THE EFFECT OF BISPHOSPHONATES AND LOW-DOSE DOXCYCLINE THERAPY IN DIABETICS WITH PERIODONTITIS: A REVIEW

Year 2016, Supplement 16, 65 - 79, 24.11.2016

Şeyma Bozkurt Doğan Figen Özgöz Dede

https://doi.org/10.17567/ataunidfd.290572

Abstract

ABSTRACT

 

Diabetes mellitus and periodontal
disease are chronic diseases affecting a large number of populations worldwide.
The major component of soft and hard tissue destruction associated with
periodontal disease is the result of activation of the host immuno-inflammatory
response to the oral pathogens. Diabetes mellitus alters bacteria–host
interactions by prolonging the inflammatory response and dysregu- lating
cytokine production, and is among the primary risk factors for periodontal
disease. Alveolar bone loss is one of the main outcomes of periodontitis. One
of the important long-term complications associated with diabetes mellitus is
changed bone metabolism. Recently, the therapeutic strategies for the treatment
of periodontal disease have been directed towards to host modulation therapy.
In this review, we will evaluate the effects of bisphosphonates and low dose
doxcycline drugs as host modulation agents in the treatment of periodontal
disease and in diabetics with periodontal disease.

Keywords: Periodontitis,
diabetes mellitus, bisphosphonate, doxycycline, alveolar bone loss 

DÜŞÜK-DOZ DOKSİSİKLİN
VE BİFOSFONAT TEDAVİSİNİN PERİODONTİTİSLİ DİYABET HASTALARINDAKİ ETKİSİ:
DERLEME

ÖZ

 Diabetes
mellitus ve periodontal hastalıklar, dünya popülasyonunun geniş bir kitlesini
etkileyen kronik hastalıklardır. Periodontal hastalıklar ile ilişkili sert ve
yumuşak doku yıkımı, oral patojenlere karşı konak im- muno-inflamatuvar cevabın
aktivasyonu sonucu mey- dana gelmektedir. Diabetes mellitus, sitokin üretiminin
düzenlenmesini bozarak ve inflamatuvar cevabı uzatarak bakteri-konak
etkileşimini değiştirmektedir ve periodontal hastalıklar için başlıca risk
faktörleri ara- sındadır. Periodontitisin temel klinik özelliklerinden biri
alveoler kemik kaybıdır. Diabetes mellitus ile ilişkili önemli uzun-süreli
komplikasyonlarından biri, kemik metabolizmasındaki değişimdir.  Son zamanlarda pe- riodontal hastalığın
tedavisi için uygulanan terapötik stratejiler konak modülasyon tedavisine doğru
yönel- miştir. Bu derlemede, periodontal hastalıklı diyabet hastalarında ve
periodontal hastalığın tedavisinde konak modülasyon ajanları olarak kullanılan
bifosfo- natlar ve düşük-doz doksisiklin ilaçlarının etkilerini değerlendireceğiz.

Anahtar Kelimeler: Periodontit, diabetes mellitus,
bifosfonat, doksisiklin, alveolar kemik kaybı

Keywords

Periodontitis, diabetes mellitus, bisphosphonate, doxycycline

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