Turunçgil Ekstraktı Anti-giardial Terapötik Destek Sağlayabilir mi?

Year 2021, Volume 16, Issue 2, 149 - 154, 31.10.2021

Deniz ALIÇ URAL Songül ERDOĞAN Canberk BALIKÇI Adnan AYAN Hasan ERDOĞAN Kerem URAL

https://doi.org/10.17094/ataunivbd.798450

Abstract

Bu araştırmada turunçgil ekstraktının, giardiasisli oğlaklardaki sağaltım etkinliğinin araştırılması amaçlandı. Bu kapsamda araştırmaya 12-68 günlük yaş aralığında Giardia duodenalis ile enfekte olduğu belirlenen 18 oğlak dahil edildi. Oğlaklar hiçbir ilaç uygulamasının yapılmadığı, kontrol grubu (n=8) ve 10 ml/hayvan başına dozda 7 gün boyunca turunçgil ekstraktının uygulandığı grup (n=10) olacak şekilde rastgele 2 gruba ayrıldı. Turunçgil ekstraktının anti-giardial terapötik etkisi, 0. ve 10. günlerdeki dışkının mikroskobik incelemesindeki ookist saçılımı ile belirlendi. Onuncu gündeki turunçgil ekstraktının terapötik etkinliğinin kontrol grubuna göre %99.9 olduğu ortaya çıkarıldı. Sonuç olarak ookist saçılımındaki kuvvetli azalma, turunçgil ekstraktının anti-giardiyal etkinliğini desteklemekte ve giardiazis sağaltımında alternatif olabileceğini göstermektedir.

Keywords

giardia, ishal, küçük ruminant, sağaltım, turunçgil ekstraktı

May Citrus Extract Provide Anti-Giardial Therapeutic Efficacy?

Abstract

In this study, it was aimed to investigate the therapeutic efficacy of the bitter orange extract in goat kids with giardiasis. A total of sixteen goat kids detected to be infected with Giardia duodenalis at the age of 12 to 68 days were enrolled in the study. Goat kids were randomly assigned into two groups, whereas goat kids in the control group (n= 8) without receiving any drug and group (n=10) received oral bitter orange extract at a dosage of 10 ml/goat kids for seven days. Anti-giardial therapeutic efficacy of bitter orange extract was determined by oocyst shedding interpreted with a microscopical examination of fecal samples on days 0 and 10. It was revealed that the therapeutic efficacy of orange bitter extract as compared with control was 99.9% on day 10. In conclusion, this significant decrease of oocyst shedding supports the anti-giardial activity of bitter orange extract and shows that it might be an alternative in the treatment of giardiasis.

Keywords

citrus extract, diarrhea, giardiasis, small ruminant, treatment

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