Review
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CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW

Year 2019, Volume: 29 Issue: 2, 332 - 339, 22.03.2019
https://doi.org/10.17567/ataunidfd.282165

Abstract

ABSTRACT







Hypodontia is defined as the
congenital deficiency of one or more teeth and is one of the most common dental
anomalies in humans. Multifactorial etiology can include environmental factors
as well, since a combination of environmental and genetic factors might
contribute to the occurrence of dental agenesis. Patient with missing teeth;
reduced masticatory ability, inarticulate pronunciation may encounter esthetics
and periodontal problems. Tooth agenesis definition, etiology, genes that cause
tooth agenesis and treatment of tooth agenesis is mentioned in this review.
Nowadays, many genes which play role in tooth development reported to be a
potential candidate gene in tooth agenesis. Functional changes seen in genes
which play role in tooth agenesis are mentioned that there may be a
relationship with the development of cancer and tooth agenesis may be a
significant marker for cancer.



Key Words: Hypodontia, prevalence, neoplasms




Diş Eksikliğinde Güncel Yaklaşımlar: Derleme



ÖZ




           

Hipodonti, bir veya daha fazla dişin konjenital
eksikliği olarak tanımlanır ve insanlarda en sık görülen dental anomalilerden
biridir. Genetik faktörlerin yanısıra çevresel faktörler veya bunların
kombinasyonu diş eksikliklerinin görülmesine sebep olabilmektedir. Eksik
dişlere sahip hastalar; azalmış çiğneme yeteneği, telaffuzun anlaşılamaması,
estetik ve periodontal problemlerle karşılaşabilmektedir.
Bu derlemede konjenital diş eksikliği tanımı, etiyolojisi, diş eksikliğine
sebep olan genler ve tedavisinden bahsedilmektedir. Günümüzde, diş
gelişiminde rol alan birçok genin, diş eksikliğinde de potansiyel aday
genler oldukları bildirilmektedir.
Diş eksikliğinde rol alan genlerde görülen fonksiyonel değişikliklerin
kanser gelişimiyle bir ilişkisi olabileceğinden ve diş eksikliğinin kanser için
belirleyici bir marker olabileceğinden bahsedilmektedir
.



Anahtar
Sözcükler:
Hipodonti, prevalans, tümörler

References

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Year 2019, Volume: 29 Issue: 2, 332 - 339, 22.03.2019
https://doi.org/10.17567/ataunidfd.282165

Abstract

References

  • 1. Bailleul-Forestier I, Molla M, Verloes A, Berdal A. The genetic basis of inherited anomalies of the teeth. Part 1: clinical and molecular aspects of non-syndromic dental disorders. Eur J Med Genet 2008; 51: 273-291.
  • 2. Arte S. Phenotypic and genotypic features of familial hypodontia. Department of Pedodontics and Orthodontics Helsinki, Finland University of Helsinki 2001: 12-14.
  • 3. Polder BJ, Van't Hof MA, Van der Linden FP, Kuijpers-Jagtman AM. A meta-analysis of the prevalence of dental agenesis of permanent teeth. Community Dent Oral Epidemiol 2004; 32: 217-226.
  • 4. Shimizu T, Maeda T. Prevalence and genetic basis of tooth agenesis. Jpn Dentl Sci Rev 2009; 45: 52-58.
  • 5. Nordgarden H, Jensen JL, Storhaug K. Reported prevalence of congenitally missing teeth in two Norwegian counties. Community Dent Health 2002; 19: 258-61.
  • 6. Fekonja A. Hypodontia in orthodontically treated children. Eur J Orthod 2005; 27: 457–60.
  • 7. Abed Al Jawad FH, Al Yafei H, Al Sheeb M, Al Emadi B, Al Hashimi N. Hypodontia prevalance and distribution pattern in a group of Qatari orthodontic and pediatric patients: A retrospective study. Eur J Dent 2015; 9: 267-71.
  • 8. Hashim HA, Al-Said S. The prevalance and distribution of hypodontia in a sample of Qatari patients. J Orthod Sci 2016; 5: 1-6.9. Hassan DA, Abuaffan AH, Hashim HA. Prevalence of hypodontia in a sample of Sudanese orthodontic patients. J Orthod Sci. 2014; 3: 63-7.
  • 9. Hassan DA, Abuaffan AH, Hashim HA. Prevalance of hypodontia in a sample of Sudanese orthodontic patients. J Orthod Sci 2014; 3: 63-7.
  • 10. Altuğ A, Erdem D. Prevalence and distribution of dental anomalies in orthodontic patients. Am J Orthod Dentofacial Orthop 2007; 131: 510-514.
  • Aren G, Güven Y, Tolgay CG, Özcan İ, Bayar ÖF et al. The prevalence of dental anomalies in a Turkish population. J Istanbul Univ Fac Dent 2015; 49: 23-28.
  • 12. Uslu O, Akcam MO, Evirgen S, Cebeci İ. Prevalence of dental anomalies in various malocclusions. Am J Orthod Dentofacial Orthop 2007; 135: 328-335.
  • 13. Celikoglu M, Kazanci F, Miloglu O, Oztek O, Kamak H, Ceylan I. Frequency and characteristics of tooth agenesis among an orthodontic patient population. Med Oral Patol Oral Cir Bucal 2010, 15: 797-801.
  • 14. Ezirganlı Ş, Köşger H, Özer K, Kırtay M, Ün E. Prevalence Of Congenİtally Missing Second Premolars. Cumhuriyet Dent J 2010, 13: 48-51.
  • 15. Kazanci F, Celikoglu M, Miloglu O, Ceylan I, Karmak H. Frequency and distribution of developmental anomalies in the permanent teeth of a Turkish orthodontic patient population. J Dent Sci 2011; 6: 82-89.
  • 16. Candan Ü, Kıpçak Ö, Evcil MS. Prevalance of congenitaly missing permanent teeth in Aegean region children. Atatürk Univ Fac Dent J. 2014; 24: 349-352.
  • 17. Goya HA, Tanaka S, Maeda T, Akimoto Y. An orthopantomographic study of hypodontia in permanent teeth of Japanese pediatric patients. J Oral Sci 2008; 50: 143-150.
  • 18. Behr M, Proff P, Leitzmann M, Pretzel M, Handel G, Schmalz G. Survey of congenitally missing teeth in orthodontic patients in Eastern Bavaria. Eur J Orthod 2010; 5: 32-33.
  • 19. Lyngstadaas SP, Nordbo H, Gedde-Dahl T Jr, Thrane PS. On the genetics of hypodontia and microdontia: Synergism or allelism of major genes in a family with six affected members. J Med Genet 1996; 33: 137–142.
  • 20. Cobourne MT. Familial human hypodontia is it all in the genes? Br Dent J 2007; 203: 203-208.
  • 21.AlShahrani I, Togoo RA, AlQarni MA. A Review of Hypodontia: Classification, Prevalence, Etiology, Associated Anomalies, Clinical Implications and Treatment Options. World J Dent 2013; 4: 117- 125.
  • 22. Marec-Berard P, Azzi D, Chaux-Bodard AG, Lagrange H, Gourmet R, Bergeron C. Long-term effects of chemotherapy on dental status in children treated for nephroblastoma. Pediatr Hematol Oncol 2005; 22: 581–588.
  • 23. Keller JM, Huet-Hudson YM, Leamy LJ. Qualitative effects of dioxin on molars vary among inbred mouse strains. Arch Oral Biol 2007; 52: 450–454.
  • 24. Yamaguchi T, Tomoyasu Y, Nakadate T, Oguchi K, Maki K. Allergy as a possible predisposing factor for hypodontia. Eur J Orthod 2008; 30: 641– 644.
  • 25. Parkin N, Elcock C, Smith RN, Griffin RC, Brook AH. The aetiology of hypodontia: the prevalence, severity and location of hypodontia within families. Arch Oral Biol 2009; 54: 52-56.
  • 26. Pedersen LB, Clausen N, Schrøder H, Schmidt M, Poulsen S. Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy. Int J Paediatr Dent 2012; 22: 239–243.
  • 27. Lammi L, Arte S, Somer M, Jarvinen H, Paivi L, Thesleff I et al. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet 2004; 74: 1043-1050.
  • 28. Kantaputra P, Sripathomsawat W. WNT10A and isolated hypodontia. Am J Med Genet 2011; 155: 1119–1122.
  • 29. Brook AH, Elcock C, Aggarwal M, Lath DL, Russel JM, Patel PI, Smith RN. Tooth dimensions in hypodontia with a known PAX-9 mutation. Arch Oral Biol 2009; 54: 57-62.
  • 30. Townsend G, Hughes T, Luciano M, Bockmann M, Brook A. Genetic and environmental influences on human dental variation: A critical evaluation of studies involving twins. Arch Oral Biol 2009; 54: 45-51.
  • 31. Townsend G, Alvesalo L, Brook A. Variation in the Human Dentition: Some Past Advances and Future Opportunities. J Dent Res 2008; 87: 802-805.
  • 32. Boeira Br Jr, Echeverrıgaray S. Novel missense mutation in PAX9 gene associated with familial tooth agenesis. J Oral Pathol Med 2013; 42: 99–105.
  • 33. Mostowska A, Zadurska M, Rakowska A, Lianeri M, Jagodzinski PP. Novel PAX9 mutation associated with syndromic tooth agenesis. Eur J Oral Sci 2013; 121: 403–411.
  • 34. Mitsiadis TA, Luder HU. Genetic basis for tooth malformations: from mice to men and back again. Clin Genet 2011; 80: 319-329.
  • 35. Shimizu T, Morita W, Maeda T. Genetic mapping of agenesis of the third molars in mice. Biochem Genet 2013; 51: 728–736.
  • 36. Henningsen E, Svendsen MT, Lildballe DL, Jensen PK. A novel mutation in the EDAR gene causes severe autosomal recessive hypohidrotic ectodermal dysplasia. Am J Med Genet 2014; 164: 2059–2061.
  • 37. Rauch T, Li H, Wu X, Pfeifer GP. Mira-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identi es frequent methylation of homeodomain containing genes in lung cancer cells. Cancer Res 2006; 66: 7939-7947.
  • 38. Coudert AE, Pibouin L, Vi-Fane B, Thomas BL, Macdougall M, Choudhury A. Expression and regulation of the Msx1 natural antisense transcript during development. Nucleic Acids Res 2005; 33: 5208-5218.
  • 39. Ogawa T, Kapadia H, Wang B, D'Souza RN. Studies on Pax9-Msx1 protein interactions. Arch Oral Biol 2005; 50: 141-145.
  • 40. Nakatomi M, Wang XP, Key D, Lund JJ, Turbe-Doan A, Kist R. Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev Biol 2010; 340: 438-449.
  • Prager TM, Finke C, Miethke RR. Dental findings in patients with ectodermal dysplasia. J Orofac Orthop 2006; 67: 347-355.
  • 42. Vogelaar IP, Figueiredo J, van Rooij IA. Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts. Hum Mol Genet 2013; 22: 919–926.
  • 43. Lejeune S, Guillemot F, Triboulet JP. Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. Hum Mutat 2006; 27: 1064.
  • 44. Lindor NM, Win AK, Gallinger S. Colorectal cancer and self-reported tooth agenesis. Hered Cancer Clin Pract 2014; 12: 7.
  • 45. Marvin ML, Mazzoni SM, Herron CM, Edwards S, Gruber SB, Petty EM. AXIN2-associated autosomal dominant ectodermal dysplasia and neoplastic syndrome. Am J Med Genet 2011; 155: 898–902.
  • 46. Bonds J, Pollan-White S, Xiang L, Mues G, D’Souza R. Is there a link between ovarian cancer and tooth agenesis. Eur J Med Genet 2014; 57: 235–239.
  • 47. Cobourne MT, Sharpe PT. Tooth and jaw: molecular mechanisms of patterning in the first branchial arch. Arch Oral Biol 2003; 48: 1-14.
  • 48. Ada H, Alan FS, Joanna SA, Carol AB, Victor AM. A knowledgebase of human genes and genetic disorders. OMIM 2005; 33: 514-517.
  • 49. Bural C, Oztas E, Ozturk S, Bayraktar G. Multidisciplinary treatment of nonsyndromic oligodontia. Eur J Dent 2012; 6: 218–226.
  • 50. Mikulás K, Kivovics P, Nagy G, Márton K, Madléna M. Complex oral rehabilitation of a patient with Witkop's syndrome: an interdisciplinary approach. Oral health Dent Manage Black Sea Ctries. 2008; 7: 56–60.
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There are 81 citations in total.

Details

Primary Language English
Subjects Dentistry
Journal Section Derleme
Authors

Özge Şentürk

Kadriye Görkem Ulu Güzel This is me

Publication Date March 22, 2019
Published in Issue Year 2019 Volume: 29 Issue: 2

Cite

APA Şentürk, Ö., & Ulu Güzel, K. G. (2019). CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 29(2), 332-339. https://doi.org/10.17567/ataunidfd.282165
AMA Şentürk Ö, Ulu Güzel KG. CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW. Ata Diş Hek Fak Derg. March 2019;29(2):332-339. doi:10.17567/ataunidfd.282165
Chicago Şentürk, Özge, and Kadriye Görkem Ulu Güzel. “CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29, no. 2 (March 2019): 332-39. https://doi.org/10.17567/ataunidfd.282165.
EndNote Şentürk Ö, Ulu Güzel KG (March 1, 2019) CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29 2 332–339.
IEEE Ö. Şentürk and K. G. Ulu Güzel, “CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW”, Ata Diş Hek Fak Derg, vol. 29, no. 2, pp. 332–339, 2019, doi: 10.17567/ataunidfd.282165.
ISNAD Şentürk, Özge - Ulu Güzel, Kadriye Görkem. “CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29/2 (March 2019), 332-339. https://doi.org/10.17567/ataunidfd.282165.
JAMA Şentürk Ö, Ulu Güzel KG. CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW. Ata Diş Hek Fak Derg. 2019;29:332–339.
MLA Şentürk, Özge and Kadriye Görkem Ulu Güzel. “CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, vol. 29, no. 2, 2019, pp. 332-9, doi:10.17567/ataunidfd.282165.
Vancouver Şentürk Ö, Ulu Güzel KG. CURRENT APPROACHES FOR TOOTH AGENESIS: A REVIEW. Ata Diş Hek Fak Derg. 2019;29(2):332-9.

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