Veteriner Hekimlikte Papillomaviruslar ve Önemi

Year 2020, Volume: 15 Issue: 1, 91 - 99, 30.04.2020

Selvi Deniz Dörttaş , Seval Bilge Dağalp

https://doi.org/10.17094/ataunivbd.651002

Cited By: 2

Abstract

Papillomaviridae, insanlar dahil tüm omurgalıları enfekte edebilen, enfeksiyöz ajanlara bağlı olan kanser vakalarının % 27-30'undan sorumlu olduğu bilinen en geniş virus ailesidir. Son yıllarda, evcil ve vahşi hayvanlarda çok çeşitli lezyonlara neden olan papillomaviruslar, günümüzde giderek artan sayılarda tespit edilmektedir. Köpeklerde, kedilerde ve sığırlarda oluşan papillomlar veterinerlik alanında önemli bir problemi temsil etmektedir. Papillomaviruslar son yıllarda, büyük çoğunluğu insanlarda ve özellikle sığır, kedi, köpek ve at gibi diğer memeli hayvanlar olmak üzere kuşlar, kaplumbağalar, balıklar gibi memeli olmayan hayvanlarda ve vahşi hayvanlarda artan sayılarda tespit edilmektedir. Özellikle sığır, köpek, at, kemirgen ve insan papillomavirusları hastalıkların tanı, tedavi ve aşı değerlendirmesi için moleküler biyoloji ve hücre biyolojisi üzerine bir model olarak kullanılmakta ve araştırılmaktadır. Yapılan bu araştırmalarla papillomavirus evrimini, biyolojisini, türler arası etkileşimlerini anlama bakımından önemli gelişmeler kaydedilmiştir. Ayrıca çok çeşitli lezyonlara neden olan papillomaviruslar hayvan sağlığı üzerinde büyük etkiler yapabilmekte ve özellikle çiftlik hayvanlarında görülen papillomavirus kaynaklı hastalıklar önemli ölçüde ekonomik kayıplara neden olmaktadır. Bu derlemede, hayvan papillomavirusları hakkındaki son gelişmeleri genel kapsamlarıyla bir araya getirmek ve hızla gelişen bu alanla ilgili bir güncelleme yapmak hedeflenmiştir.

Keywords

papillomaviruslar, at, sığır, kedi, köpek

Papillomaviruses and Their Importance in Veterinary Medicine

Abstract

Papillomaviridae is the largest family of viruses known to be responsible for 27-30% of cancer cases due to infectious agents that can infect all vertebrates, including humans. In recent years, papillomaviruses, which cause a wide variety of lesions in domestic and wild animals, are now increasingly identified and papillomas in dogs, cats and cattle represent an important problem in veterinary medicine. In recent years, papillomaviruses have been detected in increasing numbers in humans and in non-mammals such as birds, turtles, fish, and other wild animals, particularly other mammals such as cattle, cats, dogs and horses. In particular, cattle, dogs, horses, rodents and human papillomaviruses are used as a model on molecular biology and cell biology for the diagnosis, treatment and vaccine evaluation of diseases. With these studies, important developments have been made in terms of understanding the evolution, biology and inter-species interactions of papillomavirus. In addition, papillomaviruses, which cause a wide variety of lesions, can have great effects on animal health, and especially papillomavirus-related diseases in farm animals cause significant economic losses. This study aims to bring together the latest developments in animal papillomaviruses with their general scope and make an update on this rapidly developing field.

Keywords

Bovine, Cat, Dog, Horse, Papillomaviruses

References

• 1. Araldi RP., Assaf SMR., Carvalho RF., Carvalho MACR., Souza JM., Magnelli RF., Modolo DG., Roperto FP., Stocco RC., Beçak W., 2017. Papillomaviruses: a systematic review. Genet Mol Biol, 40, 1-21. 2. Knipe DN., Howley PM., 2013. Fields’ Virology Sixth Edition Lippincott Williams & Wilkins, Philadelphia, PA, USA., 3. Van Doorslaer KV., Chen Z., Bernard HU., Chan PK., DeSalle R., Dillner J., Forslund O., Haga T., McBridge AA., Villa LL., Burk RD., 2018. ICTV virus taxonomy profile: Papil-lomaviridae. J GenVirol, 99, 989-990. 4. De Villiers EM., Fauquet C., Broker TR., Bernard HU., Zur Hausen H., 2004. Classifica-tion of papillomaviruses. Virology, 324, 17-27. 5. ICTV (International Committe Taxonomy of Viruses)., 2011. Reports-Papillomaviridae. 6. Bravo IG., Felez-Sanchez M., 2015. Papillomaviruses viral evolution, cancer and evolutionary medicine. Evol Med Public Heal, 28, 32-51. 7. Dubovi E. J., Maclachlan J.N., (2017). Papillomaviridae and Polyomaviridae. Fenner’s Veterinary Virology, Academic press, Chapter 11. 229-243. 8. Zheng ZM., Baker CC., 2006. Papillomavirus genome structure, expression, and post-transcriptional regulation. Front Biosci, 11, 2286-302. 9. Lunardi M., Alcindo A., Alejandro R., Fernandes A., 2013. Bovine Papillomaviruses-Taxonomy and Genetic Features. In: Current Issues in Molecular Virology-Viral Genetics and Biotechnological Applications. InTech 10. Van Doorslaer K., Ruoppolo V., Schmidt A., Lescroel A., Jongsomjit D., Elrod M., Krab-erger S., Stainton D., Dugger KM., Ballard G., Ainley DG., Varsani A., 2017. Unique genome organization of non-mammalian papillomaviruses provides insights into the evolution of viral early proteins. Virus Evol, 3, 1-12. 11. Daudt C., da Silva FR., Cibulski SP., Streck AF., Laurie RE., Munday JS., 2019. Bovine papillomavirus 24: a novel member of the genus Xipapillomavirus detected in the Amazon region. Arch Virol, 164, 637-641. 12. Tan MT., Yıldırım Y., Sozmen M., Bilge Dağalp S., Yilmaz V., Kirmizigül AH., Gokce E., 2012. A histopathological, ımmunohistochemical and molecular study of cutaneous bovine papillomatosis. Kafkas Univ Vet Fak Derg, 18, 739-744. 13. Timurkan MO., Alcigir ME., 2017. Phylogenetic analysis of a partial L1 gene from bovine papillomavirus type 1 isolated from naturally occurring papilloma cases in the northwestern region of Turkey. Onderstepoort J Vet, 84, 1-6. 14. Oğuzoğlu TÇ., Koç BT., Akkutay-Yoldar Z., Salar S., Baştan A., 2019. Detection and whole genomic characterization of Bovine Papillomavirus type 1 associated with severe mammary cutaneous warts in Turkey. Vet Mexico, 6(3) 1-11. 15. Ataseven VS., Kanat Ö., Ergün Y., 2016. Molecular identification of bovine papillomaviruses in dairy and beef cattle: first description of Xi- and Epsilonpapillomavirus in Turkey. Turkısh J Vet Anim Sci, 40, 757-763. 16. Bilge Dagalp S., Dogan F., Farzanı TA., Salar S., Bastan A., 2017. The genetic diversity of bovine papillomaviruses (BPV) from different papillomatosis cases in dairy cows in Turkey. Arch Virol, 162, 1507-1518. 17. Bocaneti F., Altamura G., Corteggio A., Velescu E., Roperto F., Borzacchiello G., 2016. Bovine papillomavirus: new insights into an old disease. Transbound Emerg Dis, 63, 14-23. 18. Roperto S., Munday JS., Corrado F., Goria M., Roperto F., 2016. Detection of bovine papillomavirus type 14 DNA sequences in urinary bladder tumors in cattle. Vet Microbiol, 190, 1-4. 19. Gil da Costa RM., Peleteiro MC., Pires MA., Dimaio D., 2017. An Update on Canine, Feline and Bovine Papillomaviruses. Transbound Emerg Dis, 64, 1371-1379. 20. Modolo DG., Araldi RP., Mazzuchelli-de-Souza J., Pereira A., Pimenta DC., Zanphorlin LM., Beçak W., Menossi M., Stocco RC., Franco R., Carvalho RF., 2017. Integrated analysis of recombinant BPV-1 L1 protein for the production of a bovine papillomavi-rus VLP vaccine. Vaccine, 35, 1590-1593. 21. Campo MS., 2002. Animal models of papillomavirus pathogenesis. Virus Res, 89, 249-261. 22. Munday JS., 2014. Bovine and Human Papillomaviruses. Vet Pathol, 51, 1063-1075. 23. Jeremiah OT., Fagbohun OA., Babalo OJ., 2016. Molecular detection of bovine papilloma viruses associated with cutaneous warts ın some breeds ofnigerian cattle. Int J Biotechnol Biochem, 12, 123-130. 24. Forslund O., Antonsson A., Nordin P., Stenquist BO., Hansson BG., 1999. A broad range of human papillomavirus types detected with a general PCR method suitable for analysis of cutaneous tumours and normal skin. J Gen Virol, 80, 2437-2443. 25. Ogawa T., Tomita Y., Okada M., Shinozaki K., Kubonoya H., Kaiho I., Shirasawa H., 2004. Broad-spectrum detection of papillomaviruses in bovine teat papillomas and healthy teat skin. J GenVirol, 85, 2191-2197. 26. Christensen ND., Budgeon LR., Cladel NM., Hu J., 2017. Recent advances in preclinical model systems for papillomaviruses. Virus Res, 231, 108-118. 27. Gil da Costa RM., Medeiros R., 2014. Bovine papillomavirus: Opening new trends for comparative pathology. Arch Virol, 159, 191-198. 28. Linder KE., Bizikova P., Luff J., Zhou D., Yuan H., Breuhaus B., Nelson E., Mackay R., 2018. Generalized papillomatosis in three horses associated with a novel equine papil-lomavirus (Ec PV 8). Vet Dermatol, 29, 72-e30. 29. Torres SMF., Koch SN., 2013. Papillomavirus-associated diseases. Vet Clin North Am Equine Pract, 29, 643-655. 30. Kanat Ö., Ataseven VS., Babaeski S., Derelli F., Kumaş C., Doğan F., Bilge Dağalp S., 2019. Equine and bovine papillomaviruses from Turkish brood horses: a molecular identification and immunohistochemical study. Vet Arhiv, 89, 601-611. 31. Borzacchiello G., 2007. Bovine papillomavirus infections in animals. Commun Curr Res Educ Top Trends Appl Microbiol,2, 673-679. 32. Altamura G., Jebara G., Cardeti G., Borzacchiello G., 2018. Felis catus papillomavirus type-2 but not type-1 is detectable and transcriptionally active in the blood of healthy cats. Transbound Emerg Dis, 65, 497-503. 33. Dunowska M., Munday JS., Laurie RE., Hills SFK., 2014. Genomic characterisation of Felis catus papillomavirus 4, a novel papillomavirus detected in the oral cavity of a domestic cat. Virus Genes, 48, 111-119. 34. Munday JS., 2014. Papillomaviruses in felids. Vet J, 199, 340-347. 35. Munday JS., Thomson NA., Luff JA., 2017. Papillomaviruses in dogs and cats. Vet J, 225, 23-31. 36. Munday JS., Dittmer KE., Thomson NA., Hills SF., Laurie RE., 2017. Genomic characterisation of Felis catus papillomavirus type 5 with proposed classification within a new papillomavirus genus. Vet Microbiol, 207, 50-55. 37. Lange CE., Favrot C., 2011. Canine Papillomaviruses. Vet Clin North Am Small Anim Pract, 41, 1183-1195. 38. Günay C., Sağlıyan A., Özkaraca M., 2011. Bir köpekte oral papillomatozis ve cyclophosphamide ile sağaltımı. FÜ Sağ Bil Vet Derg, 25, 135-139. 39. Lange CE., Tobler K., Schraner EM., Vetsch E., Fischer NM., Ackermann M., Favrot C., 2013. Complete canine papillomavirus life cycle in pigmented lesions. Vet Microbiol, 162, 388-395. 40. Munday JS., Tucker RS., Kiupel M., Harvey CJ., 2015. Multiple oral carcinomas associated with a novel papillomavirus in a dog. J Vet Diagn Invest, 27, 221-225. 41. Dogan F., Dorttas SD., Dagalp SB., Ataseven VS., Alkan F., 2018. A teat papillomatosis case in a Damascus goat (Shami goat) in Hatay province, Turkey: a new putative papil-lomavirus? Arch Virol, 163, 1635-1642.