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REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA

Year 2019, Volume: 29 Issue: 2, 229 - 237, 22.03.2019
https://doi.org/10.17567/ataunidfd.526953

Abstract




ABSTRACT




Aim: The aim of this
study was to compare the extent of remineralization of permanent molar enamel
with application of three remineralizing agents by employing QLF, microhardness
and microcomputed tomography machine values.




materials
and Methods:
An in vitro
study was performed with 12 sound permanent molar teeth. The teeth were split
in mesio-distal direction and two samples were obtained from each tooth (n=8).
An artificial caries lesion (2x4 mm) was produced on enamel surfaces of sound
molars using a previously reported demineralization model. Specimens were
randomly divided into three groups: first group was treated using Tooth Mousse
Plus (GC), the
second group was treated using Clinpro Tooth Crème (3M ESPE) and the last group
was treated using Sensodyne Protection and Repair (GSK).
Demineralizing, remineralizing solutions and the tooth pastes were respectively applied
the groups over a period of 14 days.
The samples were subjected to QLF, microhardness,
micro-computed tomography machine and electron microscope scanning.




Results: As compared with demineralization and remineralization values, in Tooth
Mousse Plus group, micro-computed tomography showed no statistically
significant difference (p>0,05) but QLF and micro hardness machines showed
statistically significant difference (p<0,05). In Clinpro Tooth Crème and
Sensodyne Repair and Protect groups; micro computed tomography, QLF and
microhardness machines showed statistically significant difference (p>0,05).




Conclusion: Tooth Mousse Plus, Clinpro Tooth Crème
and Sensodyne Repair and Protection are appropriated means of treating caries
at early stages.




Keywords: Reminalization,
CPP-ACP,
micro-computed
tomography, microhardness, QLF
 




BAŞLANGIÇ ÇÜRÜKLERİNDE
REMİNERALİZE EDİCİ AJANLARIN ETKİSİNİN ÇEŞİTLİ DİAGNOSTİK YÖNTEMLERLE KARŞILAŞTIRILMASI
VE YÜZEY SERTLİKLERİNİN DEĞERLENDİRİLMESİ




ÖZ




Amaç: Bu
çalışmanın amacı daimi molar dişlere uygulanan üç remineralize edici ajanın
etkilerinin QLF, mikrosertlik ve milrobilgisayarlı tomografı cihazları ile elde
edilen değerlerin karşılaştırılmasıdır.




Gereç ve yöntem: Bu in vitro çalışmada sağlam 12 adet daimi
molar diş kullanıldı. Dişler mezio-distal yönde ikiye ayrıldı (n=8). Yapay
çürük lezyonu (2x4 mm) sağlıklı dişlerin minesinde deminalizasyon döngüsü ile
oluşturuldu. Dişler rastgele 3 eşit gruba ayrıldı. 1. gruba
Tooth Mousse Plus
(GC), 2. gruba Clinpro Tooth Crème (3M ESPE) ve 3. gruba Sensodyne Onarım ve
Koruma (GSK) uygulandı. 14 gün boyunca demineralizasyon, remineralizasyon
solüsyonları ve diş macunları sırasıyla gruplara uygulandı. Numuneler QLF,
mikrosertlik, mikrobilgisayarlı tomografi cihazları ile ölçüldü ve elektron
mikroskobuyla değerlendirildi.




Bulgular: Tooth Mousse Plus
uygulanan grupta demineralizasyon ve remineralizasyon değerleri
kıyaslandığında, mikrobilgisayarlı tomografi istatistiksel olarak anlamlı
bulunmamıştır
(p>0,05) fakat QLF ve mikrosertlik cihazlarının
değerleri istatistiksel olarak anlamlı bulunmuştur (p<0,05).
Clinpro Tooth
Crème ve Sensodyne Onarım ve Koruma uygulanan gruplarda; mikrobilgisayarlı
tomografi, QLF ve mikrosertlik değerleri istatistiksel olarak anlamlı
bulunmamıştır
(p>0,05).




Sonuç: Tooth Mousse Plus,
Clinpro Tooth
Crème
and Sensodyne Onarım ve Koruma erken dönem çürüklerin tedavisinde
kullanılabilir.




Anahtar
kelimeler:

Remineralizasyon, CPP-ACP, mikrobilgisayarlı tomografi, mikrosertlik, QLF




References

  • 1. Alhawij H, Lippert F, and Martinez-Mier EA. Relative fluoride response of caries lesions created in fluorotic and sound teeth studied under remineralizing conditions. J Dent 2015;43(1):103-109.
  • 2. Amaechi BT and Ramalingam K. Evaluation of fluorescence imaging with reflectance enhancement technology for early caries detection. Am J Dent 2014;27(2):111-116.
  • 3. Balakrishnan A, Jonathan R, Benin P, and Kuumar A. Evaluation to determine the caries remineralization potential of three dentifrices: An in vitro study. J Conserv Dent 2013;16(4):375-379.
  • 4. Borsatto MC, Corona SA, Dibb RG, Ramos RP, and Pecora JD. Microleakage of a resin sealant after acid-etching, Er:YAG laser irradiation and air-abrasion of pits and fissures. J Clin Laser Med Surg 2001;19(2):83-87.
  • 5. Burwell AK, Litkowski LJ, and Greenspan DC. Calcium sodium phosphosilicate (NovaMin): remineralization potential. Adv Dent Res 2009;21(1):35-9.
  • 6. Buzalaf MA, Hannas AR, Magalhaes AC, Rios D, Honorio HM, and Delbem AC. pH-cycling models for in vitro evaluation of the efficacy of fluoridated dentifrices for caries control: strengths and limitations. J Appl Oral Sci, 2010;18(4):316-334.
  • 7. Cochrane NJ, Walker GD, Manton DJ, and Reynolds EC. Comparison of quantitative light-induced fluorescence, digital photography and transverse microradiography for quantification of enamel remineralization. Aust Dent J 2012;57(3):271-276.
  • 8. Dalli M, Colak H, and Mustafa Hamidi M. Minimal intervention concept: a new paradigm for operative dentistry. J Investig Clin Dent 2012;3(3):167-175.
  • 9. De Munck J, Van Landuyt K, Peumans M, Poitevin A, Lambrechts P, Braem M, and Van Meerbeek B. A critical review of the durability of adhesion to tooth tissue: methods and results. J Dent Res 2005;84(2):118-32.
  • 10. Elkassas D and Arafa A. Remineralizing efficacy of different calcium-phosphate and fluoride based delivery vehicles on artificial caries like enamel lesions. J Dent 2014;42(4):466-474.
  • 11. Forss H and Widstrom E. Reasons for restorative therapy and the longevity of restorations in adults. Acta Odontol Scand 2004;62(2):82-86.
  • 12. Gomez J, Pretty IA, Santarpia RP, 3rd, Cantore B, Rege A, Petrou I, and Ellwood RP. Quantitative light-induced fluorescence to measure enamel remineralization in vitro. Caries Res 2014;48(3):223-227.
  • 13. Lippert F and Juthani K. Fluoride dose-response of human and bovine enamel artificial caries lesions under pH-cycling conditions Clin Oral Investig 2015;19(8),1947-1954.
  • 14. Lo EC, Zhi QH, and Itthagarun A. Comparing two quantitative methods for studying remineralization of artificial caries. J Dent 2010;38(4):352-9.
  • 15. Lv X, Yang Y, Han S, Li D, Tu H, Li W, Zhou X, and Zhang L (). Potential of an amelogenin based peptide in promoting reminerlization of initial enamel caries. Arch Oral Biol 2015;60(10):1482-1487.
  • 16. Lynch RJ. Model parameters and their influence on the outcome of in vitro demineralisation and remineralisation studies. Monogr Oral Sci 2006;19:65-85.
  • 17. Marcenes W, Kassebaum NJ, Bernabe E, Flaxman A, Naghavi M, Lopez A, and Murray CJ. Global burden of oral conditions in 1990-2010: a systematic analysis. J Dent Res 2013; 92(7):592-597.
  • 18. Malekafzali B, Ekrami M, Mirfasihi A, and Abdolazimi Z. Remineralizing Effect of Child Formula Dentifrices on Artificial Enamel Caries Using a pH Cycling Model. J Dent (Tehran) 2015;12(1):11-7.
  • 19. Mehta R, Nandlal B, and Prashanth S. Comparative evaluation of remineralization potential of casein phosphopeptide-amorphous calcium phosphate and casein phosphopeptide-amorphous calcium phosphate fluoride on artificial enamel white spot lesion: an in vitro light fluorescence study. Indian J Dent Res 2013;24(6):681-9.
  • 20. Mitropoulos P, Rahiotis C, Stamatakis H, and Kakaboura A. Diagnostic performance of the visual caries classification system ICDAS II versus radiography and micro-computed tomography for proximal caries detection: an in vitro study. J Dent 2010;38(11):859-867.
  • 21. Mohanty P, Padmanabhan S, and Chitharanjan AB. An in Vitro Evaluation of Remineralization Potential of Novamin((R)) on Artificial Enamel Sub-Surface Lesions Around Orthodontic Brackets Using Energy Dispersive X-Ray Analysis (EDX). J Clin Diagn Res 2014;8(11):ZC88-91.
  • 22. Newbrun E. Preventing dental caries: breaking the chain of transmission. J Am Dent Assoc 1992;123(6):55-59.
  • 23. Nithila A, Bourgeois D, Barmes DE, and Murtomaa H. WHO Global Oral Data Bank, 1986-96: an overview of oral health surveys at 12 years of age. Bull World Health Organ 1998;76(3):237-244.
  • 24. Oliveira GM, Ritter AV, Heymann HO, Swift E, Jr., Donovan T, Brock G, and Wright T. Remineralization effect of CPP-ACP and fluoride for white spot lesions in vitro. J Dent 201442(12):1592-1602.
  • 25. Pardi V, Sinhoreti MA, Pereira AC, Ambrosano GM, and Meneghim Mde C. In vitro evaluation of microleakage of different materials used as pit-and-fissure sealants. Braz Dent J 2006;17(1):49-52.
  • 26. Pretty IA, Edgar WM and Higham SM. A review of the effectiveness of quantitative light-induced fluorescence (QLF) to detect early caries. Early Detection of Dental Caries III: Proceedings of the 6th Indiana Conference. Indianapolis, Ind: Indiana University School of Dentistry. 2003.
  • 27. Reynolds EC. Calcium phosphate-based remineralization systems: scientific evidence? Aust Dent J 200853(3):268-273.
  • 28. Rirattanapong P, Vongsavan K, Saengsirinavin C, and Pornmahala T. Effect of Fluoride Varnishes Containing Different Calcium Phosphate Sources on Mineralization of Initial Primary Enamel Lesions. Southeast Asian J Trop Med Public Health, 2014;45(6):1503-1510.
  • 29. Roberson TM HH, Swift EJ. Sturdevant's Art and Science of Operative Dentistry. 5 ed. St.Louis: Mosby Co. 2011;67-134.
  • 30. Shen P, Manton DJ, Cochrane NJ, Walker GD, Yuan Y, Reynolds C, and Reynolds EC. Effect of added calcium phosphate on enamel remineralization by fluoride in a randomized controlled in situ trial. J Dent, 2011;39(7):518-525.
  • 31. Shetty S, Hegde MN, and Bopanna TP. Enamel remineralization assessment after treatment with three different remineralizing agents using surface microhardness: An in vitro study. J Conserv Dent 2014;17(1):49-52.
  • 32. Soderstrom U, Johansson I, and Sunnegardh-Gronberg K. A retrospective analysis of caries treatment and development in relation to assessed caries risk in an adult population in Sweden. BMC Oral Health 2014;14(1):126.
  • 33. Somasundaram P, Vimala N, and Mandke LG. Protective potential of casein phosphopeptide amorphous calcium phosphate containing paste on enamel surfaces. J Conserv Dent 2013;16(2):152-156.
  • 34. Soviero VM, Leal SC, Silva RC, and Azevedo RB. Validity of MicroCT for in vitro detection of proximal carious lesions in primary molars. J Dent 2012;40(1):35-40.
  • 35. Stookey GK, Featherstone JD, Rapozo-Hilo M, Schemehorn BR, Williams RA, Baker RA, Barker ML, Kaminski MA, McQueen CM, Amburgey JS, Casey K, and Faller RV. The Featherstone laboratory pH cycling model: a prospective, multi-site validation exercise. Am J Dent 2011;24(5):322-328.
  • 36. Sunnegardh-Gronberg K, van Dijken JW, Funegard U, Lindberg A, and Nilsson M. Selection of dental materials and longevity of replaced restorations in Public Dental Health clinics in northern Sweden. J Dent2009;37(9):673-678.
  • 37. Vanichvatana S and Auychai P. Efficacy of two calcium phosphate pastes on the remineralization of artificial caries: a randomized controlled double-blind in situ study. Int J Oral Sci 2013;5(4):224-228.
  • 38. Wierichs RJ, Zelck H, Doerfer CE, Appel P, Paris S, Esteves-Oliveira M, and Meyer-Lueckel H. Effects of dentifrices differing in fluoride compounds on artificial enamel caries lesions in vitro. Odontology 2017;105(1),36-45.
  • 39. Zhang X, Li Y, Sun X, Kishen A, Deng X, Yang X, Wang H, Cong C, Wang Y, and Wu M. Biomimetic remineralization of demineralized enamel with nano-complexes of phosphorylated chitosan and amorphous calcium phosphate. J Mater Sci Mater Med 2014;25(12):2619-2628.
Year 2019, Volume: 29 Issue: 2, 229 - 237, 22.03.2019
https://doi.org/10.17567/ataunidfd.526953

Abstract

References

  • 1. Alhawij H, Lippert F, and Martinez-Mier EA. Relative fluoride response of caries lesions created in fluorotic and sound teeth studied under remineralizing conditions. J Dent 2015;43(1):103-109.
  • 2. Amaechi BT and Ramalingam K. Evaluation of fluorescence imaging with reflectance enhancement technology for early caries detection. Am J Dent 2014;27(2):111-116.
  • 3. Balakrishnan A, Jonathan R, Benin P, and Kuumar A. Evaluation to determine the caries remineralization potential of three dentifrices: An in vitro study. J Conserv Dent 2013;16(4):375-379.
  • 4. Borsatto MC, Corona SA, Dibb RG, Ramos RP, and Pecora JD. Microleakage of a resin sealant after acid-etching, Er:YAG laser irradiation and air-abrasion of pits and fissures. J Clin Laser Med Surg 2001;19(2):83-87.
  • 5. Burwell AK, Litkowski LJ, and Greenspan DC. Calcium sodium phosphosilicate (NovaMin): remineralization potential. Adv Dent Res 2009;21(1):35-9.
  • 6. Buzalaf MA, Hannas AR, Magalhaes AC, Rios D, Honorio HM, and Delbem AC. pH-cycling models for in vitro evaluation of the efficacy of fluoridated dentifrices for caries control: strengths and limitations. J Appl Oral Sci, 2010;18(4):316-334.
  • 7. Cochrane NJ, Walker GD, Manton DJ, and Reynolds EC. Comparison of quantitative light-induced fluorescence, digital photography and transverse microradiography for quantification of enamel remineralization. Aust Dent J 2012;57(3):271-276.
  • 8. Dalli M, Colak H, and Mustafa Hamidi M. Minimal intervention concept: a new paradigm for operative dentistry. J Investig Clin Dent 2012;3(3):167-175.
  • 9. De Munck J, Van Landuyt K, Peumans M, Poitevin A, Lambrechts P, Braem M, and Van Meerbeek B. A critical review of the durability of adhesion to tooth tissue: methods and results. J Dent Res 2005;84(2):118-32.
  • 10. Elkassas D and Arafa A. Remineralizing efficacy of different calcium-phosphate and fluoride based delivery vehicles on artificial caries like enamel lesions. J Dent 2014;42(4):466-474.
  • 11. Forss H and Widstrom E. Reasons for restorative therapy and the longevity of restorations in adults. Acta Odontol Scand 2004;62(2):82-86.
  • 12. Gomez J, Pretty IA, Santarpia RP, 3rd, Cantore B, Rege A, Petrou I, and Ellwood RP. Quantitative light-induced fluorescence to measure enamel remineralization in vitro. Caries Res 2014;48(3):223-227.
  • 13. Lippert F and Juthani K. Fluoride dose-response of human and bovine enamel artificial caries lesions under pH-cycling conditions Clin Oral Investig 2015;19(8),1947-1954.
  • 14. Lo EC, Zhi QH, and Itthagarun A. Comparing two quantitative methods for studying remineralization of artificial caries. J Dent 2010;38(4):352-9.
  • 15. Lv X, Yang Y, Han S, Li D, Tu H, Li W, Zhou X, and Zhang L (). Potential of an amelogenin based peptide in promoting reminerlization of initial enamel caries. Arch Oral Biol 2015;60(10):1482-1487.
  • 16. Lynch RJ. Model parameters and their influence on the outcome of in vitro demineralisation and remineralisation studies. Monogr Oral Sci 2006;19:65-85.
  • 17. Marcenes W, Kassebaum NJ, Bernabe E, Flaxman A, Naghavi M, Lopez A, and Murray CJ. Global burden of oral conditions in 1990-2010: a systematic analysis. J Dent Res 2013; 92(7):592-597.
  • 18. Malekafzali B, Ekrami M, Mirfasihi A, and Abdolazimi Z. Remineralizing Effect of Child Formula Dentifrices on Artificial Enamel Caries Using a pH Cycling Model. J Dent (Tehran) 2015;12(1):11-7.
  • 19. Mehta R, Nandlal B, and Prashanth S. Comparative evaluation of remineralization potential of casein phosphopeptide-amorphous calcium phosphate and casein phosphopeptide-amorphous calcium phosphate fluoride on artificial enamel white spot lesion: an in vitro light fluorescence study. Indian J Dent Res 2013;24(6):681-9.
  • 20. Mitropoulos P, Rahiotis C, Stamatakis H, and Kakaboura A. Diagnostic performance of the visual caries classification system ICDAS II versus radiography and micro-computed tomography for proximal caries detection: an in vitro study. J Dent 2010;38(11):859-867.
  • 21. Mohanty P, Padmanabhan S, and Chitharanjan AB. An in Vitro Evaluation of Remineralization Potential of Novamin((R)) on Artificial Enamel Sub-Surface Lesions Around Orthodontic Brackets Using Energy Dispersive X-Ray Analysis (EDX). J Clin Diagn Res 2014;8(11):ZC88-91.
  • 22. Newbrun E. Preventing dental caries: breaking the chain of transmission. J Am Dent Assoc 1992;123(6):55-59.
  • 23. Nithila A, Bourgeois D, Barmes DE, and Murtomaa H. WHO Global Oral Data Bank, 1986-96: an overview of oral health surveys at 12 years of age. Bull World Health Organ 1998;76(3):237-244.
  • 24. Oliveira GM, Ritter AV, Heymann HO, Swift E, Jr., Donovan T, Brock G, and Wright T. Remineralization effect of CPP-ACP and fluoride for white spot lesions in vitro. J Dent 201442(12):1592-1602.
  • 25. Pardi V, Sinhoreti MA, Pereira AC, Ambrosano GM, and Meneghim Mde C. In vitro evaluation of microleakage of different materials used as pit-and-fissure sealants. Braz Dent J 2006;17(1):49-52.
  • 26. Pretty IA, Edgar WM and Higham SM. A review of the effectiveness of quantitative light-induced fluorescence (QLF) to detect early caries. Early Detection of Dental Caries III: Proceedings of the 6th Indiana Conference. Indianapolis, Ind: Indiana University School of Dentistry. 2003.
  • 27. Reynolds EC. Calcium phosphate-based remineralization systems: scientific evidence? Aust Dent J 200853(3):268-273.
  • 28. Rirattanapong P, Vongsavan K, Saengsirinavin C, and Pornmahala T. Effect of Fluoride Varnishes Containing Different Calcium Phosphate Sources on Mineralization of Initial Primary Enamel Lesions. Southeast Asian J Trop Med Public Health, 2014;45(6):1503-1510.
  • 29. Roberson TM HH, Swift EJ. Sturdevant's Art and Science of Operative Dentistry. 5 ed. St.Louis: Mosby Co. 2011;67-134.
  • 30. Shen P, Manton DJ, Cochrane NJ, Walker GD, Yuan Y, Reynolds C, and Reynolds EC. Effect of added calcium phosphate on enamel remineralization by fluoride in a randomized controlled in situ trial. J Dent, 2011;39(7):518-525.
  • 31. Shetty S, Hegde MN, and Bopanna TP. Enamel remineralization assessment after treatment with three different remineralizing agents using surface microhardness: An in vitro study. J Conserv Dent 2014;17(1):49-52.
  • 32. Soderstrom U, Johansson I, and Sunnegardh-Gronberg K. A retrospective analysis of caries treatment and development in relation to assessed caries risk in an adult population in Sweden. BMC Oral Health 2014;14(1):126.
  • 33. Somasundaram P, Vimala N, and Mandke LG. Protective potential of casein phosphopeptide amorphous calcium phosphate containing paste on enamel surfaces. J Conserv Dent 2013;16(2):152-156.
  • 34. Soviero VM, Leal SC, Silva RC, and Azevedo RB. Validity of MicroCT for in vitro detection of proximal carious lesions in primary molars. J Dent 2012;40(1):35-40.
  • 35. Stookey GK, Featherstone JD, Rapozo-Hilo M, Schemehorn BR, Williams RA, Baker RA, Barker ML, Kaminski MA, McQueen CM, Amburgey JS, Casey K, and Faller RV. The Featherstone laboratory pH cycling model: a prospective, multi-site validation exercise. Am J Dent 2011;24(5):322-328.
  • 36. Sunnegardh-Gronberg K, van Dijken JW, Funegard U, Lindberg A, and Nilsson M. Selection of dental materials and longevity of replaced restorations in Public Dental Health clinics in northern Sweden. J Dent2009;37(9):673-678.
  • 37. Vanichvatana S and Auychai P. Efficacy of two calcium phosphate pastes on the remineralization of artificial caries: a randomized controlled double-blind in situ study. Int J Oral Sci 2013;5(4):224-228.
  • 38. Wierichs RJ, Zelck H, Doerfer CE, Appel P, Paris S, Esteves-Oliveira M, and Meyer-Lueckel H. Effects of dentifrices differing in fluoride compounds on artificial enamel caries lesions in vitro. Odontology 2017;105(1),36-45.
  • 39. Zhang X, Li Y, Sun X, Kishen A, Deng X, Yang X, Wang H, Cong C, Wang Y, and Wu M. Biomimetic remineralization of demineralized enamel with nano-complexes of phosphorylated chitosan and amorphous calcium phosphate. J Mater Sci Mater Med 2014;25(12):2619-2628.
There are 39 citations in total.

Details

Primary Language English
Subjects Dentistry
Journal Section Araştırma Makalesi
Authors

Engin Kariper This is me 0000-0001-8196-6760

E. Gülşah Göktolga Akın This is me 0000-0001-9183-4032

Oğuzhan Alıcı 0000-0001-5854-6805

Publication Date March 22, 2019
Published in Issue Year 2019 Volume: 29 Issue: 2

Cite

APA Kariper, E., Göktolga Akın, E. G., & Alıcı, O. (2019). REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 29(2), 229-237. https://doi.org/10.17567/ataunidfd.526953
AMA Kariper E, Göktolga Akın EG, Alıcı O. REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA. Ata Diş Hek Fak Derg. March 2019;29(2):229-237. doi:10.17567/ataunidfd.526953
Chicago Kariper, Engin, E. Gülşah Göktolga Akın, and Oğuzhan Alıcı. “REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29, no. 2 (March 2019): 229-37. https://doi.org/10.17567/ataunidfd.526953.
EndNote Kariper E, Göktolga Akın EG, Alıcı O (March 1, 2019) REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29 2 229–237.
IEEE E. Kariper, E. G. Göktolga Akın, and O. Alıcı, “REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA”, Ata Diş Hek Fak Derg, vol. 29, no. 2, pp. 229–237, 2019, doi: 10.17567/ataunidfd.526953.
ISNAD Kariper, Engin et al. “REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29/2 (March 2019), 229-237. https://doi.org/10.17567/ataunidfd.526953.
JAMA Kariper E, Göktolga Akın EG, Alıcı O. REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA. Ata Diş Hek Fak Derg. 2019;29:229–237.
MLA Kariper, Engin et al. “REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, vol. 29, no. 2, 2019, pp. 229-37, doi:10.17567/ataunidfd.526953.
Vancouver Kariper E, Göktolga Akın EG, Alıcı O. REMINERALIZATION AGENTS ON EARLY STAGE OF CARIES COMPARISON WITH DIFFERENT DIAGNOSTIC METHODS AND EVALUATE SURFACE HARDNESS OF REMINERALIZATION AREA. Ata Diş Hek Fak Derg. 2019;29(2):229-37.

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