THE LEPTİN LEVELS OF OBESE AND NORMAL WEİGHT ADOLESCENTS WİTH HEALTHY GİNGİVA AND GİNGİVİTİS: EFFECTS OF PERİODONTAL THERAPY ON THE PARAMETERS

Year 2020, Volume: 30 Issue: 2, 226 - 232, 15.04.2020

Meltem Zihni Korkmaz Recep Orbak Sevda Kurt Çağlar Bulut Uncu

https://doi.org/10.17567/ataunidfd.651688

Abstract

Aim: The purpose of our study was to assess the role of leptin, a hormone secreted by adipose tissue, in the association of obesity and periodontal disease.
Material and Methods: Fifty-six adolescents volunteered to participate in this study. The participants were divided into two groups (obese / normal) and each group was then divided into two subgroups (gingivitis / healthy gingiva). All of the adolescents were measured for clinical indexes such as plaque index (PI) and gingival index (GI). Levels of leptin in the gingival crevicular fluid (GCF) samples and serum leptin levels were determined in blood samples by enzyme linked immune sorbent assay (ELISA).
Results: Blood leptin concentration (BLC) was higher in obese subjects than normal weight subjects (p<0.001). Although not statistically significant, BLC was higher in subjects with gingivitis (p=0.68) and decreased after periodontal therapy (p=0.90). GCF leptin concentration (GLC) levels were also higher in subjects with healthy gingiva (p=0.003) and the obese group (p=0.78), and it increased significantly after periodontal therapy (p<0.001). PI was positively correlated with BLC, PI and GI was negatively correlated with GLC, BLC and GLC were negatively correlated.
Conclusion: While the periodontal disease progressed, there was a decrease in GCF leptin concentration and an increase in blood leptin concentration. This observation suggests that leptin may be a protective agent for gingiva. Greater decrease of GCF leptin concentration in obese subjects with gingivitis than in normal weight subjects with gingivitis can be evidence that disease can be more severe in obese subjects.
Key words: Obesity, gingivitis, gingival crevicular fluid

Periodontal Olarak Sağlıklı ve Gingivitisli Obez ve Normal Kilolu Adolesanlarda Leptin Seviyeleri: Periodontal Tedavinin Bu Değerler Üzerine Etkileri
ÖZ
Amaç: Çalışmamızın amacı yağ dokusu tarafından salgılanan bir hormon olan leptinin obezite ve periodontal hastalık ilişkisindeki rolününün değerlendirilmesidir.
Gereç ve Yöntem: Çalışmamıza gönüllü olarak 56 adolesan birey katıldı. Bireyler vücut kitle indeksine göre obez ve normal kilolu olarak iki gruba; her bir grup, kendi arasında gingivitisli ve periodontal sağlıklı dişetine sahip olanlar şeklinde iki alt gruba ayrıldı. Çalışmaya dahil edilen bütün bireylerin plak indeksi (PI) ve gingival indek (GI) gibi klinik indeksleri kaydedildi. Dişeti oluğu sıvısı (DOS) ve kan serumu leptin seviyeleri enzyme linked immune sorbent assay (ELISA) testi ile değerlendirildi.
Bulgular: Obez bireylerin kan leptin konsantrasyonunun (KLK) normal kilolu bireylerin KLK’sından daha yüksek olduğu tespit edildi (p<0.001). İstatistiksel olarak fark olmamasına rağmen gingivitisli bireylerin KLK’sı daha yüksekti (p=0.68) ve periodontal tedaviden sonra azaldı (p=0.90). Dişeti oluğu sıvısı leptin konsantrasyonu (DLK) periodontal sağlıklı dişetine sahip bireylerde (p=0.003) ve obez grupta (p=0.78) daha yüksekti ve periodontal tedavi sonrası istatistiksel anlamlı şekilde arttı (p<0.001). PI, KLK ile pozitif; PI ve GI, DKL ile negatif korelasyon gösterdi. KLK ve DLK arasında ise negatif korelasyon tespit edildi.
Sonuç: Dişetinde sağlıktan hastalığa doğru gidildikçe DLK düşerken, KLK yükselme eğilimi göstermektedir. Bu durum leptinin dişetinde koruyucu bir ajan olabileceğini düşündürmektedir. Obez gingivitisli bireylerde normal kilolu bireylere göre DLK’nun daha çok düşmesi, hastalığın daha ağır seyredebileceğine dair bir kanıt olabilir.
Anahtar Kelimeler: Obezite, Gingivitis, Dişeti oluğu sıvısı

Keywords

Obesity, gingivitis

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