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INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD

Year 2021, Volume: 31 Issue: 1, 77 - 82, 15.01.2021
https://doi.org/10.17567/ataunidfd.814066

Abstract

Objectives: The purpose of this study was to explore the contribution of the genetics and the environment on the mandibular morphology of the Turkish twins.
Materials and Methods: This retrospective study conducted with the archival records of the twins who have applied between 2012 and 2018.Condylar height, ramus height, gonial angle, intercondylar distance and intergonial distance were measured on the panoramic radiographs with computer software. The correlations between the monozygotic (MZ) and dizygotic (DZ) twins, and heritability estimates were evaluated.
Results: Moderate to high heritability observed in condylar height, ramus height, intercondylar distance and left gonial angle. Low heritability observed in intergonial distance and right gonial angle. Similar intra-pair correlations were found within the MZ and DZ male and female twin pairs for the measured parameters. However, no significant correlations observed within the DZ opposite sex twins. No significant difference also observed within the MZ male and female twin pairs in terms of the measured parameters except the significant difference in right ramus height of male MZ twins.
Conclusion: Horizontal parameters were found to be more susceptible to environmental factors then vertical ones. Gender was found to be caused similar variability in the measured parameters. Beside the results of the present study, it should be considered that the heritability is a concept that related with population rather than an individual, it would not be correct to reach definitive conclusions regarding the prevention of the disruptions, and prognosis of the treatments. Thus, the results should be interpreted cautiously when they are transformed into the clinical applications.
Keywords: Heritability, twin study, mandible

GENETİK VE ÇEVRENİN MANDİBULAR MORFOLOJİYEKATKISININKLASİKİKİZ YÖNTEMİ İLE ARAŞTIRILMASI
ÖZET
Amaç: Bu çalışmanın amacı, genetik ve çevrenin, Türk ikizlerinin mandibular morfolojisine katkısını araştırmaktır.
Gereç ve Yöntem: Bu retrospektif çalışma 2012 ve 2018 yılları arasında başvuruda bulunan ikizlerin arşiv kayıtları ile yapılmıştır. Panoramik radyografilerde bilgisayar yazılımı ile kondiler yükseklik, ramus yüksekliği, gonial açı, interkondiler mesafe ve intergonial mesafe ölçülmüştür. Monozigotik (MZ) ve dizigotik (DZ) ikizler arasındaki ilişki ve kalıtım derecesi tahminleri değerlendirilmiştir.
Bulgular: Orta ila yüksek derecede kalıtım etkisi kondiler yükseklik, ramus yüksekliği, interkondiler mesafe ve sol gonial açı parametrelerinde gözlendi. İntergonial mesafe ve sağ gonial açıda ise düşük kalıtım etkisi tespit edildi. Ölçülen parametreler için MZ ve DZ erkek ve kadın ikiz çiftlerinde benzer korelasyonlar bulunmakla birlikte, DZ farklı cinsiyetteki ikizler arasında anlamlı bir ilişki gözlenmedi. MZ erkek ve kadın ikiz çiftlerinde, ölçülen parametreler açısından, erkek MZ ikizlerinin sağ ramus yüksekliğindeki anlamlı fark dışında, anlamlı bir fark gözlenmedi.
Sonuçlar: Yatay parametrelerin dikey olanlara göre çevresel faktörlere daha duyarlı olduğu bulunmuştur. Cinsiyetin ölçülen parametrelerde benzer değişkenliğe neden olduğu görülmüştür. Bu çalışmanın sonuçlarının yanı sıra, kalıtımın bir bireyden çok popülasyonla ilgili bir kavram olduğu, tedavilerin aksamalarının önlenmesi ve prognozu konusunda kesin sonuçlara varmanın doğru olmayacağı dikkate alınmalıdır. Bu nedenle sonuçlar klinik uygulamalara dönüştürülürken dikkatli yorumlanmalıdır.
Anahtar Sözcükler: Kalıtım derecesi, ikiz çalışması, mandibula

References

  • 1. Sidlauskas M, Salomskiene L, Andriuskeviciute I, et al. Heritability of mandibular cephalometric variables in twins with completed craniofacial growth. Eur J Orthod 2016;38:493-502.
  • 2. Ceylan, İ. Alt Çene Büyümesinin bir göstergesi olarak simfiz ve birinci servikal vertebranin morfolojisinin değerlendirilmesi. Atatürk Üniv Diş Hek Fak Derg 1995;5:23-30.
  • 3. Kim E, Sung J, Song YM, et al. Heritability of facial skeletal and dental characteristics of monozygotic and dizygotic twins using cephalometric analysis and falconer's method. J Craniofac Surg 2018;29: 274-9.
  • 4. Sidlauskas M, Salomskiene L, Andriuskeviciute I, Sidlauskiene M, Labanauskas Z, Sidlauskas A. Man- dibular morphology in monozygotic twins: a cepha- lometric study. Stomatologija 2014;16:137-43.
  • 5. Lundstrom A. Nature versus nurture in dento-facial variation. Eur J Orthod 1984;6(2):77-91.
  • 6. Peng J, Deng H, Cao C, Ishikawa M. Craniofacial morphology in Chinese female twins: a semi-longitudinal cephalometric study. Eur J Orthod 2005; 27:556-61.
  • 7. Dunn GF, Green LJ, Cunat JJ. Relationships between variation of mandibular morphology and variation of nasopharyngeal airway size in monozygotic twins. Angle Orthod 1973;43:129-35.
  • 8. Nakata M, Yu PL, Davis B, Nance WE. Genetic determinants of cranio-facial morphology: a twin study. Ann Hum Genet 1974;37:431-43.
  • 9. Carels C, Van Cauwenberghe N, Savoye I, et al. A quantitative genetic study of cephalometric variables in twins. Clin Orthod Res 2001;4:130-40.
  • 10. Amini F, Borzabadi-Farahani A. Heritability of dental and skeletal cephalometric variables in monozygous and dizygous Iranian twins. orthodontic waves 2009;68:72-9.
  • 11. Naini FB, Moss JP. Three-dimensional assessment of the relative contribution of genetics and environment to various facial parameters with the twin method. Am J Orthod Dentofacial Orthop 2004;126:655-65.
  • 12. Kaprio J, Sarna S, Koskenvuo M, Rantasalo I. The Finnish Twin Registry: formation and compilation, questionnaire study, zygosity determination procedures, and research program. Prog Clin Biol Res 1978;24:179-84.
  • 13. Manfredi C, Martina R, Grossi GB, Giuliani M. Heritability of 39 orthodontic cephalometric parameters on MZ, DZ twins and MN-paired singletons. Am J Orthod Dentofacial Orthop 1997; 111: 44-51.
  • 14. Lundstrom A, McWilliam JS. A comparison of vertical and horizontal cephalometric variables with regard to heritability. Eur J Orthod 1987;9:104-8.
  • 15. Dudas M, Sassouni V. The hereditary components of mandibular growth, a longitudinal twin study. Angle Orthod 1973;43:314-22.
  • 16. Back K, Ahlqwist M, Hakeberg M, Dahlstrom L. Occurrence of signs of osteoarthritis/arthrosis in the temporomandibular joint on panoramic radiographs in Swedish women. Community Dent Oral Epidemiol 2017;45:478-84.
  • 17. Godavarthi AS, Sajjan MC, Raju AV, Rajeshkumar P, Premalatha A, Chava N. Correlation of condylar guidance determined by panoramic radiographs to one determined by conventional methods. J Int Oral Health 2015;7:123-8.
  • 18. Van Elslande DC, Russett SJ, Major PW, Flores-Mir C. Mandibular asymmetry diagnosis with panoramic imaging. Am J Orthod Dentofacial Orthop 2008;134:183-92.
  • 19. Larheim TA, Svanaes DB. Reproducibility of rotational panoramic radiography: mandibular linear dimensions and angles. Am J Orthod Dentofacial Orthop 1986;90:45-51.
  • 20. Sadat-Khonsari R, Fenske C, Behfar L, Bauss O. Panoramic radiography: effects of head alignment on the vertical dimension of the mandibular ramus and condyle region. Eur J Orthod 2012;34:164-9.
  • 21. Harris EF, Johnson MG. Heritability of craniometric and occlusal variables: a longitudinal sib analysis. Am J Orthod Dentofacial Orthop 1991;99:258-68.

INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD

Year 2021, Volume: 31 Issue: 1, 77 - 82, 15.01.2021
https://doi.org/10.17567/ataunidfd.814066

Abstract

Aim: The purpose of this study was to explore the contribution of the genetics and the environment on the mandibular morphology of the Turkish twins.
Materials and Methods: This retrospective study conducted with the archival records of the twins who have applied between 2012 and 2018.Condylar height, ramus height, gonial angle, intercondylar distance and intergonial distance were measured on the panoramic radiographs with computer software. The correlations between the monozygotic (MZ) and dizygotic (DZ) twins, and heritability estimates were evaluated.
Results: Moderate to high heritability observed in condylar height, ramus height, intercondylar distance and left gonial angle. Low heritability observed in intergonial distance and right gonial angle. Similar intra-pair correlations were found within the MZ and DZ male and female twin pairs for the measured parameters. However, no significant correlations observed within the DZ opposite sex twins. No significant difference also observed within the MZ male and female twin pairs in terms of the measured parameters except the significant difference in right ramus height of male MZ twins.
Conclusion: Horizontal parameters were found to be more susceptible to environmental factors then vertical ones. Gender was found to be caused similar variability in the measured parameters. Beside the results of the present study, it should be considered that the heritability is a concept that related with population rather than an individual, it would not be correct to reach definitive conclusions regarding the prevention of the disruptions, and prognosis of the treatments. Thus, the results should be interpreted cautiously when they are transformed into the clinical applications.
Keywords: Heritability, twin study, mandible

GENETİK VE ÇEVRENİN MANDİBULAR MORFOLOJİYEKATKISININKLASİKİKİZ YÖNTEMİ İLE ARAŞTIRILMASI
ÖZET
Amaç: Bu çalışmanın amacı, genetik ve çevrenin, Türk ikizlerinin mandibular morfolojisine katkısını araştırmaktır.
Gereç ve Yöntem: Bu retrospektif çalışma 2012 ve 2018 yılları arasında başvuruda bulunan ikizlerin arşiv kayıtları ile yapılmıştır. Panoramik radyografilerde bilgisayar yazılımı ile kondiler yükseklik, ramus yüksekliği, gonial açı, interkondiler mesafe ve intergonial mesafe ölçülmüştür. Monozigotik (MZ) ve dizigotik (DZ) ikizler arasındaki ilişki ve kalıtım derecesi tahminleri değerlendirilmiştir.
Bulgular: Orta ila yüksek derecede kalıtım etkisi kondiler yükseklik, ramus yüksekliği, interkondiler mesafe ve sol gonial açı parametrelerinde gözlendi. İntergonial mesafe ve sağ gonial açıda ise düşük kalıtım etkisi tespit edildi. Ölçülen parametreler için MZ ve DZ erkek ve kadın ikiz çiftlerinde benzer korelasyonlar bulunmakla birlikte, DZ farklı cinsiyetteki ikizler arasında anlamlı bir ilişki gözlenmedi. MZ erkek ve kadın ikiz çiftlerinde, ölçülen parametreler açısından, erkek MZ ikizlerinin sağ ramus yüksekliğindeki anlamlı fark dışında, anlamlı bir fark gözlenmedi.
Sonuçlar: Yatay parametrelerin dikey olanlara göre çevresel faktörlere daha duyarlı olduğu bulunmuştur. Cinsiyetin ölçülen parametrelerde benzer değişkenliğe neden olduğu görülmüştür. Bu çalışmanın sonuçlarının yanı sıra, kalıtımın bir bireyden çok popülasyonla ilgili bir kavram olduğu, tedavilerin aksamalarının önlenmesi ve prognozu konusunda kesin sonuçlara varmanın doğru olmayacağı dikkate alınmalıdır. Bu nedenle sonuçlar klinik uygulamalara dönüştürülürken dikkatli yorumlanmalıdır.
Anahtar Sözcükler: Kalıtım derecesi, ikiz çalışması, mandibula

References

  • 1. Sidlauskas M, Salomskiene L, Andriuskeviciute I, et al. Heritability of mandibular cephalometric variables in twins with completed craniofacial growth. Eur J Orthod 2016;38:493-502.
  • 2. Ceylan, İ. Alt Çene Büyümesinin bir göstergesi olarak simfiz ve birinci servikal vertebranin morfolojisinin değerlendirilmesi. Atatürk Üniv Diş Hek Fak Derg 1995;5:23-30.
  • 3. Kim E, Sung J, Song YM, et al. Heritability of facial skeletal and dental characteristics of monozygotic and dizygotic twins using cephalometric analysis and falconer's method. J Craniofac Surg 2018;29: 274-9.
  • 4. Sidlauskas M, Salomskiene L, Andriuskeviciute I, Sidlauskiene M, Labanauskas Z, Sidlauskas A. Man- dibular morphology in monozygotic twins: a cepha- lometric study. Stomatologija 2014;16:137-43.
  • 5. Lundstrom A. Nature versus nurture in dento-facial variation. Eur J Orthod 1984;6(2):77-91.
  • 6. Peng J, Deng H, Cao C, Ishikawa M. Craniofacial morphology in Chinese female twins: a semi-longitudinal cephalometric study. Eur J Orthod 2005; 27:556-61.
  • 7. Dunn GF, Green LJ, Cunat JJ. Relationships between variation of mandibular morphology and variation of nasopharyngeal airway size in monozygotic twins. Angle Orthod 1973;43:129-35.
  • 8. Nakata M, Yu PL, Davis B, Nance WE. Genetic determinants of cranio-facial morphology: a twin study. Ann Hum Genet 1974;37:431-43.
  • 9. Carels C, Van Cauwenberghe N, Savoye I, et al. A quantitative genetic study of cephalometric variables in twins. Clin Orthod Res 2001;4:130-40.
  • 10. Amini F, Borzabadi-Farahani A. Heritability of dental and skeletal cephalometric variables in monozygous and dizygous Iranian twins. orthodontic waves 2009;68:72-9.
  • 11. Naini FB, Moss JP. Three-dimensional assessment of the relative contribution of genetics and environment to various facial parameters with the twin method. Am J Orthod Dentofacial Orthop 2004;126:655-65.
  • 12. Kaprio J, Sarna S, Koskenvuo M, Rantasalo I. The Finnish Twin Registry: formation and compilation, questionnaire study, zygosity determination procedures, and research program. Prog Clin Biol Res 1978;24:179-84.
  • 13. Manfredi C, Martina R, Grossi GB, Giuliani M. Heritability of 39 orthodontic cephalometric parameters on MZ, DZ twins and MN-paired singletons. Am J Orthod Dentofacial Orthop 1997; 111: 44-51.
  • 14. Lundstrom A, McWilliam JS. A comparison of vertical and horizontal cephalometric variables with regard to heritability. Eur J Orthod 1987;9:104-8.
  • 15. Dudas M, Sassouni V. The hereditary components of mandibular growth, a longitudinal twin study. Angle Orthod 1973;43:314-22.
  • 16. Back K, Ahlqwist M, Hakeberg M, Dahlstrom L. Occurrence of signs of osteoarthritis/arthrosis in the temporomandibular joint on panoramic radiographs in Swedish women. Community Dent Oral Epidemiol 2017;45:478-84.
  • 17. Godavarthi AS, Sajjan MC, Raju AV, Rajeshkumar P, Premalatha A, Chava N. Correlation of condylar guidance determined by panoramic radiographs to one determined by conventional methods. J Int Oral Health 2015;7:123-8.
  • 18. Van Elslande DC, Russett SJ, Major PW, Flores-Mir C. Mandibular asymmetry diagnosis with panoramic imaging. Am J Orthod Dentofacial Orthop 2008;134:183-92.
  • 19. Larheim TA, Svanaes DB. Reproducibility of rotational panoramic radiography: mandibular linear dimensions and angles. Am J Orthod Dentofacial Orthop 1986;90:45-51.
  • 20. Sadat-Khonsari R, Fenske C, Behfar L, Bauss O. Panoramic radiography: effects of head alignment on the vertical dimension of the mandibular ramus and condyle region. Eur J Orthod 2012;34:164-9.
  • 21. Harris EF, Johnson MG. Heritability of craniometric and occlusal variables: a longitudinal sib analysis. Am J Orthod Dentofacial Orthop 1991;99:258-68.
There are 21 citations in total.

Details

Primary Language English
Subjects Dentistry
Journal Section Araştırma Makalesi
Authors

Damla Torul This is me 0000-0003-2323-606X

Mehmet Melih Ömezli This is me 0000-0002-6606-6593

Mustafa Ay 0000-0003-3589-1889

Publication Date January 15, 2021
Published in Issue Year 2021 Volume: 31 Issue: 1

Cite

APA Torul, D., Ömezli, M. M., & Ay, M. (2021). INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 31(1), 77-82. https://doi.org/10.17567/ataunidfd.814066
AMA Torul D, Ömezli MM, Ay M. INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD. Ata Diş Hek Fak Derg. January 2021;31(1):77-82. doi:10.17567/ataunidfd.814066
Chicago Torul, Damla, Mehmet Melih Ömezli, and Mustafa Ay. “INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 31, no. 1 (January 2021): 77-82. https://doi.org/10.17567/ataunidfd.814066.
EndNote Torul D, Ömezli MM, Ay M (January 1, 2021) INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 31 1 77–82.
IEEE D. Torul, M. M. Ömezli, and M. Ay, “INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD”, Ata Diş Hek Fak Derg, vol. 31, no. 1, pp. 77–82, 2021, doi: 10.17567/ataunidfd.814066.
ISNAD Torul, Damla et al. “INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 31/1 (January 2021), 77-82. https://doi.org/10.17567/ataunidfd.814066.
JAMA Torul D, Ömezli MM, Ay M. INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD. Ata Diş Hek Fak Derg. 2021;31:77–82.
MLA Torul, Damla et al. “INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, vol. 31, no. 1, 2021, pp. 77-82, doi:10.17567/ataunidfd.814066.
Vancouver Torul D, Ömezli MM, Ay M. INVESTIGATION OF THE RELATIVE CONTRIBUTION OF GENETICS AND ENVIRONMENT ON MANDIBULAR MORPHOLOGY WITH THE CLASSICAL TWIN METHOD. Ata Diş Hek Fak Derg. 2021;31(1):77-82.

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