Review
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TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME

Year 2016, Supplement 16, 85 - 98, 24.11.2016
https://doi.org/10.17567/ataunidfd.290578

Abstract

Dişeti
çekilmelerinin tedavisi amacıyla pek çok cerrahi teknik ve materyal
tanımlanmıştır. Tüm bu yöntemlerin geliştirilmesindeki amaç operasyon sonrası
hasta konforunu arttırmak, operasyon süresini kısaltmak, komplikasyon
gelişmesini engellemek ve tam kök kapanmasını sağlamak olarak sıralanabilir.
Son dönemlerde açık kök yüzeylerinin örtülmesinde trombosit konsantreleri tek
başına ya da subepitelyal bağ dokusu grefti, aselüler dermal matriks
allogrefti, kollajen sponge ya da mine matriks proteinleri ile birlikte
kullanılmakta ve klinik çalışmalarla sonuçları değerlendirmektedir. Bu
derlemenin amacı açık kök yüzeylerinin kapatılması için kullanılan trombosit
konsantrelerinin tanıtılması ve konuyla ilgili olarak yapılan çalışmaların
sonuçlarının değerlendirilmesidir.



Anahtar Kelimeler: dişeti çekilmesi,
çekilme tedavisi, trombositler, büyüme (farklılaşma) faktörleri



APPLICATION OF
PLATELET CONCENTRATES FOR THE TREATMENT OF GINGIVAL RECESSION DEFECTS: REVIEW

ABSTRACT

 Many surgical techniques and materials have been
identified for the purpose of gingival recession treatment. The aims of all
these methods can be listed to improve patient comfort after surgery, short the
operation time, prevent complications, and provide full root coverage.
Nowadays, platelet concentrates are used alone or with subepithelial connective
tissue graft, acellular dermal matrix allograft, collagen sponge or enamel
matrix proteins in covering the exposed root surface and evaluated outcomes
with clinical studies. The purpose of this review is to introduce of the use
platelet concentrates and evaluate the results of studies with platelet
concentrates to cover denuded root surfaces.







Keywords: gingival recession, withdrawing treatment, platelets, growth
(differentation) factors

References

  • 1. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101:e45-50.
  • 2. Rozman P, Bolta Z. Use of platelet growth factors in treating wounds and soft-tissue injuries. Acta dermatovenerol Alp Panonica Adriat 2007; 16:156-65.
  • 3. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004; 91:4-15.
  • 4. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009; 27:158-67.
  • 5. Soffer E, Ouhayoun JP, Anagnostou F. Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95:521-8.
  • 6. Cheung WS, Griffin TJ. A comparative study of root coverage with connective tissue and platelet concentrate grafts: 8-month results. J Periodontol 2004; 75:1678-87.
  • 7. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85:638-46.
  • 8. Tozum TF, Demiralp B. Platelet-rich plasma: a promising innovation in dentistry. J Can Dent Assoc 2003; 69:664.
  • 9. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101:299-303.
  • 10. Del Fabbro M, Bortolin M, Taschieri S, Weinstein R. Is platelet concentrate advantageous for the surgical treatment of periodontal diseases?A systematic review and meta-analysis. J Periodontol 2011; 82:1100-11.
  • 21. Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scari G, Sacco L, Batani T, Rezzani R. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech 2011; 74:772-7.
  • 22. Yu B, Wang Z. Effect of concentrated growth factors on beagle periodontal ligament stem cells in vitro. Mol Med Rep 2014; 9: 235-42.
  • 23. Sohn DS, Heo JU, Kwak DH, Kim DE, Kim JM, Moon JW, Lee JH, Park IS. Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone. Implant Dent 2011; 20: 389-95.
  • 24. Sohn D.S, Moon JW, Moon YS, Park JS, Jung HS. The use of concentrated growth factors (CGF) for sinus augmentation. J Oral Implantol 2009; 38:25–38.
  • 25. Kim JM, Sohn DS, Bae MS, Moon JW, Lee JH, and Park IS. Flapless transcrestal sinus augmentation using hydrodynamic piezoelectric internal sinus elevation with autologous concentrated growth factors alone. Implant Dent 2014; 23: 168-74.
  • 26. Internet: Corigliano M, Sacco L, Baldoni E, International Academy of Implanto Prosthesis and Osteoconnections the CGF: A Therapeutic Proposal for Regenerative Medicine. URL: www. panoramadentale.it/pdf/CGF.pdf, Son Erişim Tarihi: 08.11.2016.
  • 27. Kim TH, Kim SH, Sandor GK, Kim YD. Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing. Arch Oral Biol 2014; 59: 550-8.
  • 28. Dohan Ehrenfest DM, Bielecki T, Mishra A, Borzini P, Inchingolo F, Sammartino G, Rasmusson L, Evert PA. In search of a consensus terminology in the field of platelet concentrates for surgical use: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes. Curr Pharm Biotechnol. 2012; 13: 1131-7.
  • 29. Dohan Ehrenfest DM, Bielecki T, Jimbo R, Barbe G, Del Corso M, Inchingolo F, Sammartino G. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol. 2012; 13: 1145-52.
  • 30. Internet: Glossary of Periodontal Terms. 4 Edition, Chicago, Periodontology, A.A.O. (2001).URL:http:// www.perio.org/sites/default/files/files/PDFs/Publications/GlossaryOfPeriodontalTerms2001Edition.pdf, Son Erişim Tarihi: 08.11.2016
  • 41. Chambrone L, Pannuti CM, Tu YK, Chambrone LA. Evidence-based periodontal plastic surgery. II. An individual data meta-analysis for evaluating factors in achieving complete root coverage. J Periodontol 2012; 83: 477-490.
  • 42. Cairo F, Pagliaro U, Nieri M. Treatment of gingival recession with coronally advanced flap procedures: a systematic review. J Clin Periodontol 2008; 35: 136-162.
  • 43. Eren G, Atilla G. Platelet-rich fibrin in the treatment of localized gingival recessions: a split-mouth randomized clinical trial. Clin Oral Investig 2014; 18: 1941-8.
  • 44. Jankovic S.M, Zoran AM, Vojislov LM, Dimitrijevic SB, Kenney BE. The use of platelet-rich plasma in combination with connective tissue grafts following treatment of gingival recessions. Periodontal Pract Today 2007; 4: 63-71.
  • 45. Keceli HG, Sengun D, Berberoglu A, Karabulut E. Use of platelet gel with connective tissue grafts for root coverage: a randomized-controlled trial. J Clin Periodontol 2008; 35: 255-62.
  • 46. Huang L.H, Neiva RE, Soehren S.E, Giannobile WV, Wang H.L.The effect of platelet-rich plasma on the coronally advanced flap root coverage procedure: a pilot human trial. J Periodontol 2005; 76:1768-77.
  • 47. Griffin TJ, Cheung WS. Guided tissue regeneration-based root coverage with a platelet concentrate graft: a 3-year follow-up case series. J Periodontol 2009; 80: 1192-9.
  • 48. Shepherd N, Greenwell H, Hill M, Vidal R, Scheetz JP. Root Coverage Using Acellular Dermal Matrix and Comparing a Coronally Positioned Tunnel With and Without Platelet-Rich Plasma: A Pilot Study in Humans. J Periodontol 2009; 80: 397-404.
  • 49. Kumar GN, Murthy KR. A comparative evaluation of subepithelial connective tissue graft (SCTG) versus platelet concentrate graft (PCG) in the treatment of gingival recession using coronally advanced flap technique: A 12-month study. J Indian Soc Periodontol. 2013;17: 771-6.
  • 50. Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009; 80: 244-52.
  • 61. Lundquist R, Dziegiel MH, Agren MS. Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin. Wound Repair Regen. 2008;16:356-63.
  • 62. He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108: 707-13.
  • 63. Del Corso M, Sammartino G, Dohan Ehrenfest DM. Re:Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009; 80: 1694-1697; author reply 1697-9.
  • 64. Dohan Ehrenfest, DM, de Peppo, GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 2009; 27: 63-9.
  • 65. Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM. The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: a new grafting protocol. Implant Dent 2009; 18: 102-11.
  • 66. Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM. The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part II: implant surgery, prosthodontics, and survival. Implant Dent 2009; 18: 220-229.
  • 67. Sezgin Y, Taner L. Trombositten zengin fibrin ve dental uygulamalarda kullanımı. J Dent Fac Ataturk Uni 2012; 22: 325-33
Year 2016, Supplement 16, 85 - 98, 24.11.2016
https://doi.org/10.17567/ataunidfd.290578

Abstract

References

  • 1. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101:e45-50.
  • 2. Rozman P, Bolta Z. Use of platelet growth factors in treating wounds and soft-tissue injuries. Acta dermatovenerol Alp Panonica Adriat 2007; 16:156-65.
  • 3. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004; 91:4-15.
  • 4. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009; 27:158-67.
  • 5. Soffer E, Ouhayoun JP, Anagnostou F. Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95:521-8.
  • 6. Cheung WS, Griffin TJ. A comparative study of root coverage with connective tissue and platelet concentrate grafts: 8-month results. J Periodontol 2004; 75:1678-87.
  • 7. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85:638-46.
  • 8. Tozum TF, Demiralp B. Platelet-rich plasma: a promising innovation in dentistry. J Can Dent Assoc 2003; 69:664.
  • 9. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101:299-303.
  • 10. Del Fabbro M, Bortolin M, Taschieri S, Weinstein R. Is platelet concentrate advantageous for the surgical treatment of periodontal diseases?A systematic review and meta-analysis. J Periodontol 2011; 82:1100-11.
  • 21. Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scari G, Sacco L, Batani T, Rezzani R. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech 2011; 74:772-7.
  • 22. Yu B, Wang Z. Effect of concentrated growth factors on beagle periodontal ligament stem cells in vitro. Mol Med Rep 2014; 9: 235-42.
  • 23. Sohn DS, Heo JU, Kwak DH, Kim DE, Kim JM, Moon JW, Lee JH, Park IS. Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone. Implant Dent 2011; 20: 389-95.
  • 24. Sohn D.S, Moon JW, Moon YS, Park JS, Jung HS. The use of concentrated growth factors (CGF) for sinus augmentation. J Oral Implantol 2009; 38:25–38.
  • 25. Kim JM, Sohn DS, Bae MS, Moon JW, Lee JH, and Park IS. Flapless transcrestal sinus augmentation using hydrodynamic piezoelectric internal sinus elevation with autologous concentrated growth factors alone. Implant Dent 2014; 23: 168-74.
  • 26. Internet: Corigliano M, Sacco L, Baldoni E, International Academy of Implanto Prosthesis and Osteoconnections the CGF: A Therapeutic Proposal for Regenerative Medicine. URL: www. panoramadentale.it/pdf/CGF.pdf, Son Erişim Tarihi: 08.11.2016.
  • 27. Kim TH, Kim SH, Sandor GK, Kim YD. Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing. Arch Oral Biol 2014; 59: 550-8.
  • 28. Dohan Ehrenfest DM, Bielecki T, Mishra A, Borzini P, Inchingolo F, Sammartino G, Rasmusson L, Evert PA. In search of a consensus terminology in the field of platelet concentrates for surgical use: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes. Curr Pharm Biotechnol. 2012; 13: 1131-7.
  • 29. Dohan Ehrenfest DM, Bielecki T, Jimbo R, Barbe G, Del Corso M, Inchingolo F, Sammartino G. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol. 2012; 13: 1145-52.
  • 30. Internet: Glossary of Periodontal Terms. 4 Edition, Chicago, Periodontology, A.A.O. (2001).URL:http:// www.perio.org/sites/default/files/files/PDFs/Publications/GlossaryOfPeriodontalTerms2001Edition.pdf, Son Erişim Tarihi: 08.11.2016
  • 41. Chambrone L, Pannuti CM, Tu YK, Chambrone LA. Evidence-based periodontal plastic surgery. II. An individual data meta-analysis for evaluating factors in achieving complete root coverage. J Periodontol 2012; 83: 477-490.
  • 42. Cairo F, Pagliaro U, Nieri M. Treatment of gingival recession with coronally advanced flap procedures: a systematic review. J Clin Periodontol 2008; 35: 136-162.
  • 43. Eren G, Atilla G. Platelet-rich fibrin in the treatment of localized gingival recessions: a split-mouth randomized clinical trial. Clin Oral Investig 2014; 18: 1941-8.
  • 44. Jankovic S.M, Zoran AM, Vojislov LM, Dimitrijevic SB, Kenney BE. The use of platelet-rich plasma in combination with connective tissue grafts following treatment of gingival recessions. Periodontal Pract Today 2007; 4: 63-71.
  • 45. Keceli HG, Sengun D, Berberoglu A, Karabulut E. Use of platelet gel with connective tissue grafts for root coverage: a randomized-controlled trial. J Clin Periodontol 2008; 35: 255-62.
  • 46. Huang L.H, Neiva RE, Soehren S.E, Giannobile WV, Wang H.L.The effect of platelet-rich plasma on the coronally advanced flap root coverage procedure: a pilot human trial. J Periodontol 2005; 76:1768-77.
  • 47. Griffin TJ, Cheung WS. Guided tissue regeneration-based root coverage with a platelet concentrate graft: a 3-year follow-up case series. J Periodontol 2009; 80: 1192-9.
  • 48. Shepherd N, Greenwell H, Hill M, Vidal R, Scheetz JP. Root Coverage Using Acellular Dermal Matrix and Comparing a Coronally Positioned Tunnel With and Without Platelet-Rich Plasma: A Pilot Study in Humans. J Periodontol 2009; 80: 397-404.
  • 49. Kumar GN, Murthy KR. A comparative evaluation of subepithelial connective tissue graft (SCTG) versus platelet concentrate graft (PCG) in the treatment of gingival recession using coronally advanced flap technique: A 12-month study. J Indian Soc Periodontol. 2013;17: 771-6.
  • 50. Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009; 80: 244-52.
  • 61. Lundquist R, Dziegiel MH, Agren MS. Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin. Wound Repair Regen. 2008;16:356-63.
  • 62. He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108: 707-13.
  • 63. Del Corso M, Sammartino G, Dohan Ehrenfest DM. Re:Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009; 80: 1694-1697; author reply 1697-9.
  • 64. Dohan Ehrenfest, DM, de Peppo, GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 2009; 27: 63-9.
  • 65. Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM. The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: a new grafting protocol. Implant Dent 2009; 18: 102-11.
  • 66. Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM. The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part II: implant surgery, prosthodontics, and survival. Implant Dent 2009; 18: 220-229.
  • 67. Sezgin Y, Taner L. Trombositten zengin fibrin ve dental uygulamalarda kullanımı. J Dent Fac Ataturk Uni 2012; 22: 325-33
There are 37 citations in total.

Details

Journal Section Articles
Authors

Serap Karakış This is me

Berrin Ünsal This is me

Publication Date November 24, 2016
Published in Issue Year 2016 Supplement 16

Cite

APA Karakış, S., & Ünsal, B. (2016). TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi85-98. https://doi.org/10.17567/ataunidfd.290578
AMA Karakış S, Ünsal B. TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME. Ata Diş Hek Fak Derg. Published online November 1, 2016:85-98. doi:10.17567/ataunidfd.290578
Chicago Karakış, Serap, and Berrin Ünsal. “TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, November (November 2016), 85-98. https://doi.org/10.17567/ataunidfd.290578.
EndNote Karakış S, Ünsal B (November 1, 2016) TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 85–98.
IEEE S. Karakış and B. Ünsal, “TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME”, Ata Diş Hek Fak Derg, pp. 85–98, November 2016, doi: 10.17567/ataunidfd.290578.
ISNAD Karakış, Serap - Ünsal, Berrin. “TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. November 2016. 85-98. https://doi.org/10.17567/ataunidfd.290578.
JAMA Karakış S, Ünsal B. TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME. Ata Diş Hek Fak Derg. 2016;:85–98.
MLA Karakış, Serap and Berrin Ünsal. “TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 2016, pp. 85-98, doi:10.17567/ataunidfd.290578.
Vancouver Karakış S, Ünsal B. TROMBOSİT KONSANTRELERİNİN DİŞETİ ÇEKİLMELERİNİN TEDAVİSİ AMACIYLA KULLANIMLARI: DERLEME. Ata Diş Hek Fak Derg. 2016:85-98.

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