin Periodontol 1994; 21: 380-385.
63. Rutherford RB, Sampath TK, Rueger DC, Taylor TD. Use of bovine osteogenic protein to promote rapid osseointegration of endosseous dental implants. Int J Oral Maxillofacial Implants 1992; 7: 297-301.
64. Lynch SE, Williams RC, Polson AM, Howell TH, Reddy MS, Zappa UE, Antoniades HN. A combina- tion of platelet derived and insuline like growth factors enhances periodontal regeneration. J Clin Periodontol 1989;16: 545-548.
65. Stefani CM, Machado MA, Sallum EA, Toledo S, Nociti FH Jr. Platelet-derived growth factor/ Insuline-like growth factor-I combination and bone regeneration around implants placed into extraction sockets: a histometric study in dogs. Implant Dent 2000; 9: 126-131.
66. Tözüm TF, Demiralp B. Platelet-rich plasma: A promising innovation in dentistry. J Can Dent assoc 2003; 69: 664.
67. Terranova VP, Odziemiec C, Tweden KS, Spadone DP. Repopulation of dentin surfaces by periodontal ligament cells and endothelial cells. Effect of basic fibroblast growth factor. J Periodontol 1989; 60: 293-301.
68. Tweden KS, Spadone DP, Terranova VP. Neovascularization of surface demineralized dentin. J Periodontol 1989; 60: 460-466.
69. Canalis E, McCarthy T, Centrella M. Effects of basib fibroblast growth factor on bone formation in vitro. J Clin Invest 1988; 81: 1572-1577.
70. Hauschka PV, Mavrakos AE; Isafrati MD, Doleman SE, Klagsburn M. Growth factors in bone matrix isolation of multiple types by affinity chromatography on heparin-septanose. J Biol Chem 1986; 261: 12665-12674.
71. Globus RK, Plouet J, Gospodarowicz D. Cultured bovine osteoblasts synthesize basic fibroblast growth factor and store it in their extracellular matrix. Endocrinology 1989; 124: 1539-1547.
72. Jingushi S, Heydemann a, Kana SK, Macey LR, Bolander ME. Acidic fibroblast growth factor injection stimulates cartilage enlargement and inhibits cartilage gene expression in rat fracture healing. J Orthop Res 1990; 8: 364-371.
73. Schüppbach P, Gaberthüel T, Lutz F, Guggenheim B. Periodontal repair or regeneration: structures of different types of new attachment. J Periodontal Res 1993; 28: 281-293.
74. Murakami S, Takayama S, Kitamura M, Shimabukuro Y, Yanagi K, Ikezewa K, Saho T, Nozaki T, Okada H. Recombinant human basic fibroblast growth factor stimulates periodontal regeneration in class II furcation defects created in beagle dogs. J Periodontal Res 2003; 38: 97- 103.
75. Takayama S, Murakami S, Shimabukuro Y, Kitamura M, Okada H. Periodontal regeneration by FGF-2 (bFGF) in primate models. J Dent Res 2001; 80: 2075-2079.
76. Murakami S, Takayama S, Ikezewa K, Shimabukuro Y, Kitamura M, Nozaki T, Terashima A, Asano T, Okada H. Regeneration of periodontal tissues by basic fibroblast growth factor. J Periodontal Res 1999; 34: 425-430.
77. Shimabukuro Y, Ich kawa T, Takayama S, Yamada S, Takedachi M, Terakura M, Hashikawa T, Murakami S. Fibroblast growth factor-2 regulates the synthesis of hyaluronan by human periodontal ligament cells. J Cell Physiol 2005; 203: 557-563.
78. Bonewald LF, Mundy GR. Role of transforming growth factor- in bone remodeling. Clin Orthop 1990; 250: 261-276.
79. De Ranieri A, Virdi AS, Kurado S, Shott S, Leven RM, Hallab NJ et al. Local application of rhTGF- beta2 enhances peri-implant bone volume and bone-implant contact in a rat model. Bone 2005; 37: 55-62.
80. DeCarlo AA, Whitelock JM. The role of heparan sulfate and perlecan in bone-regenerative procedures. J Dent Res 2006; 85: 122-132.
81. Zohar R, Tenenbaum HC. How predictable are periodontal regenerative procedures. J Can Dent Assoc 2005; 71: 675-680.
82. Centrella M, McCarthy T, Canalis E. Transforming growth factor beta is a bifunctional regulator of replivcation and collagen synthesis in osteoblast- enriched cell cultures from fetal rat bone. J Biol Chem 1987; 262: 2869-2874.
83. Rodrigues TL, Marchesan JT, Coletta RD, Novaes AB Jr, Grisi MF, Souza SL, Taba M Jr, Palioto DB. Effects of enamel matrix derivative and transfor- ming growth factor-beta1 on human periodontal ligament fibroblasts. J Clin Periodontol. 2007; 34: 514-22.
84. Csiszar A, Wiebe C, Larjava H, Hakkinen L. Distinctive molecular composition of human gingi- val interdental papilla. J Periodontol. 2007;78: 304-14.
85. Lynch SE, Colvin RB, Antoniades HN. Growth factors in wound healing: Synergistic effects with other growth factors. J Clin Invest 1989; 84: 640- 646.
86. Kawase T, Okuda K, Yoshie H, Burns DM. Anti- TGF-Beta antibody blocks enamel matrix derivative-induced upregulation of p21WAF1/cip1 and prevents its inhibition of human oral epithelial cell proliferation. J Periodontal Res 2002; 37: 255- 262.
87. Hong L, Tabata Y, Miyamoto S, Yamada K, Aoyama I, Tamura M. Promoted bone healing at rabbit skull gap between autologous bone fragment and the surrounding intact bone with biodegradable microspheres containing transfor- ming growth factor-beta1. Tissue Eng 2000; 6:331-340.
88. Nakae H, Narayanan S, Raines E, Page RC. Isolation and partial characterization of mitogenic factors from cementum. Biochemistry 1991; 30: 7047-7052.
89. Naryanan SA, Yonemura K. Purification and characterization of a novel growth factor from cementum. Journal of periodontal research 1993; 28: 563-565.
90. Yonemura K, Narayanan SA, Miki Y, Page RC, Okada H. Isolation and partial characterization of growth factor from human cementum. Bone Miner 1992; 18: 187-198.
91. Feliciani C, Gupta AK, Sauder DN. Keratinocytes and cytokine/growth factors. Crit Rev Oral Biol Med 1996; 7: 300.
92. Ripamonti U. Recapitulating developement: a template for periodontal tissue engineering. Tissue Engineering 2007; 13: 51-71.
93. Ikada Y. Challenges in tissue engineering. J R Soc Interface 2006; 3: 589-601.
94. Lee MB. Bone Morphogenetic Proteins: background and implications for oral reconstruction :a review. J Clin Periodol 1997; 24: 355-365.
95. Wozney JM. The potential role of BMP in periodontal reconstruction. J Periodontol 1995; 66: 506-510.
96. Ripamonti U, Reddi AH. Review article: Periodontal regeneration: potential role of bone morphogenetic proteins. J Period Res 1994; 29: 225-235.
97. Wang X, Jin Y, Liu B, Zhou S, Yang L, Xi Y, White FH. Tissue reactions to tinium implants containing bovine bone morphogenetic protein: a scanning electron microscopic investigation. Int J Oral Maxillofac Surg 1994; 23: 115-119.
98. Reddi AH, Cunningham NS. Initiation and promotion of bone differentiation by bone morphogenetic proteins. J Bone Miner Res 1993; 8(suppl 2): s499-s502. Yaz81ma adresi: Dt. Müge Lütfio;lu Ondokuz May s Üniversitesi Periodontoloji A.D. Di hekimli1i Fakültesi 55139-Kurupelit Samsun Tel:[phone] - 3021 Faks:0 362 4576032 e-mail:[e-mail]