PERİODONTAL ENFEKSİYONUN TEŞHİS VE PROGNOZUNDA UMUT VADEDEN BİYOBELİRTEÇLER

Year 2020, Volume: 30 Issue: 3, 499 - 506, 15.07.2020

Özlem Şahin Ata Yerda Özkan Cenk Fatih Çanakçı

https://doi.org/10.17567/ataunidfd.566916

Abstract

Öz

Periodontal hastalıklar çeşitli
mikroorganizmalar tarafından başlatılmış olsa da, kompleks mikroflorası ve
konak yanıtı periodontal durumu etkilemekte ve sipesifik hastalık
belirteçlerini tanımlamayı zorlaştırmaktadır. Periodontal hastalık tanısında
kullanılan sondalamada kanama, cep derinliği, klinik ataçman seviyesi ve
radyolojik kemik miktarı gibi klinik periodontal parametreler, hastalığın
şiddetinin, prognozunun ve tedaviye verilen yanıtın değerlendirilmesinde
yetersiz kalmaktadır. Bu nedenle, dişeti oluğu sıvısı, tükürük ve serum
öneklerinde tespit edilebilen çeşitli biyobelirteçler bu konuda bize umut ışığı
olmaktadır. Son dönemlerde, doku savunma hücreleri olan adipositlerden salınan ve
adipokinler olarak adlandırılan bazı proteinler rapor edilmiştir. Bu derlemede,
çeşitli periodontal hastalıklarda çalışılmış adipokinler incelenmiş ve
gelecekte adipokinlerin bir biyobelirteç olarak periodontoloji alanında
uygulanabilirliği tartışılmıştır.

Anahtar Kelimeler: Adipokin, Yağ doku, Periodontal
hastalık, biyobelirteç

 PROMISING
BIOMARKERS IN THE DIAGNOSIS AND PROGNOSIS OF PERIODONTAL INFECTION

Abstract

Although periodontal disease is
started by various bacteria, complex microflora and the host response  affects periodontal condition and makes it
difficult to identify specific disease marker. Clinical parameters including
such as bleeding on probing, probing depth, clinical attachment level and
radiographic bone amount which used in the diagnosis of periodontal disease,
are insufficient to evaluate the severity and prognosis of disease and response
to treatment. Therefore,
various biomarkers that can be detected in gingival fluid, saliva and serum
sampels are the light of hope for us. Recently, some proteins, called
adipokines, which have been released from adipocytes as tissue defense cells,
have been reported. In this review, adipokines studied in various periodontal
diseases are investigated and the applicability of adipokines as a biomarker in
the field of periodontology is discussed.

Key Words: Adipokines,
adipose tissue, periodontal disease, biomarkers

Keywords

Adipokin, Yağ doku, Periodontal hastalık

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