Case Report
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SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU

Year 2014, Volume: 24 Issue: Supplement 8, 18 - 22, 11.02.2015
https://doi.org/10.17567/dfd.67582

Abstract

Organ transplantasyonlarında kullanılan temel bir immünosüpresan olan siklosporin-A (Cs-A) ve antihipertansif amlodipinin kullanımına bağlı oral komplikasyonlar gelişebilmektedir. Bu komplikasyon- ların en yaygın olanlarından biri dişeti büyümeleridir. Bu olgu, böbrek transplantasyonu nedeni ile uzun dönem Cs-A ve amplodipin kullanımı sonucu dişeti büyüme şikayeti gelişen bir hastanın tedavi öncesi ve sonrası klinik durumunu ortaya koymaktadır. Sunulan vakada aşırı büyüyen dişeti dokularında Nd: YAG lazerle yapılan cerrahi işlemi takiben dikkatli plak kontrolü ile dişeti dokusunda yeterli ölçüde iyileşme sağlanmıştır. Cerrahide Nd: YAG lazer kullanımı cerrahi sonrası gelişebilen kanama, ağrı gibi komplikasyonları azaltmıştır.

References

  • Lafzi A, Farahani RM, Shoja MA. Amlodipine- induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal,2006, 11: E480-2.
  • Eggerath J, English H, Leichter JW. Drug- associated gingival enlargement: case report and review of aetiology, management and evidence- based outcomes of treatment. J N Z Soc Periodontol,2005: 7-14.
  • Kara c, Yağız H, Zihni M. Nifedipin tedavisine bağlı ortaya çıkan dişeti büyümesi (Olgu Sunumu). Atatürk Üni Diş Hek Fak Derg 2006;16(1):59-62.
  • Callaghan CJ, Bradley JA. Current status of renal transplantation. Methods Mol Biol,2006, 333: 1- 28.
  • Gourishankar S, Halloran PF. Late deterioration of organ transplants: a problem in injury and homeostasis. Curr Opin Immunol,2002, 14: 576- 83.
  • Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med,2000, 342: 605-12.
  • Lopez-Pintor RM, Hernandez G, de Arriba L, Morales JM, Jimenez C, de Andres A. Amlodipine and nifedipine used with cyclosporine induce different effects on gingival enlargement. Transplant Proc,2009, 41: 2351-3.
  • Seymour RA, Ellis JS, Thomason JM, Monkman S, Idle JR. Amlodipine-induced gingival overgrowth. J Clin Periodontol,1994, 21: 281-3.
  • Camargo PM CF, Takei HH. , Treatment of gingival enlargement. 11 ed.; St. Louis, Missouri, 2011; p 556-61.
  • Mattson JS, Blankenau R, Keene JJ. Use of an argon laser to treat drug-induced gingival overgrowth. The Journal of the American Dental Association,1998, 129: 78-83.
  • Loe H, Silness J. Periodontal Disease in Pregnancy. I. Prevalence and Severity. Acta Odontol Scand, 1963, 21: 533-51.
  • Silness J, Loe H. Periodontal Disease in Pregnancy. Ii. Correlation between Oral Hygiene and Periodontal Condtion. Acta Odontol Scand,1964, 22: 121-35.
  • Radwan-Oczko M, Boratynska M, Klinger M, Zietek M. Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A. Ann Transplant,2003, 8: 57-62.
  • Hernandez G, Arriba L, Frias MC, de la Macorra JC, de Vicente JC, Jimenez C, de Andres A, Moreno E. Conversion from cyclosporin A to tacrolimus as a non-surgical alternative to reduce gingival enlargement: a preliminary case series. Periodontol,2003, 74: 1816-23. J
  • Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol,1999, 70: 63-7.
  • Jorgensen MG. Prevalence of amlodipine-related gingival hyperplasia. J Periodontol,1997, 68: 676- 8.
  • Ellis JS, Seymour RA, Thomason JM, Monkman SC, Idle JR. Gingival sequestration of amlodipine and amlodipine-induced gingival overgrowth. Lancet, 1993, 341: 1102-3.
  • Lin YT, Yang FT. Gingival enlargement in children cyclosporine transplantation. J Periodontol,2010, 81: 1250-5.
  • Thomas DW, Newcombe RG, Osborne GR. Risk factors in the development of cyclosporine-induced gingival overgrowth. Transplantation,2000, 69: 522-6.
  • Nurmenniemi PK, Pernu HE, Laukkanen P, Knuuttila ML. Macrophage subpopulations in gingival overgrowth induced by nifedipine and immunosuppressive medication. J Periodontol, 2002, 73: 1323-30.
  • Lima RB, Benini V, Sens YA. Gingival overgrowth in renal transplant recipients: a study concerning prevalence, severity, periodontal, and predisposing factors. Transplant Proc,2008, 40: 1425-8.
  • Aimetti M, Romano F, Priotto P, Debernardi C. Non-surgical periodontal therapy of cyclosporin A gingival overgrowth in organ transplant patients. Clinical results at 12 months. Minerva Stomatol, 2005, 54: 311-9.
  • Darbar UR, Hopper C, Speight PM, Newman HN. Combined treatment approach to gingival overgrowth due to drug therapy. Periodontol,1996, 23: 941-4. J Clin
  • Kara C. Evaluation of patient perceptions of frenectomy: a comparison of Nd:YAG laser and conventional techniques. Photomed Laser Surg, 2008, 26: 147-52.
  • Pogrel MA, Yen CK, Hansen LS. A comparison of carbon dioxide laser, liquid nitrogen cryosurgery, and scalpel wounds in healing. Oral Surg Oral Med Oral Pathol,1990, 69: 269-73.
  • White JM, Goodis HE, Rose CL. Use of the pulsed Nd:YAG laser for intraoral soft tissue surgery. Lasers Surg Med,1991, 11: 455-61.

TREATMENT OF CYCLOSPORIN A AND AMLODIPINE INDUCED GINGIVAL OVERGROWTH WITH ND:YAG LASER ( CASE REPORT)

Year 2014, Volume: 24 Issue: Supplement 8, 18 - 22, 11.02.2015
https://doi.org/10.17567/dfd.67582

Abstract

Oral complications may develop due to use of immunosuppresantcyclosporine-A (Cs-A), which is basic drug in organ transplantation, and antihypertensive amlodipine. One of the most common of these complications is gingival overgrowth. This case demonstrates clinical status of a patient before and after the treatment, who has developing gingival overgrowth complaint after long-term use of amlodipine transplantation. In the presented case, sufficient improvement of gingival tissues was provided by careful plaque control following surgical procedures with Nd: YAG laser in excessive gingival overgrowth tissues. Rising complications after surgical operations such as bleeding and pain can decrease by use of Nd: YAG laser

References

  • Lafzi A, Farahani RM, Shoja MA. Amlodipine- induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal,2006, 11: E480-2.
  • Eggerath J, English H, Leichter JW. Drug- associated gingival enlargement: case report and review of aetiology, management and evidence- based outcomes of treatment. J N Z Soc Periodontol,2005: 7-14.
  • Kara c, Yağız H, Zihni M. Nifedipin tedavisine bağlı ortaya çıkan dişeti büyümesi (Olgu Sunumu). Atatürk Üni Diş Hek Fak Derg 2006;16(1):59-62.
  • Callaghan CJ, Bradley JA. Current status of renal transplantation. Methods Mol Biol,2006, 333: 1- 28.
  • Gourishankar S, Halloran PF. Late deterioration of organ transplants: a problem in injury and homeostasis. Curr Opin Immunol,2002, 14: 576- 83.
  • Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med,2000, 342: 605-12.
  • Lopez-Pintor RM, Hernandez G, de Arriba L, Morales JM, Jimenez C, de Andres A. Amlodipine and nifedipine used with cyclosporine induce different effects on gingival enlargement. Transplant Proc,2009, 41: 2351-3.
  • Seymour RA, Ellis JS, Thomason JM, Monkman S, Idle JR. Amlodipine-induced gingival overgrowth. J Clin Periodontol,1994, 21: 281-3.
  • Camargo PM CF, Takei HH. , Treatment of gingival enlargement. 11 ed.; St. Louis, Missouri, 2011; p 556-61.
  • Mattson JS, Blankenau R, Keene JJ. Use of an argon laser to treat drug-induced gingival overgrowth. The Journal of the American Dental Association,1998, 129: 78-83.
  • Loe H, Silness J. Periodontal Disease in Pregnancy. I. Prevalence and Severity. Acta Odontol Scand, 1963, 21: 533-51.
  • Silness J, Loe H. Periodontal Disease in Pregnancy. Ii. Correlation between Oral Hygiene and Periodontal Condtion. Acta Odontol Scand,1964, 22: 121-35.
  • Radwan-Oczko M, Boratynska M, Klinger M, Zietek M. Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A. Ann Transplant,2003, 8: 57-62.
  • Hernandez G, Arriba L, Frias MC, de la Macorra JC, de Vicente JC, Jimenez C, de Andres A, Moreno E. Conversion from cyclosporin A to tacrolimus as a non-surgical alternative to reduce gingival enlargement: a preliminary case series. Periodontol,2003, 74: 1816-23. J
  • Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol,1999, 70: 63-7.
  • Jorgensen MG. Prevalence of amlodipine-related gingival hyperplasia. J Periodontol,1997, 68: 676- 8.
  • Ellis JS, Seymour RA, Thomason JM, Monkman SC, Idle JR. Gingival sequestration of amlodipine and amlodipine-induced gingival overgrowth. Lancet, 1993, 341: 1102-3.
  • Lin YT, Yang FT. Gingival enlargement in children cyclosporine transplantation. J Periodontol,2010, 81: 1250-5.
  • Thomas DW, Newcombe RG, Osborne GR. Risk factors in the development of cyclosporine-induced gingival overgrowth. Transplantation,2000, 69: 522-6.
  • Nurmenniemi PK, Pernu HE, Laukkanen P, Knuuttila ML. Macrophage subpopulations in gingival overgrowth induced by nifedipine and immunosuppressive medication. J Periodontol, 2002, 73: 1323-30.
  • Lima RB, Benini V, Sens YA. Gingival overgrowth in renal transplant recipients: a study concerning prevalence, severity, periodontal, and predisposing factors. Transplant Proc,2008, 40: 1425-8.
  • Aimetti M, Romano F, Priotto P, Debernardi C. Non-surgical periodontal therapy of cyclosporin A gingival overgrowth in organ transplant patients. Clinical results at 12 months. Minerva Stomatol, 2005, 54: 311-9.
  • Darbar UR, Hopper C, Speight PM, Newman HN. Combined treatment approach to gingival overgrowth due to drug therapy. Periodontol,1996, 23: 941-4. J Clin
  • Kara C. Evaluation of patient perceptions of frenectomy: a comparison of Nd:YAG laser and conventional techniques. Photomed Laser Surg, 2008, 26: 147-52.
  • Pogrel MA, Yen CK, Hansen LS. A comparison of carbon dioxide laser, liquid nitrogen cryosurgery, and scalpel wounds in healing. Oral Surg Oral Med Oral Pathol,1990, 69: 269-73.
  • White JM, Goodis HE, Rose CL. Use of the pulsed Nd:YAG laser for intraoral soft tissue surgery. Lasers Surg Med,1991, 11: 455-61.
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Dentistry
Journal Section Articles
Authors

Gülnihal Doğan

Ebru Sağlam This is me

Mehmet Kara This is me

Turgut Demir This is me

Publication Date February 11, 2015
Published in Issue Year 2014 Volume: 24 Issue: Supplement 8

Cite

APA Doğan, G., Sağlam, E., Kara, M., Demir, T. (2015). SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 24(Supplement 8), 18-22. https://doi.org/10.17567/dfd.67582
AMA Doğan G, Sağlam E, Kara M, Demir T. SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU. Ata Diş Hek Fak Derg. February 2015;24(Supplement 8):18-22. doi:10.17567/dfd.67582
Chicago Doğan, Gülnihal, Ebru Sağlam, Mehmet Kara, and Turgut Demir. “SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 24, no. Supplement 8 (February 2015): 18-22. https://doi.org/10.17567/dfd.67582.
EndNote Doğan G, Sağlam E, Kara M, Demir T (February 1, 2015) SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 24 Supplement 8 18–22.
IEEE G. Doğan, E. Sağlam, M. Kara, and T. Demir, “SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU”, Ata Diş Hek Fak Derg, vol. 24, no. Supplement 8, pp. 18–22, 2015, doi: 10.17567/dfd.67582.
ISNAD Doğan, Gülnihal et al. “SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 24/Supplement 8 (February 2015), 18-22. https://doi.org/10.17567/dfd.67582.
JAMA Doğan G, Sağlam E, Kara M, Demir T. SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU. Ata Diş Hek Fak Derg. 2015;24:18–22.
MLA Doğan, Gülnihal et al. “SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, vol. 24, no. Supplement 8, 2015, pp. 18-22, doi:10.17567/dfd.67582.
Vancouver Doğan G, Sağlam E, Kara M, Demir T. SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU. Ata Diş Hek Fak Derg. 2015;24(Supplement 8):18-22.

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