FARKLI ETKEN MADDELERE SAHİP DİŞ MACUNLARININ ANTİMİKROBİYAL ETKİNLİĞİNİN İNCELENMESİ

Year 2020, Volume: 30 Issue: 3, 345 - 350, 15.07.2020

Edibe Egil , Özge Ünlü

https://doi.org/10.17567/ataunidfd.706795

Abstract

Amaç: Diş hekimliğinde tedavi ve koruma amaçlı doğal ürünlerden köken alan biyolojik aktif bileşiklere artan ilgi her geçen gün devam etmektedir. Bu çalışmanın amacı farklı etken maddelere sahip bitkisel ve doğal içeriklere sahip diş macunlarının antimikrobiyal etkinliğinin değerlendirilmesidir.
Gereç ve Yöntem: Çalışmada farklı içeriğe sahip dokuz diş macununun (Fluor/500 ppm, Misvak+propolis+çay ağacı, Ganoderma lucidum ekstresi, himalaya tuzu, misvak özlü, Xlylitol, Aleo vera özlü, Ev yapımı) Streptococcus mutans ATCC 25175, Lactobacillus acidophilus ATCC 4356 ve Candida albicans ATCC 10231 kökenlerine karşı antimikrobiyal etkinliği agar difüzyon tekniği ile test edildi. İstatistiksel analizler Mann Whitney U testi ile değerlendirildi.
Bulgular: Test edilen diş macunlarının S.mutans’a karşı antimikrobiyal etkinlikleri incelendiğinde aloe vera özlü diş macununun, test edilen diğer diş macunlarına kıyasla antimikrobiyal etkinliğinin anlamlı olarak daha yüksek olduğu tespit edildi (p<0,05). L. acidophilus’a karşı etkinlikleri incelendiği zaman ise, aleo vera özlü ve ev yapımı diş macunlarının antimikrobiyal etkinliklerinin diğer diş macunlarından istatistiksel olarak anlamlı derecede yüksek olduğu gözlemlenmiştir (p<0,05).
Sonuç: Çalışmamızda incelenen alternatif etken maddeler ile üretilen diş macunlarının in vitro koşullarda antimikrobiyal etkiler gösterebileceği gözlenmiştir. In vitro çalışmaları yapılan diş macunların aktif bileşenlerinin ağız içerisinde, pH üzerine etkisi, tükürükte seyrelmesi sonucu oluşacak antimikrobiyal etkinliğinin değerlendirilmesi adına klinik çalışmalara ihtiyaç duyulmaktadır.
Anahtar kelimeler: diş macunu, fluor, bitkisel diş macunu

Investigation of antimicrobial activity of herbal toothpastes with different active substances
ABSTRACT
Objective: There is increasing interest in biologically active compounds originating from natural products for treatment and protection in dentistry. The aim of this study was to evaluate the antimicrobial efficacy of toothpastes with herbal and natural ingredients with different active ingredients.
Material and Methods: The antimicrobial activity of nine toothpaste (Fluor / 500 ppm, Miswak + propolis + tea tree, Ganoderma lucidum extract, himalaya salt, miswak extract, Xlylitol, Aleo vera extract, Homemade) were tested by agar diffusion technique against the Streptococcus mutans ATCC 25175, Lactobacillus acidophilus ATCC 4356 and Candida albicans ATCC 10231. Mann Whitney U test was used for statistical analysis.
Results: The antimicrobial activity of the tested toothpastes against S.mutans showed that the aloe vera toothpaste had significantly higher antimicrobial efficacy than all toothpastes tested (p <0.05). The antimicrobial activities of aleo vera extract and home-made toothpastes against the L.acidophilus were significantly higher than other toothpastes (p <0.05).
Conclusion: In our study, it has been observed that some toothpastes produced with alternative active substances may have antimicrobial effects in in vitro conditions. Clinical studies are needed to evaluate the antibacterial efficacy of the active ingredients of the tooth pastes on the pH, saliva dilution in the mouth.
Keywords: tooth paste, fluoride, herbal toothpaste

Keywords

diş macunu, fluor, aloe vera

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