REJENERATİF ENDODONTİDE BÜYÜME FAKTÖRLERİ

Year 2018, Volume: 28 Issue: 1, 113 - 124, 28.03.2018

Halise Filiz Kabakcı Ali Erdemir

https://doi.org/10.17567/ataunidfd.410506

Abstract

Rejeneratif
tedaviler progenitör/kök hücreler, doku iskeleleri ve büyüme faktörleri olmak
üzere üç bileşene dayalıdır. Büyüme faktörleri sinyal molekülleri olarak
davranan polipeptidlerdir ve farklılaşma, çoğalma ve migrasyonu içeren hücresel
olayları modüle ederler. Hücresel aktivitelerin düzenlenmesi sırasında, büyüme
faktörleri kendilerine özgü hücre yüzey reseptörlerine bağlanırlar ve hücre içi
sinyal yolakları ve transkripsiyon faktörlerini kullanırlar. Transforme edici
büyüme faktörü, vasküler endotelyal büyüme faktörü, platelet kaynaklı büyüme
faktörü, fibroblast büyüme faktörü ve insülin benzeri büyüme faktörü
pulpa-dentin kompleksinin tamir ve rejenerasyonunda etkilerinin gösterildiği
rejeneratif endodontik çalışmalara konu olan büyüme faktörleridir. Bu
derlemenin amacı, hücre içi fonksiyonlarda büyüme faktörlerinin önemini
tartışmaktır.

Anahtar Kelimeler: Büyüme faktörleri, rejeneratif endodonti, pulpa-dentin kompleksi

GROWTH FACTORS IN
REGENERATIVE ENDODONTICS

ABSTRACT

Regenerative
therapies are based on three components which are progenitor/stem cells,
scaffolds and growth factors. Growth factors are polypeptides that act as
signal molecules and modulate celullar actions including differentiation,
proliferation and migration. During the regulation of cellular activities, they
bind specific cell-surface receptors and use intracellular signalling pathways
and transcription factors. Transforming Growth Factor, Vascular Endothelial
Growth Factor, Platelet Derived Growth Factor, Fibroblast Growth Factor and
Insulin-like Growth Factor are growth factors mostly subjected to regenerative
endodontic studies in which their effects are displayed on pulp-dentine complex
repair and regeneration. The aim of this review is to discuss the importance of
growth factors in intracellular functions.

Keywords: Growth factors, regenerative
endodontics, pulp-dentine complex

Keywords

Büyüme faktörleri, rejeneratif endodonti

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