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BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ

Year 2019, Volume: 29 Issue: 1, 89 - 97, 15.01.2019
https://doi.org/10.17567/ataunidfd.522770

Abstract



Amaç: Bu çalışman amacı bifosfonata bağlı çene
kemiğinin osteonekrozu (Bisphosphonate Related Osteonecrosis of the Jaws
[BRONJ]) tanısı konmuş
hastaların, yapılan
medikal ve cerrahi tedavileri sonra- sında tedavilerinin başarısını görmek ve
uzun dönem takibin önemini vurgulamaktır.

Gereç
ve Yöntem:
BRONJ tanısı konulmuş, altısı kadın ikisi erkek olmak üzere 8
hastanın ilaç ve cerrahi tedavileri ve uzun dönem klinik ve radyolojik takip
sonuçları değerlendirilmiştir.  Ruggiero
ve arkadaşları- nın oluşturduğu evrelendirmeye göre vakalar evrelen- dirilmiş
ve tedavileri yapılmıştır. Hastaların üçü osteo- poroz (biri intravenöz, ikisi
oral yoldan), kalan beşi malignite (intravenöz yoldan) nedeneniyle bifosfonat
kullanmaktadır.

Bulgular: Hastalar 8
ila 43 ay arasında değişen, ortalama 23.8 aylık süreyle bifosfonat grubu ilaç
almışlardır. Hastaların ortalama yaşları 61.2 ve tedavi sonrası ortalama takip
süreleri ise 12.5 aydır. , 8 vakanın beşi evre 3, diğer üçü ise evre 2 olarak
değer- lendirilmiştir. Evre 3 hastaların hiçbirinde, medikal ve cerrahi tedavi
sonrası belirtilen takip süresince klinik ve radyolojik olarak BRONJ rekürrensi
görülmemiştir. Evre 2 vakalarda ise ilaç tedavisi sonrası hastalık semptomatik
olarak kontrol altına alınmıştır.

Sonuç :
Sonuç olarak uygulanan bu tedavi protokolü ve bu çalışmaya dahil edilen
vakalardan elde edilen veriler, cerrahi tedavinin gerektiğinde uygun zamanda yapılmasının
önemini güçlendirmiştir. Ayrıca hiperbarik oksijen tedavisinin BRONJ
vakalarında yardımcı tedavi yöntemlerinden biri olarak düşünülebileceği söylene-
bilir. Bifosfonat kullanım nedenleri hastaların cerrahi ya da medikal yolla
tedavi edilmelerinde direkt olarak etkili olmamıştır.

Anahtar kelimeler: Bifosfonat, çene osteonekrozu, hiperbarik
oksijen tedavisi

LONG TERM FOLLOW UP OF PATIENTS WITH BISPHOSPHONATE
RELATED OSTEONECROSIS OF THE JAWS AFTER MEDICAL AND SURGICAL TREATMENT

ABSTRACT

Aim: The aim of this study is to observe the success
of medical and surgical treatment of the patients who have been diagnosed as
the bisphosphonate related osteonecrosis of the jaws (BRONJ) and emphasize the
importance of long term follow up of these patients. Material and Methods: The medical and surgical treatments and long
term clinical and radiological follow ups of 8 BRONJ cases, of whom 6 women and
2 men, were evaluated in this study. All cases were staged according to a
staging system that was imple- mented by Ruggiero et al. and treated
accordingly. Three of the patients (one intravenously and two orally) were on
bisphosphonate due to osteoporosis and five of them (intravenously) due to
malignant diseases. Results: Patients
were on bisphosphonate for an interval of 8 to 43 months with a mean time
period of 23.8 months. The mean age of the patients was 61.2 and the mean
postoperative follow up time was 12.5 months. According to Ruggiero et al BRONJ
staging, 5 of 8 cases were at stage-3 and the rest of them were at stage-2.
None of the stage-3 cases that were treated medically and surgically showed any
BRONJ recurrence clinically and radiographically during their follow up
periods. Also, all three stage-2 BRONJ cases were kept under control
symptomatically with medical treatment protocol. 




Conclusion: As a conclusion, the treatment
protocol and outcome data of this study on BRONJ cases have reinforced the
importance of surgical treatment that is performed at an
appropriate time.  Also it is possible to emphasize that
hyperbaric oxygen treatment can be an adjuvant treatment method for BRONJ
cases. The reason of bisphosphonate usage of these patients did not directly
have any effect on either they treated surgically or medically.
Key Words: Bisphosphonate, jaw osteonecrosis, hyperbaric oxygen treatment






References

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  • 2-Wood J, Bonjean K, Ruetz S, Ballahcene A, Devy L, Foidart JM. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 2002;302:1055-61.
  • 3- Santini D, Vincenzi B, Avvisati G, Dicuonzo G, Salerno A, Denaro V. Pamidronate ınduces modifications of circulating angiogenic factors in cancer patients. Clin Cancer Res 2002; 8:1080-4.
  • 4-Calvani F, Cutone A, Lepanto MS, Rosa L, Valantini V, Valenti P. Efficacy of bovine lactoferrin in the post-surgical treatment of patients suffering from bisphosphonate-related osteonecrosis of the jaws: an open-label study. Biometals 2018;doi: 10.1007/s10534-018-0081-y. Basım aşamasında.
  • 5-Bone HG, Hosking D, Devogelsaer J-P, Tucci JR, Emky RD, Tonino RP. Ten years’ experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med 2004;350:1189-99.
  • 6-Reid IR, Miller P, Lyles K, Fraser W, Brown JP, Saidi Y. Comparison of a single ınfusion of zoledronic acid with risedronate for paget’s disease. N Engl J Med 2005;353:898-908.
  • 7. Deftos LJ. treatment of paget’s disease—taming the wild osteoclasts. N Engl J Med 2005;353:872-5.
  • 8. Çapar GD, Cabbar F, Yalçın M, Tomruk CÖ. İlaçlara bağlı çene osteonekrozu: derleme. Atatürk Üniv Diş Hek Fak Derg 2015;13:118-29.
  • 9- Coello-Suanzes JA, Rollon-Ugalde V, Castano-Seiquer A, Lledo-Villar E, Herce-Lopez J, Infante-Cossio P, Rollon-Mayordomo A. preventive dental management of osteonecrosis of the jaws related to zoledronic acid treatment. Oral Dis. 2018;doi: 10.1111/odi.12842. Basım aşamasında.
  • 10- Marx RE: Pamidronate (Aredia)- and zoledronate (zometa)-induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003;61:1115-7.
  • 11- Ruggiero SL, Fantasia J, Carlson E. bisphosphonate- related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:433-40.
  • 12-Mehrotra B, Fantasia J, Nissel-Horowitz S, Vinarsky S, Ruggiero S. osteonecrosis of the maxilla: an unusual complication of prolonged bisphosphonate therapy. a case report. Proc Am Soc Clin Oncol 2003;22:795.
  • 13-Migliorati CA. bisphosphonates and oral cavity avascular bone necrosis. J Clin Oncol 2003;21:4253-4.
  • 14-Yasuda H, Shima N, Nakagawa N. osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is ıdentical to TRANCE/RANKL. Proc Natl Acad Sci 1998;95:3597–602.
  • 15- Lacey DL, Timms E, Tan HL. Osteoprotegerin Ligand is a Cytokine that regulates osteoclast differentiation and activation. Cell 1998;93:165–76.
  • 16- Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T, Higashio K. Isolation of a novel cytokine from human fibroblasts that specifically ınhibits osteoclastogenesis. Biochem Biophys Res Commun 1997;234:137–42.
  • 17- Simonet WS, Lacey DL, Dunstan CR. Osteoprotegerin: A novel secreted protein ınvolved in the regulation of bone density. Cell 1997;89:309–9.
  • 18- Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999;20:345–357.
  • 19- Jimi E, Furuta H, Matsuo K, Tominaga K, Takahashi T, Nakanishi O. The cellular and molecular mechanisms of bone ınvasion by oral squamous cell carcinoma. Oral Diseases 2011;17:462-8.
  • 20- Shin M, Matsuo K, Tada T, Fukushima H, Furuta H, Ozeki S, Kadowaki T, Yamamoto K, Okamoto M, Jimi E. The Inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone ınvasion by oral squamous cell carcinoma cells. Carcinogenesis 2011;32: 1634-40.
  • 21- Martin CK, Dirksen WP, Carlton MM, Lanigan LG, Pillai SP, Werbeck JL, Simmons JK, Hildreth III BE, London CA, Toribio RE, Rosol TJ. Combined zoledronic acid and metoxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-ınvasive oral squamous cell carcinoma. Veterinary and Comparative Oncology 2015;13:203-17.
  • 22- Patel V, Mansi J, Ghosh S, Kwok J, Burke M, Reilly D, Nizarali N, Sproat C, Chia K. MRONJ Risk of adjuvant bisphosphonates in early stage breast cancer. . Br Dent J 2018;224:74-79.
  • 23- Müller H, Slootweg PJ. Mandibular ınvasion by oral squamous cell carcinoma. clinical aspects. J Craniomaxillofac Surg 1990;18:80–4.
  • 24- Totsuka Y, Usui Y, Tei K, Kida M, Mizukoshi T, Notani K, Fukuda H. Results of surgical treatment for squamous carcinoma of the lower alveolus: segmental vs. marginal resection. Head Neck 1991;13:114-20.
  • 25- Wong RJ, Keel SB, Glynn RJ, Varvares MA. Histological pattern of mandibular ınvasion by oral squamous cell carcinoma. Laryngoscope 2000;110:65–72.
  • 26- Guise TA, Mundy GR. Cancer and bone. Endocr Rev 1998;19:18–54.
  • 27- Takayama Y, Mori T, Nomura T, Shibahara T, Sakamoto M. Parathroid-related protein plays a critical role in bone ınvasion by oral squamous cell carcinoma. Int J Onco 2010;36:1387-94.
  • 28-- Ha H, Kwak HB, Lee SW. Reactive oxygen species mediate rank signaling in osteoclasts. Exp Cell Res 2004;301:119-27.
  • 29. Lee NK, Choi YG, Baik JY. A Crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 2005;106:852-9.
  • 30. Reddy SV. Regulatory mechanisms operative in osteoclasts. Crit Rev Eukaryot Gene Expr 2004;14:255-70.
  • 31- Berenson JR, Hillner BE, Kyle RA, Anderson K, Lipton A, Yee GC, Biermann JS. American society of clinical oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma. J Clin Oncol 2002;20:3719-36.
  • 32- Dimopoulos M, Kastritis E, Moulopoulos LA, Melakopoulos I, Anagnostopoulos A, Gika D. The Incidence of Osteonecrosis of the Jaw in Patients with Multiple Myeloma who Receive Bisphosphonates Depends on the Type of Bisphosphonate. Blood 2005;106:Abstract #637
  • 33- Migliorati CA, Casiglia J, Epstein J, Siegel, MA, Woo SB. Managing the Care of Patients with Bisphosphonate-Associated Osteonecrosis. JADA 2005;136:1658-68.
  • 34- Durie BGM, Katz M, Crowley J. Osteonecrosis of the Jaw and Bisphosphonates. N Engl J Med 2005;353:99.
  • 35- Dal Pra´ KJ, Lemos CAA, Okamoto R, Soubhia AMP, Pellizzer E. Efficacy of the C-terminal Telopeptide Test in Predicting the Development of Bisphosphonate-related Osteonecrosis of the Jaw: A Systematic Review. Int J Oral Maxillofac Surg 2017;46:151–6.
  • 36- Beninati F, Pruneti R, Ficarra G. Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ). Med Oral Patol Oral Cir Bucal 2013;18:e752–8.
  • 37- Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff S. Osteonecrosis of the Jaws Associated with the Use of Bisphosphonates: A Review of 63 Cases. J Oral Maxillofac Surg 2004;62:527-34.
  • 38- Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonate Induced Exposed Bone (osteonecrosis/osteopetrosis) of the Jaws: Risk Factors, Recognition, Prevention and Treatment. J Oral Maxillofac Surg 2005;63:1567-75.
  • 39- Lee CY, Suzuki JB. CTX Biochemical Marker of Bone Metabolism. Is It a Reliable Predictor of Bisphosphonate-associated Osteonecrosis of the Jaws After Surgery? Part I: Biological Concepts with a Review of the Literature. Implant Dent 2009;18:492–500.
  • 40- Marx RE, Cillo JE, Ulloa JJ. Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum ctx testing, prevention, and treatment. J Oral Maxillofac Surg 2007;65:2397–410.
  • 41-Kwon YD, Kim DY, Ohe JY, Yoo JY, Walter C. correlation between serum c-terminal cross-linking telopeptide of type ı collagen and staging of oral bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 2009;67:2644–8.
  • 42. Kwon YD, Ohe JY, Kim DY, Chung DJ, Park YD. Retrospective study of two biochemical markers for the risk assessment of oral bisphosphonate-related osteonecrosis of the jaws: can they be utilized as risk markers? Clin Oral Implants Res 2011;22:100–5.
  • 43-Flichy-Fernandez AJ, Gonzalez-Lemonnier S, Balaguer-Martinez J, Penarrocha-Oltra D, Penarrocha-Diago MA, Bagan-Sebastian JV. bone necrosis around dental ımplants: a patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX. J Clin Exp Dent 2012;4:e82–5.
  • 44. Friedlander AH, Chang TI, Hazboun RC, Garrett NR. High c-terminal cross-linking telopeptide levels are associated with a minimal risk of osteonecrosis of the jaws ın patients taking oral bisphosphonates and having exodontia. J Oral Maxillofac Surg 2015;73:1735–40.
  • 45- Hutcheson A, Cheng A, Kunchar R, Stein B, Sambrook P, Goss A. A c-terminal cross-linking telopeptide test based protocol for patients on oral bisphosphonates requiring extraction: a prospective single center controlled study. J Oral Maxillofac Surg 2014;72:1456–62.
  • 46. Migliorati CA, Saunders D, Conlon MS, Ingstad HK, Vaagen P, Palazzolo MJ. Assessing the association between bisphosphonate exposure and delayed mucosal healing after tooth extraction. J Am Dent Assoc 2013;144:406–14.
  • 47-Landesberg R, Wilson T, Grbic JT. Bisphosphonate-associated Osteonecrosis of the Jaw: conclusions based on an analysis of case series. Dent Today 2006;25:52,54-7.
  • 48-Mignogna MD, Fedele S, Lo Russo L. Case 2: osteonecrosis of the jaws associated with bisphosphonate therapy. J Clin Oncol 2006;24:1475-77.
  • 49- Soileau KM. Oral post-surgical complications following the administration of bisphosphonates given for osteopenia related to malignancy. J Periodontol 2006;77:738-43.
  • 50- Freiberger JJ, Padilla-Burgos R, Chhoeu AH, Kraft KH, Boneta O, Moon RE, Piantadosi CA. Hyperbaric oxygen treatment and bisphosphonate-ınduced osteonecrosis of the jaw: a case series. J Oral Maxillofac Surg 2007;65:1321-27.
  • 51- Bermúdez-Bejarano EB, Serrera-Figallo MA, Gutiérrez-Corrales A, Romero-Ruiz MM, Castillo-de-Oyagüe R, Gutiérrez-Pérez JL, Torres-Lagares D. Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and ıntravenous bisphosphonates. J Clin Exp Dent 2017;9:e141-9.
Year 2019, Volume: 29 Issue: 1, 89 - 97, 15.01.2019
https://doi.org/10.17567/ataunidfd.522770

Abstract

References

  • 1-Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B. American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw—2014 update. J Oral Maxillofac Surg 2014;72:1938–56.
  • 2-Wood J, Bonjean K, Ruetz S, Ballahcene A, Devy L, Foidart JM. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 2002;302:1055-61.
  • 3- Santini D, Vincenzi B, Avvisati G, Dicuonzo G, Salerno A, Denaro V. Pamidronate ınduces modifications of circulating angiogenic factors in cancer patients. Clin Cancer Res 2002; 8:1080-4.
  • 4-Calvani F, Cutone A, Lepanto MS, Rosa L, Valantini V, Valenti P. Efficacy of bovine lactoferrin in the post-surgical treatment of patients suffering from bisphosphonate-related osteonecrosis of the jaws: an open-label study. Biometals 2018;doi: 10.1007/s10534-018-0081-y. Basım aşamasında.
  • 5-Bone HG, Hosking D, Devogelsaer J-P, Tucci JR, Emky RD, Tonino RP. Ten years’ experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med 2004;350:1189-99.
  • 6-Reid IR, Miller P, Lyles K, Fraser W, Brown JP, Saidi Y. Comparison of a single ınfusion of zoledronic acid with risedronate for paget’s disease. N Engl J Med 2005;353:898-908.
  • 7. Deftos LJ. treatment of paget’s disease—taming the wild osteoclasts. N Engl J Med 2005;353:872-5.
  • 8. Çapar GD, Cabbar F, Yalçın M, Tomruk CÖ. İlaçlara bağlı çene osteonekrozu: derleme. Atatürk Üniv Diş Hek Fak Derg 2015;13:118-29.
  • 9- Coello-Suanzes JA, Rollon-Ugalde V, Castano-Seiquer A, Lledo-Villar E, Herce-Lopez J, Infante-Cossio P, Rollon-Mayordomo A. preventive dental management of osteonecrosis of the jaws related to zoledronic acid treatment. Oral Dis. 2018;doi: 10.1111/odi.12842. Basım aşamasında.
  • 10- Marx RE: Pamidronate (Aredia)- and zoledronate (zometa)-induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003;61:1115-7.
  • 11- Ruggiero SL, Fantasia J, Carlson E. bisphosphonate- related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:433-40.
  • 12-Mehrotra B, Fantasia J, Nissel-Horowitz S, Vinarsky S, Ruggiero S. osteonecrosis of the maxilla: an unusual complication of prolonged bisphosphonate therapy. a case report. Proc Am Soc Clin Oncol 2003;22:795.
  • 13-Migliorati CA. bisphosphonates and oral cavity avascular bone necrosis. J Clin Oncol 2003;21:4253-4.
  • 14-Yasuda H, Shima N, Nakagawa N. osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is ıdentical to TRANCE/RANKL. Proc Natl Acad Sci 1998;95:3597–602.
  • 15- Lacey DL, Timms E, Tan HL. Osteoprotegerin Ligand is a Cytokine that regulates osteoclast differentiation and activation. Cell 1998;93:165–76.
  • 16- Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T, Higashio K. Isolation of a novel cytokine from human fibroblasts that specifically ınhibits osteoclastogenesis. Biochem Biophys Res Commun 1997;234:137–42.
  • 17- Simonet WS, Lacey DL, Dunstan CR. Osteoprotegerin: A novel secreted protein ınvolved in the regulation of bone density. Cell 1997;89:309–9.
  • 18- Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999;20:345–357.
  • 19- Jimi E, Furuta H, Matsuo K, Tominaga K, Takahashi T, Nakanishi O. The cellular and molecular mechanisms of bone ınvasion by oral squamous cell carcinoma. Oral Diseases 2011;17:462-8.
  • 20- Shin M, Matsuo K, Tada T, Fukushima H, Furuta H, Ozeki S, Kadowaki T, Yamamoto K, Okamoto M, Jimi E. The Inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone ınvasion by oral squamous cell carcinoma cells. Carcinogenesis 2011;32: 1634-40.
  • 21- Martin CK, Dirksen WP, Carlton MM, Lanigan LG, Pillai SP, Werbeck JL, Simmons JK, Hildreth III BE, London CA, Toribio RE, Rosol TJ. Combined zoledronic acid and metoxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-ınvasive oral squamous cell carcinoma. Veterinary and Comparative Oncology 2015;13:203-17.
  • 22- Patel V, Mansi J, Ghosh S, Kwok J, Burke M, Reilly D, Nizarali N, Sproat C, Chia K. MRONJ Risk of adjuvant bisphosphonates in early stage breast cancer. . Br Dent J 2018;224:74-79.
  • 23- Müller H, Slootweg PJ. Mandibular ınvasion by oral squamous cell carcinoma. clinical aspects. J Craniomaxillofac Surg 1990;18:80–4.
  • 24- Totsuka Y, Usui Y, Tei K, Kida M, Mizukoshi T, Notani K, Fukuda H. Results of surgical treatment for squamous carcinoma of the lower alveolus: segmental vs. marginal resection. Head Neck 1991;13:114-20.
  • 25- Wong RJ, Keel SB, Glynn RJ, Varvares MA. Histological pattern of mandibular ınvasion by oral squamous cell carcinoma. Laryngoscope 2000;110:65–72.
  • 26- Guise TA, Mundy GR. Cancer and bone. Endocr Rev 1998;19:18–54.
  • 27- Takayama Y, Mori T, Nomura T, Shibahara T, Sakamoto M. Parathroid-related protein plays a critical role in bone ınvasion by oral squamous cell carcinoma. Int J Onco 2010;36:1387-94.
  • 28-- Ha H, Kwak HB, Lee SW. Reactive oxygen species mediate rank signaling in osteoclasts. Exp Cell Res 2004;301:119-27.
  • 29. Lee NK, Choi YG, Baik JY. A Crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 2005;106:852-9.
  • 30. Reddy SV. Regulatory mechanisms operative in osteoclasts. Crit Rev Eukaryot Gene Expr 2004;14:255-70.
  • 31- Berenson JR, Hillner BE, Kyle RA, Anderson K, Lipton A, Yee GC, Biermann JS. American society of clinical oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma. J Clin Oncol 2002;20:3719-36.
  • 32- Dimopoulos M, Kastritis E, Moulopoulos LA, Melakopoulos I, Anagnostopoulos A, Gika D. The Incidence of Osteonecrosis of the Jaw in Patients with Multiple Myeloma who Receive Bisphosphonates Depends on the Type of Bisphosphonate. Blood 2005;106:Abstract #637
  • 33- Migliorati CA, Casiglia J, Epstein J, Siegel, MA, Woo SB. Managing the Care of Patients with Bisphosphonate-Associated Osteonecrosis. JADA 2005;136:1658-68.
  • 34- Durie BGM, Katz M, Crowley J. Osteonecrosis of the Jaw and Bisphosphonates. N Engl J Med 2005;353:99.
  • 35- Dal Pra´ KJ, Lemos CAA, Okamoto R, Soubhia AMP, Pellizzer E. Efficacy of the C-terminal Telopeptide Test in Predicting the Development of Bisphosphonate-related Osteonecrosis of the Jaw: A Systematic Review. Int J Oral Maxillofac Surg 2017;46:151–6.
  • 36- Beninati F, Pruneti R, Ficarra G. Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ). Med Oral Patol Oral Cir Bucal 2013;18:e752–8.
  • 37- Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff S. Osteonecrosis of the Jaws Associated with the Use of Bisphosphonates: A Review of 63 Cases. J Oral Maxillofac Surg 2004;62:527-34.
  • 38- Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonate Induced Exposed Bone (osteonecrosis/osteopetrosis) of the Jaws: Risk Factors, Recognition, Prevention and Treatment. J Oral Maxillofac Surg 2005;63:1567-75.
  • 39- Lee CY, Suzuki JB. CTX Biochemical Marker of Bone Metabolism. Is It a Reliable Predictor of Bisphosphonate-associated Osteonecrosis of the Jaws After Surgery? Part I: Biological Concepts with a Review of the Literature. Implant Dent 2009;18:492–500.
  • 40- Marx RE, Cillo JE, Ulloa JJ. Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum ctx testing, prevention, and treatment. J Oral Maxillofac Surg 2007;65:2397–410.
  • 41-Kwon YD, Kim DY, Ohe JY, Yoo JY, Walter C. correlation between serum c-terminal cross-linking telopeptide of type ı collagen and staging of oral bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 2009;67:2644–8.
  • 42. Kwon YD, Ohe JY, Kim DY, Chung DJ, Park YD. Retrospective study of two biochemical markers for the risk assessment of oral bisphosphonate-related osteonecrosis of the jaws: can they be utilized as risk markers? Clin Oral Implants Res 2011;22:100–5.
  • 43-Flichy-Fernandez AJ, Gonzalez-Lemonnier S, Balaguer-Martinez J, Penarrocha-Oltra D, Penarrocha-Diago MA, Bagan-Sebastian JV. bone necrosis around dental ımplants: a patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX. J Clin Exp Dent 2012;4:e82–5.
  • 44. Friedlander AH, Chang TI, Hazboun RC, Garrett NR. High c-terminal cross-linking telopeptide levels are associated with a minimal risk of osteonecrosis of the jaws ın patients taking oral bisphosphonates and having exodontia. J Oral Maxillofac Surg 2015;73:1735–40.
  • 45- Hutcheson A, Cheng A, Kunchar R, Stein B, Sambrook P, Goss A. A c-terminal cross-linking telopeptide test based protocol for patients on oral bisphosphonates requiring extraction: a prospective single center controlled study. J Oral Maxillofac Surg 2014;72:1456–62.
  • 46. Migliorati CA, Saunders D, Conlon MS, Ingstad HK, Vaagen P, Palazzolo MJ. Assessing the association between bisphosphonate exposure and delayed mucosal healing after tooth extraction. J Am Dent Assoc 2013;144:406–14.
  • 47-Landesberg R, Wilson T, Grbic JT. Bisphosphonate-associated Osteonecrosis of the Jaw: conclusions based on an analysis of case series. Dent Today 2006;25:52,54-7.
  • 48-Mignogna MD, Fedele S, Lo Russo L. Case 2: osteonecrosis of the jaws associated with bisphosphonate therapy. J Clin Oncol 2006;24:1475-77.
  • 49- Soileau KM. Oral post-surgical complications following the administration of bisphosphonates given for osteopenia related to malignancy. J Periodontol 2006;77:738-43.
  • 50- Freiberger JJ, Padilla-Burgos R, Chhoeu AH, Kraft KH, Boneta O, Moon RE, Piantadosi CA. Hyperbaric oxygen treatment and bisphosphonate-ınduced osteonecrosis of the jaw: a case series. J Oral Maxillofac Surg 2007;65:1321-27.
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There are 51 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Araştırma Makalesi
Authors

Necip Fazıl Erdem 0000-0002-5374-3233

Zeynep Gümüşer This is me 0000-0002-7834-4343

Publication Date January 15, 2019
Published in Issue Year 2019 Volume: 29 Issue: 1

Cite

APA Erdem, N. F., & Gümüşer, Z. (2019). BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 29(1), 89-97. https://doi.org/10.17567/ataunidfd.522770
AMA Erdem NF, Gümüşer Z. BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ. Ata Diş Hek Fak Derg. January 2019;29(1):89-97. doi:10.17567/ataunidfd.522770
Chicago Erdem, Necip Fazıl, and Zeynep Gümüşer. “BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29, no. 1 (January 2019): 89-97. https://doi.org/10.17567/ataunidfd.522770.
EndNote Erdem NF, Gümüşer Z (January 1, 2019) BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29 1 89–97.
IEEE N. F. Erdem and Z. Gümüşer, “BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ”, Ata Diş Hek Fak Derg, vol. 29, no. 1, pp. 89–97, 2019, doi: 10.17567/ataunidfd.522770.
ISNAD Erdem, Necip Fazıl - Gümüşer, Zeynep. “BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29/1 (January 2019), 89-97. https://doi.org/10.17567/ataunidfd.522770.
JAMA Erdem NF, Gümüşer Z. BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ. Ata Diş Hek Fak Derg. 2019;29:89–97.
MLA Erdem, Necip Fazıl and Zeynep Gümüşer. “BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, vol. 29, no. 1, 2019, pp. 89-97, doi:10.17567/ataunidfd.522770.
Vancouver Erdem NF, Gümüşer Z. BİFOSFONAT KULLANIMINA BAĞLI ÇENE KEMİKLERİNDE GÖRÜLEN OSTEONEKROZ VAKALARININ MEDİKAL VE CERRAHİ TEDAVİLERİ SONRASI UZUN DÖNEM TAKİPLERİ. Ata Diş Hek Fak Derg. 2019;29(1):89-97.

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